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001-es BibID:	BIBFORM123748
035-os BibID:	(scopus)85196072419 (wos)001248382500001
Első szerző:	Gálffy Gabriella
Cím:	Decreasing incidence and mortality of lung cancer in Hungary between 2011 and 2021 revealed by robust estimates reconciling multiple data sources / Gálffy Gabriella, Szabó Géza Tamás, Tamási Lilla, Müller Veronika, Moldvay Judit, Sárosi Veronika, Kerpel-Fronius Anna, Kardos Tamás, Csada Edit, Pápai-Székely Zsolt, Szász Zoltán, Király Zsolt, Hódi Gábor, Kovács Zsuzsanna, Balogh Éva, Kovács Krisztina Andrea, Darida Miklós, Buga Viktória, Rokszin György, Abonyi-Tóth Zsolt, Kiss Zoltán, Vokó Zoltán, Bogos Krisztina
Dátum:	2024
ISSN:	1219-4956 1532-2807
Megjegyzések:	Objective: Hungary has repeatedly been shown to have the highest cancer-related mortality and incidence in Europe. Despite lung cancer being the most abundant malignant diagnosis in Hungary, numerous concerns have been raised recently regarding the bias inherent to reported incidence estimates. Re-analysis of reimbursement claims has been suggested previously by our group as an alternative approach, offering revised figures of lung cancer incidence between 2011 and 2016. Leveraging on this methodology, we aimed at updating Hungarian lung cancer incidence estimates with an additional 5 years (2017?2021), including years affected by the COVID-19 pandemic. Additionally, we also attempted to improve the robustness of estimates by taking additional characteristics of the patient pathway into account. Methods: Lung cancer patients between 2011 and 2021 were identified based on reimbursement-associated ICD-10 codes, histology codes and time patterns. Multiple query architectures were tested for sensitivity and compared to official estimates of the Hungarian National Cancer Registry (HNCR). Epidemiological trends were estimated by Poisson-regression, corrected for age and sex. Results: A total of 89,948 lung cancer patients diagnosed in Hungary between 2011 and 2021 have been identified by our study. In 2019 alone, 7,887 patients were diagnosed according to our optimized query. ESP2013 standardized rate was estimated between 92.5/100,000 (2011) and 78.4/100,000 (2019). In 2019, standardized incidence was 106.8/100,000 for men and 59.7/100,000 for women. Up until the COVID-19 pandemic, lung cancer incidence was decreasing by 3.18% (2.1%?4.3%) yearly in men, while there was no significant decrease in women. Young age groups (40?49 and 50?59) featured the largest improvement, but women aged 60?79 are at an increasing risk for developing lung cancer. The COVID-19 pandemic resulted in a statistically significant decrease in lung cancer incidence, especially in the 50?59 age group (both sexes). Conclusion: Our results show that using an optimized approach, re-analysis of reimbursement claims yields robust estimates of lung cancer incidence. According to this approach, the incidence rate of male lung cancer is declining in Hungary, in concordance with the trend observed for lung cancer mortality. Among women aged 60?79, the incidence of lung cancer has risen, requiring more attention in the near future. Copyright ? 2024 Gálffy, Szabó, Tamási, Müller, Moldvay, Sárosi, Kerpel-Fronius, Kardos, Csada, Pápai-Székely, Szász, Király, Hódi, Kovács, Balogh, Kovács, Darida, Buga, Rokszin, Abonyi-Tóth, Kiss, Vokó and Bogos.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk COVID-19 Hungary incidence lung cancer mortality
Megjelenés:	Pathology & Oncology Research. - 30 (2024), p. 1-11. -
További szerzők:	Szabó Géza Tamás Tamási Lilla Müller Veronika Moldvay Judit Sárosi Veronika Kerpel-Fronius Anna Kardos Tamás (1980-) (pulmonológus, klinikai onkológus) Csada Edit Pápai-Székely Zsolt Szász Zoltán Király Zsolt Hódi Gábor Kovács Zsuzsanna Balogh Éva Kovács Krisztina Andrea Darida Miklós Buga Viktória Rokszin György Abonyi-Tóth Zsolt Kiss Zoltán (Pécs) Vokó Zoltán (1968-) (epidemiológus) Bogos Krisztina
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001-es BibID:	BIBFORM122029
035-os BibID:	(scopus)85198755613
Első szerző:	Lieber Attila
Cím:	The role of immunotherapy in early stage and metastatic NSCLC / Attila Lieber, Attila Makai, Zsuzsanna Orosz, Tamás Kardos, Susil Joe Isaac, Ilona Tornyi, Nora Bittner
Dátum:	2024
Megjegyzések:	In the past decade we have seen new advances and by that remarkable progress in therapeutic possibilities of non-small cell lung cancer (NSCLC). Among cytostatic therapies with new approaches in molecularly targeted therapies, we see new development in a wide range of applications for immunotherapies. In this review we discuss the new potential modalities for the use of immune checkpoint inhibitors (ICIs) in frontline, including ? early stage (perioperative) and metastatic setting. The perioperative use of ICIs in both neoadjuvant and adjuvant setting may show benefit for patients. In early-stage NSCLC (from stage IIB and above) multimodal approach is recommended as gold standard for the treatment. After surgical resection platinum-based adjuvant chemotherapy was the standard of care for many years. Based on the benefit in disease free survival, the approval of adjuvant atezolizumab and adjuvant pembrolizumab were a significant breakthrough. In metastatic setting, the use of immune checkpoint inhibitor with chemotherapy, regardless of PD-L1 expression or ICI alone (PD-L1 expression equal or greater than 50%) improves overall survival and progression-free survival as well.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény hazai lapban folyóiratcikk NSCLC PD-(L)1 ICI perioperative metastatic
Megjelenés:	Pathology and Oncology Research. - 30 (2024), p. 1-17. -
További szerzők:	Makai Attila (1987-) (tüdőgyógyász szakorvos) Orosz Zsuzsanna (1974-) (Orvos) Kardos Tamás (1980-) (pulmonológus, klinikai onkológus) Susil, Joe Isaac Tornyi Ilona (1982-) (molekuláris biológus) Bittner Nóra (1963-) (orvos)
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