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001-es BibID:	BIBFORM104498
035-os BibID:	(WoS)000819615300001 (Scopus)85132024237 (cikkazonosító)1559
Első szerző:	Czeglédi Levente (agrármérnök)
Cím:	Relationship between Plasma Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Level and Proteome Profile of Cows / Czegledi Levente, Csosz Eva, Gulyas Gabriella
Dátum:	2022
ISSN:	2076-2615
Megjegyzések:	Pituitary adenylate cyclase-activating polypeptide (PACAP) is a pleiotropic and multifunc- tional neuropeptide; it takes part in the regulation of various physiological processes, such as feeding, reproduction, catecholamine synthesis, thermoregulation, motor activity, brain development and neuronal survival. Since PACAP plays important regulatory roles, we hypothesized that the level of PACAP in blood is associated with expression of other proteins, which are involved in different metabolic pathways. The objective of the present study was to compare plasma protein profiles of cows with high and low plasma PACAP levels. Differential proteome analyses were performed by two-dimensional gel electrophoresis (2D-PAGE) followed by tryptic digestion and protein identi- fication by liquid chromatography?mass spectrometry (LC-MS). A total of 210 protein spots were detected, and 16 protein spots showed statistically significant differences (p < 0.05) in the expression levels between groups. Ten spots showed a higher intensity in the high-PACAP-concentration group, while six spots were more abundant in the low-PACAP-concentration group. The functions of the differentially expressed proteins indicate that the PACAP level of plasma is related to the lipid metabolism and immune status of cattle.
Tárgyszavak:	Agrártudományok Állattenyésztési tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk PACAP cattle protein expression 2D-PAGE
Megjelenés:	Animals. - 12 : 12 (2022), p. 1-12. -
További szerzők:	Csősz Éva (1977-) (biokémikus, molekuláris biológus) Gulyás Gabriella (1985-) (agrár)
Pályázati támogatás:	EFOP-3.6.1-16-2016-00022 EFOP EFOP-3.6.3-VEKOP-16-2017-00008 EFOP
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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