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001-es BibID:	BIBFORM102720
035-os BibID:	(WOS)000817858700001 (Scopus)85133079103
Első szerző:	Farkas Bence
Cím:	Unusual perfusion patterns on perfusion-only SPECT/CT scans in COVID-19 patients / Farkas Bence, Képes Zita, Barna Sándor Kristóf, Szugyiczki Viktória, Bakos Magdolna, Forgács Attila, Garai Ildikó
Dátum:	2022
ISSN:	0914-7187 1864-6433
Megjegyzések:	Purpose We aimed at examining both the incidence and extent of different lung perfusion abnormalities as well as the relationship between them on Tc-99m macroaggregated albumin (MAA) perfusion-only SPECT/CT scans in COVID-19 patients. Methods Ninety-one patients (71.4???13.9 years; range: 29?98 years, median age: 74 years; 45 female and 46 male) with confirmed SARS-CoV-2 virus infection were included in this retrospective study. After performing perfusion-only Tc-99m MAA SPECT/CT scans, visual, semi-quantitative assessment of the subsequent perfusion abnormalities was carried out: mismatch lesions (MM; activity defects on SPECT images identical to apparently healthy parenchyma on CT images), matched lesions (MA; activity defects with corresponding parenchymal lesions on CT scans), and reverse mismatch lesions (RM; parenchymal lesions with preserved or increased tracer uptake). Lesion-based and patient-based analysis were performed to evaluate the extent, severity, and incidence of each perfusion abnormality. Statistical tests were applied to investigate the association between the experienced perfusion impairments. Results Moderately severe parenchymal lesions were detected in 87 (95.6%) patients. Although, 50 (54.95%) patients were depicted to have MM lesions, the whole patient cohort was mildly affected by this abnormality. MA lesions of average moderate severity were seen in most of the patients (89.01%). In 65 (71.43%) patients RM lesions were found with mild severity on average. Positive association was detected between total CT score and total RM score and between total CT score and total MA score. Significantly higher total CT scores were experienced in the subgroup, where RM lesions were present. Conclusions Heterogeneous perfusion abnormalities were found in most of COVID-19 patients: parenchymal lesions with normal, decreased or increased perfusion and perfusion defects in healthy lung areas. These phenomena may be explained by the failure of the hypoxic pulmonary vasoconstriction mechanism and presence of pulmonary thrombosis and embolism.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Annals Of Nuclear Medicine. - 36 : 9 (2022), p. 804-811. -
További szerzők:	Képes Zita (1991-) (orvos) Barna Sándor (1982-) (kutató orvos) Szugyiczki Viktória Bakos Magdolna Forgács Attila (1985-) (fizikus) Garai Ildikó (1966-) (radiológus)
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