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001-es BibID:	BIBFORM119806
035-os BibID:	(Scopus)85188419101 (WoS)001190325200001
Első szerző:	Ndunguru, Sawadi Fransisco (1980-)
Cím:	Embryonic methionine triggers post-natal developmental programming in Japanese quail / Ndunguru, Sawadi F.; Reda, Gebrehaweria K.; Csernus, Brigitta; Knop, Renáta; Gulyás, Gabriella; Szabó, Csaba; Czeglédi, Levente; Lendvai, Ádám Z.
Dátum:	2024
ISSN:	0174-1578
Megjegyzések:	Embryonic development is one of the most sensitive and critical stages when maternal effects may influence the offspring's phenotype. In birds and other oviparous species, embryonic development is confined to the eggs, therefore females must deposit resources into the eggs to prepare the offspring for the prevailing post-natal conditions. However, the mechanisms of such phenotypic adjustments remain poorly understood. We simulated a maternal nutritional transfer by injecting 1 mg of l-methionine solution into Japanese quail eggs before the onset of incubation. The increase in early methionine concentration in eggs activated the insulin/insulin-like signalling and mechanistic target of rapamycin (IIS/mTOR) signalling pathways and affected post-natal developmental trajectories. Chicks from methionine-supplemented eggs had higher expression of liver IGF1 and mTOR genes at hatching but were similar in size, and the phenotypic effects of increased growth became apparent only a week later and remained up to three weeks. Circulating levels of insulin-like growth factor-1 (IGF-1) and expression of ribosomal protein serine 6 kinase 1 (RPS6K1), the mTOR downstream effector, were elevated only three weeks after hatching. These results show that specific nutritional cues may have phenotypic programming effects by sequentially activating specific nutrient-sensing pathways and achieving transgenerational phenotypic plasticity.
Tárgyszavak:	Agrártudományok Állattenyésztési tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk L-methionine IGF1 mTOR Growth Amino acid
Megjelenés:	Journal Of Comparative Physiology B-Biochemical Systemic And Environmental Physiology. - Epub (2024), p. 1-11. -
További szerzők:	Reda, Gebrehaweria Kidane (Phd hallgató) Csernus Brigitta (1991-) (élelmiszerbiztonsági és -minőségi mérnök) Knop Renáta (1983-) (állatorvos) Gulyás Gabriella (1985-) (agrár) Szabó Csaba (1968-) (agrármérnök) Czeglédi Levente (1977-) (agrármérnök) Lendvai Ádám Zoltán (1977-) (biológus)
Pályázati támogatás:	K139021 OTKA
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM120372
035-os BibID:	(Scopus)85188475659 (WoS)001222859800002
Első szerző:	Reda, Gebrehaweria Kidane (Phd hallgató)
Cím:	Dietary restriction and life-history trade-offs: insights into mTOR pathway regulation and reproductive investment in Japanese quails / Gebrehaweria K. Reda, Sawadi F Ndunguru, Brigitta Csernus, Gabriella Gulyás, Renáta Knop,Csaba Szabó, Levente Czeglédi, Ádám Z. Lendvai
Dátum:	2024
ISSN:	0022-0949
Megjegyzések:	Resources are needed for growth, reproduction and survival, and organisms must trade-off limited resources among competing processes. Nutritional availability in organisms is sensed and monitored by nutrient-sensing pathways that can trigger physiological changes or alter gene expression. Previous studies have proposed that one such signalling pathway, the mechanistic target of rapamycin (mTOR), underpins a form of adaptive plasticity when individuals encounter constraints in their energy budget. Despite the fundamental importance of this process in evolutionary biology, how nutritional limitation is regulated through the expression of genes governing this pathway and its consequential effects on fitness remains understudied, particularly in birds. We used dietary restriction to simulate resource depletion and examined its effects on body mass, reproduction and gene expression in Japanese quails (Coturnix japonica). Quails were subjected to feeding 20%, 30%, 40% restriction levels or ad libitum for two weeks. All restricted groups exhibited reduced body mass, whereas reductions in the number and mass of eggs were observed only under more severe restrictions. Additionally, dietary restriction led to decreased expression of mTOR and insulin-like growth factor 1 (IGF1), whereas the ribosomal protein S6 kinase 1 (RPS6K1) and autophagy-related genes (ATG9A and ATG5) were upregulated. The pattern in which mTOR respond to restriction was similar to what has been seen in body mass. Regardless of the treatment, proportionally higher reproductive investment was associated with individual variation in mTOR expression. These findings reveal the connection between dietary intake and the expression of mTOR and related genes in this pathway.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Journal Of Experimental Biology. - 227 : 8 (2024), p. 1-11. -
További szerzők:	Ndunguru, Sawadi Fransisco (1980-) Csernus Brigitta (1991-) (élelmiszerbiztonsági és -minőségi mérnök) Gulyás Gabriella (1985-) (agrár) Knop Renáta (1983-) (állatorvos) Szabó Csaba Czeglédi Levente (1977-) (agrármérnök) Lendvai Ádám Zoltán (1977-) (biológus)
Pályázati támogatás:	K139021 OTKA
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: