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001-es BibID:BIBFORM109702
035-os BibID:(cikkazonosító)2238 (Scopus)85151612301 (WoS)000956763900001
Első szerző:Árokszállási Tamás (neurológus)
Cím:Elevated Blood Alcohol Concentration Is Associated with Improved Clinical Outcomes of Intravenous Thrombolysis Treatment in Acute Ischemic Stroke Patients : A Retrospective Study / Árokszállási Tamás, Balogh Eszter, Orbán-Kálmándi Rita, Pásztor Máté, Árokszállási Anita, Nagy Edit Boglárka, Belán Ivett, May Zsolt, Csépány Tünde, Csiba László, Bagoly Zsuzsa, Oláh László
Dátum:2023
ISSN:2077-0383
Megjegyzések:Background: Intravenous thrombolysis (IVT) improves acute ischemic stroke (AIS) outcomes, but with limited success. In addition, ethanol potentiates the effect of r-tPA in ischemia models. Methods: The effect of acute alcohol consumption on IVT outcomes was investigated in a retrospective cohort study. AIS patients with detectable blood alcohol concentration (BAC) during IVT were included (alcohol group; n = 60). For each case, 3 control subjects who underwent IVT but denied alcohol consumption were matched in terms of age, sex, affected brain area, and stroke severity. Outcomes were determined using the NIHSS at 7 days and the modified Rankin scale (mRS) at 90 days. Results: Patients were younger and had a less severe stroke than in a standard stroke study. Favorable long-term outcomes (mRS 0?2) occurred significantly more frequently in the alcohol group compared to controls (90% vs. 63%, p < 0.001). However, the rates of hemorrhagic transformation were similar. Multiple logistic regression models identified elevated BAC as a significant protective factor against unfavorable short-term (OR: 0.091, 95% CI: 0.036?0.227, p < 0.001) and long-term outcomes (OR: 0.182, 95% CI: 0.062?0.535, p = 0.002). In patients with BAC > 0.2%, significantly lower NIHSS was observed at 3 and 7 days after IVT vs. in those with 0.01?0.2% ethanol levels. Conclusion: Elevated BAC is associated with improved outcomes in IVT-treated AIS without affecting safety.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
stroke
observational study
thrombolysis
ethanol
outcomes
Megjelenés:Journal of Clinical Medicine. - 12 : 6 (2023), p. 1-13. -
További szerzők:Balogh Eszter (1991-) (neurológus) Orbán-Kálmándi Rita Angéla (1993-) (klinikai laboratóriumi kutató) Pásztor Máté Árokszállási Anita (1982-) (orvos) Nagy Edit Boglárka Belán Ivett May Zsolt Csépány Tünde (1956-) (neurológus, pszichiáter) Csiba László (1952-) (neurológus, pszichiáter) Bagoly Zsuzsa (1978-) (orvos) Oláh László (1967-) (neurológus)
Pályázati támogatás:Nemzeti Agykutatási Program (NAP) 2017-1.2.1-NKP-2017-00002
Egyéb
ELKH-DE Cerebrovascularis Kutatócsoport
MTA
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2.

001-es BibID:BIBFORM076872
Első szerző:Árokszállási Tamás (neurológus)
Cím:Acute alcohol intoxication may cause delay in stroke treatment : case reports / ATamas Arokszallasi, Eszter Balogh, Laszlo Csiba, Istvan Fekete, Klara Fekete, Laszlo Olah
Dátum:2019
ISSN:1471-2377
Megjegyzések:Background:The signs and symptoms of acute alcohol intoxication resemble those of vertebrobasilar stroke. Dueto their shared symptoms including double vision, nystagmus, dysarthria, and ataxia, the differential diagnosis ofalcohol intoxication and vertebrobasilar stroke may pose a challenge. Moreover, if alcohol intoxication and strokeoccur simultaneously, the signs and symptoms of stroke may be attributed to the effects of alcohol, leading todelayed stroke diagnosis and failure to perform reperfusion therapy.Case presentations:Three cases of alcohol intoxication and stroke are presented. The first patient (female, 50 yearsold) had dysarthria, nystagmus and trunk ataxia on admission. Her blood alcohol level was 2.3?.The symptomsimproved after forced diuresis, but 5.5 h later progression was observed, and the patient developed diplopia anddysphagia in addition to her initial symptoms. Angiography showed occlusion of the basilar artery. Intraarterialthrombolysis was performed. The second patient (male, 62 years old) developed diplopia, dysarthria and trunkataxia after consuming 4-units of alcohol, and his symptoms were attributed to alcohol intoxication. Two hourslater, neurological examination revealed dysphagia and mild right-sided hemiparesis, which questioned the causalrelationship between the symptoms and alcohol consumption. Cerebral CT was negative, and intravenousthrombolysis was administered. The third patient (male, 55 years old) consumed 10 units of alcohol before fallingasleep. Three hours later, his relatives tried to wake him up. He was unresponsive, which was attributed to alcoholintoxication. When he woke up 8 h later, right-sided hemiparesis and aphasia were observed, and cerebral CTalready revealed irreversible ischemic changes.Conclusions:Our cases show that alcohol consumption may interfere with stroke diagnosis by mimicking the signsand symptoms of vertebrobasilar stroke. Moreover, attributing the symptoms of stroke to alcohol intoxication maydelay stroke diagnosis resulting in failure of reperfusion therapy. Based on our observations we conclude that strokeshould be considered in the case of worsening symptoms, dysphagia, hemiparesis and disproportionately severesigns that cannot be attributed to the amount of alcohol consumed. In the case of ambiguity, ambulance shouldbe called, and if stroke cannot be excluded, specific therapy should be administered.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
alcohol intoxication
stroke
thrombolytic therapy
diagnostic errors
Megjelenés:BMC Neurology. - 19 : 1 (2019), p. 1-5. -
További szerzők:Balogh Eszter (1991-) (neurológus) Csiba László (1952-) (neurológus, pszichiáter) Fekete István (1951-) (neurológus, pszichiáter) Fekete Klára (1978-) (neurológus) Oláh László (1967-) (neurológus)
Pályázati támogatás:NAP_13-1-2013-0001
Egyéb
2017-1.2.1-NKP-2017-00002
Egyéb
NFKH-K 120042
Egyéb
NFKH-K 109712
Egyéb
Internet cím:Szerző által megadott URL
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Intézményi repozitóriumban (DEA) tárolt változat
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3.

001-es BibID:BIBFORM093908
Első szerző:Balogh Eszter (neurológus)
Cím:Effects of acute alcohol consumption on neuronal activity and cerebral vasomotor response / Balogh Eszter, Árokszállási Tamás, Körtefái Katalin, Nagy Veronika Éva, Csiba László, Oláh László
Dátum:2021
ISSN:1590-1874
Megjegyzések:Introduction In the majority of European countries, driving after drinking small-moderate amount of alcohol is legal. Motivated by our previous studies on cerebral hemodynamics, we aimed to study whether a small-moderate blood alcohol content (BAC), at which driving is legal in some countries (0.8 g/L), influences the neuronal activity, neurovascular coupling, and cerebral vasoreactivity. Methods Analyses of pattern-reversal visual evoked potential (VEP) and transcranial Doppler (TCD) examinations were performed in thirty young healthy adults before and 30 min after alcohol consumption. Cerebral vasoreactivity was evaluated by breath holding test in both middle cerebral arteries. By using a visual cortex stimulation paradigm, visually evoked flow velocity response during reading was measured in both posterior cerebral arteries (PCA). Results The BAC was 0.82 g/L and 0.94 g/L 30 and 60 min after drinking alcohol, respectively. Latency of the VEP P100 wave increased after alcohol consumption. Resting absolute flow velocity values increased, whereas pulsatility indices in the PCA decreased after alcohol ingestion, indicating vasodilation of cerebral microvessels. Breath holding index and the visually evoked maximum relative flow velocity increase in the PCA and steepness of rise of the flow velocity curve were smaller after than before alcohol consumption. Conclusion BAC close to a legal value at which driving is allowed in some European countries inhibited the neuronal activity and resulted in dilation of cerebral arterioles. Cerebral vasodilation may explain the decrease of cerebral vasoreactivity and might contribute to the disturbance of visually evoked flow response after alcohol consumption.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Acute alcohol consumption
Cerebral vasoreactivity
Neurovascular coupling
Transcranial Doppler
Visual activation
Megjelenés:Neurological Sciences. - 43 (2021), p. 625-631. -
További szerzők:Árokszállási Tamás (1988-) (neurológus) Körtefái Katalin Nagy Veronika Csiba László (1952-) (neurológus, pszichiáter) Oláh László (1967-) (neurológus)
Pályázati támogatás:Nemzeti Agykutatási Program (NAP_13-1-2013-0001)
Egyéb
Nemzeti Agykutatási Program (2017-1.2.1-NKP-2017-00002)
Egyéb
GINOP-2.3.2-15-2016-00043
GINOP
MTA-DE Cerebrovascular and Neurodegenerative Research Group
MTA
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Intézményi repozitóriumban (DEA) tárolt változat
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4.

001-es BibID:BIBFORM078127
035-os BibID:(PMID)30729534
Első szerző:Balogh Eszter (neurológus)
Cím:Effect of reading with direct or indirect light on the visually evoked flow response in the posterior cerebral artery / Eszter Balogh, Tamás Árokszállási, László Csiba, László Oláh
Dátum:2019
ISSN:0091-2751
Megjegyzések:Purpose: Reading with direct light from computer monitors or tablets may cause visual fatigue and hamper reading comprehension. Our aim was to compare the blood flow response in the supplying artery of the visual cortex when reading from tablet screen or from paper. The neurovascular coupling was tested also after 15-minute reading from either monitor or paper. Methods: Flow velocity responses evoked by reading from paper and from monitor were measured by transcranial Doppler sonography in a random sequence in both posterior cerebral arteries (PCAs) of 20 young healthy adults. Afterward, PCA flow response evoked by reading from paper was also investigated after 15 minutes reading on the same tablet or paper, in a random order. Results: Reading from monitor with its own source of light and reading from paper with indirect light caused very similar PCA flow response. Moreover, the flow velocity increase, evoked by reading form paper did not differ after 15-minute reading from monitor or from paper. Conclusions: Reading with direct or indirect light produces similar flow response in the occipital cortex.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
neurovascular coupling
reading
transcranial Doppler ultrasonography
Megjelenés:Journal of Clinical Ultrasound. - 47 : 5 (2019), p. 272-277. -
További szerzők:Árokszállási Tamás (1988-) (neurológus) Csiba László (1952-) (neurológus, pszichiáter) Oláh László (1967-) (neurológus)
Pályázati támogatás:2017-1.2.1-NKP- 2017-00002
Egyéb
NAP_13-1-2013-0001
Egyéb
NKFH-K 120042
Egyéb
NKFH-K 109712
Egyéb
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
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