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001-es BibID:BIBFORM061303
Első szerző:Krizsán Áron Krisztián (fizikus)
Cím:A Promising Future : comparable Imaging Capability of MRI-Compatible Silicon Photomultiplier and Conventional Photosensor Preclinical PET Systems / Aron K. Krizsan, Imre Lajtos, Magnus Dahlbom, Freddie Daver, Miklos Emri, Sandor A. Kis, Gabor Opposits, Laszlo Pohubi, Norbert Potari, Gyula Hegyesi, Gabor Kalinka, Janos Gal, Jozsef Imrek, Ferenc Nagy, Ivan Valastyan, Beata Kiraly, Jozsef Molnar, Delfo Sanfilippo, Laszlo Balkay
Dátum:2015
ISSN:0161-5505
Megjegyzések:We recently completed construction of a small-animal PET system- the MiniPET-3-that uses state-of-the-art silicon photomultiplier (SiPM) photosensors, making possible dual-modality imaging with MRI. In this article, we compare the MiniPET-3 with the MiniPET-2, a system with the same crystal geometry but conventional photomultiplier tubes (PMTs). Methods: The standard measurements proposed by the National Electrical Manufacturers Association NU 4 protocols were performed on both systems. These measurements included spatial resolution, system sensitivity, energy resolution, counting rate performance, scatter fraction, spillover ratio for air and water, recovery coefficient, and image uniformity. The energy windows were set to 350-650 keV on the MiniPET-2 and 360-662 keV on the MiniPET-3. Results: Spatial resolution was approximately 17% better on average for the MiniPET-3 than the MiniPET-2. The systems performed similarly in terms of peak absolute sensitivity (~1.37%), spillover ratio for air (~0.15), spillover ratio for water (~0.25), and recovery coefficient (~0.33, 0.59, 0.81, 0.89, and 0.94). Uniformity was 5.59% for the MiniPET-2 and 6.49% for the MiniPET-3. Minor differences were found in scatter fraction. With the ratlike phantom, the peak noise-equivalent counting rate was 14 kcps on the MiniPET-2 but 24 kcps on the MiniPET-3. However, with the mouselike phantom, these values were 55 and 91 kcps, respectively. The optimal coincidence time window was 6 ns for the MiniPET-2 and 8 ns for the MiniPET-3. Conclusion: Images obtained with the SiPM-based MiniPET-3 small-animal PET system are similar in quality to those obtained with the conventional PMT-based MiniPET-2.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
MiniPET
small-animal PET scanner
performance evaluation
instrumentation
molecular imaging
Megjelenés:Journal Of Nuclear Medicine 56 : 12 (2015), p. 1948-1953. -
További szerzők:Lajtos Imre (1986-) (fizikus) Dahlbom, Magnus Daver, Freddie Emri Miklós (1962-) (fizikus) Kis Sándor Attila (1973-) (fizikus) Opposits Gábor (1974-) (fizikus, szoftver fejlesztő) Pohubi László (1959-) (fizikus) Pótári Norbert (1980-) (vegyész) Hegyesi Gyula (1963-) (villamosmérnök) Kalinka Gábor Gál János Imrek József (1980-) Nagy Ferenc (1984-) (fizikus) Valastyán Iván (1979-) (fizikus, informatikus) Király Beáta (fizikus) Molnár József Sanfilippo, Delfo Balkay László (1963-) (biofizikus)
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