CCL

Összesen 7 találat.
#/oldal:
Részletezés:
Rendezés:

1.

001-es BibID:BIBFORM117741
035-os BibID:(cikkazonosító)100236 (Scopus)85181231741
Első szerző:Epstein, Richard H.
Cím:Validation of a convolutional neural network that reliably identifies electromyographic compound motor action potentials following train-of-four stimulation : an algorithm development experimental study / Richard H. Epstein, Olivia F. Perez, Ira S. Hofer, J. Ross Renew, Reka Nemes, Sorin J. Brull
Dátum:2023
ISSN:2772-6096
Megjegyzések:Background: International guidelines recommend quantitative neuromuscular monitoring when administering neuromuscular blocking agents. The train-of-four count is important for determining the depth of block and appropriate reversal agents and doses. However, identifying valid compound motor action potentials (cMAPs) during surgery can be challenging because of low-amplitude signals and an inability to observe motor responses. A convolutional neural network (CNN) to classify cMAPs as valid or not might improve the accuracy of such determinations. Methods: We modified a high-accuracy CNN originally developed to identify handwritten numbers. For training, we used digitised electromyograph waveforms (TetraGraph) from a previous study of 29 patients and tuned the model parameters using leave-one-out cross-validation. External validation used a dataset of 19 patients from another study with the same neuromuscular block monitor but with different patient, surgical, and protocol characteristics. All patients underwent ulnar nerve stimulation at the wrist and the surface electromyogram was recorded from the adductor pollicis muscle. Results: The tuned CNN performed highly on the validation dataset, with an accuracy of 0.9997 (99% confidence interval 0.9994?0.9999) and F1 score=0.9998. Performance was equally good for classifying the four individual responses in the train-of-four sequence. The calibration plot showed excellent agreement between the predicted probabilities and the actual prevalence of valid cMAPs. Ten-fold cross-validation using all data showed similar high performance. Conclusions: The CNN distinguished valid cMAPs from artifacts after ulnar nerve stimulation at the wrist with >99.5% accuracy. Incorporation of such a process within quantitative electromyographic neuromuscular block monitors is feasible.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
electromyography
machine learning
neural network
neuromuscular block
train-of-four
Megjelenés:BJA Open. - 8 (2023), p. 1-9. -
További szerzők:Perez, Olivia F. Hofer, Ira S. Renew, J. Ross Nemes Réka (1985-) (aneszteziológus, intenzív terápiás szakorvos) Brull, Sorin J.
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

2.

001-es BibID:BIBFORM112910
035-os BibID:(wos)001011827700001 (scopus)85162693630
Első szerző:Fuchs-Buder, Thomas
Cím:Good clinical research practice (GCRP) in pharmacodynamic studies of neuromuscular blocking agents : The 2023 Geneva revision / Fuchs-Buder Thomas, Brull Sorin J., Fagerlund Malin Jonsson, Renew Ross J., Cammu Guy, Murphy Glenn S., Warlé Michiel, Vested Matias, Fülesdi Béla, Nemes Reka, Columb Malachy O., Damian Daniela, Davis Peter J., Iwasaki Haijme, Eriksson Lars I.
Dátum:2023
ISSN:0001-5172
Megjegyzések:The set of guidelines for good clinical research practice in pharmacodynamic studies of neuromuscular blocking agents was developed following an international consensus conference in Copenhagen in 1996 (Viby-Mogensen et al., Acta Anaesthesiol Scand 1996, 40, 59?74); the guidelines were later revised and updated following the second consensus conference in Stockholm in 2005 (Fuchs-Buder et al., Acta Anaesthesiol Scand 2007, 51, 789?808). In view of new devices and further development of monitoring technologies that emerged since then, (e.g., electromyography, three-dimensional acceleromyography, kinemyography) as well as novel compounds (e.g., sugammadex) a review and update of these recommendations became necessary. The intent of these revised guidelines is to continue to help clinical researchers to conduct high-quality work and advance the field by enhancing the standards, consistency, and comparability of clinical studies. There is growing awareness of the importance of consensus-based reporting standards in clinical trials and observational studies. Such global initiatives are necessary in order to minimize heterogeneous and inadequate data reporting and to improve clarity and comparability between different studies and study cohorts. Variations in definitions of endpoints or outcome variables can introduce confusion and difficulties in interpretation of data, but more importantly, it may preclude building of an adequate body of evidence to achieve reliable conclusions and recommendations. Clinical research in neuromuscular pharmacology and physiology is no exception.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
depth of neuromuscular blockade
neuromuscular monitoring
neuromuscular research
pharmacodynamics
postoperative pulmonary complications
time course of neuromuscular blockade
Megjelenés:Acta Anaesthesiologica Scandinavica. - 67 : 8 (2023), p. 994-1017. -
További szerzők:Brull, Sorin J. Fagerlund, Malin Jonsson Renew, J. Ross Cammu, Guy Murphy, Glenn S. Warlé, Michiel Vested, Matias Fülesdi Béla (1961-) (aneszteziológus) Nemes Réka (1985-) (aneszteziológus, intenzív terápiás szakorvos) Columb, Malachy O. Damian, Daniela Davis, Peter J. Iwasaki, Haijme Eriksson, Lars I.
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

3.

001-es BibID:BIBFORM094422
Első szerző:Iwasaki, Hiroyuki
Cím:Quantitative Neuromuscular Monitoring : current Devices, New Technological Advances, and Use in Clinical Practice / Iwasaki H., Nemes R., Brull S. J., Renew J. R.
Dátum:2018
Megjegyzések:Purpose of Review The purpose of this review is to summarize various quantitative neuromuscular monitoring modalities and describe strategies to implement them into routine practice. We will contrast these objective modalities with unreliable clinical tests and subjective techniques that expose patients to unnecessary risk associated with postoperative residual weakness. Recent Findings As major specialty societies publish guidelines and consensus statements urging anesthesiologists to utilize quantitative monitors, clinicians must familiarize themselves with this equipment. Furthermore, new monitors are emerging as the industry tries to address the need for user-friendly, reliable monitors. Summary Clinical assessment is an unacceptable technique to guide neuromuscular blockade management in patients receiving neuromuscular blocking agents. The use of a peripheral nerve stimulator can provide some information regarding the level of neuromuscular blockade in patients; however, it cannot reliably confirm adequate recovery. The use of objective, quantitative monitoring is an essential practice that helps guide the administration of neuromuscular blocking agents and excludes deleterious postoperative residual weakness.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Current Anesthesiology Reports. - 8 : 1 (2018), p. 1-11. -
További szerzők:Nemes Réka (1985-) (aneszteziológus, intenzív terápiás szakorvos) Brull, Sorin J. Renew, J. Ross
Internet cím:Szerző által megadott URL
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

4.

001-es BibID:BIBFORM096675
035-os BibID:(WoS)000695249600011 (Scopus)85115605217
Első szerző:Nemes Réka (aneszteziológus, intenzív terápiás szakorvos)
Cím:Ipsilateral and Simultaneous Comparison of Responses from Acceleromyography- and Electromyography-based Neuromuscular Monitors / Nemes Réka, Lengyel Szabolcs, Nagy György, Hampton David R., Gray Martyn, Renew J. Ross, Tassonyi Edömér, Fülesdi Béla, Brull Sorin J.
Dátum:2021
ISSN:0003-3022
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Anesthesiology. - 135 : 4 (2021), p. 597-611. -
További szerzők:Lengyel Szabolcs (1971-) (biológus) Nagy György (1986-) (aneszteziológus, intenzív terápiás szakorvos) Hampton, David R. Gray, Martyn Renew, J. Ross Tassonyi Edömér (1940-2022) (aneszteziológus) Fülesdi Béla (1961-) (aneszteziológus) Brull, Sorin J.
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

5.

001-es BibID:BIBFORM094407
Első szerző:Nemes Réka (aneszteziológus, intenzív terápiás szakorvos)
Cím:Physiology of neuromuscular transmission / Réka Nemes, J. Ross Renew, Sorin J. Brull
Dátum:2020
ISBN:978-0-323-56702-2
Tárgyszavak:Orvostudományok Klinikai orvostudományok könyvfejezet
könyvrészlet
Megjelenés:Faust's Anesthesiology Review, 5th Edition / Ed. Terrence L. Trentman, Brantley D. Gaitan, Bhargavi Gali, Rebecca L. Johnson, Jeffrey T. Mueller, Steven H. Rose, Toby N. Weingarten. - p. 91-94. -
További szerzők:Renew, J. Ross Brull, Sorin J.
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
Borító:

6.

001-es BibID:BIBFORM094408
Első szerző:Nemes Réka (aneszteziológus, intenzív terápiás szakorvos)
Cím:Reversal Agents of neuromuscular block / Réka Nemes, J. Ross Renew, Sorin J. Brull
Dátum:2020
ISBN:978-0-323-56702-2
Tárgyszavak:Orvostudományok Klinikai orvostudományok könyvfejezet
könyvrészlet
Megjelenés:Faust's Anesthesiology Review, 5th Edition / Ed. Terrence L. Trentman, Brantley D. Gaitan, Bhargavi Gali, Rebecca L. Johnson, Jeffrey T. Mueller, Steven H. Rose, Toby N. Weingarten. - p. 179-183. -
További szerzők:Renew, J. Ross Brull, Sorin J.
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
Borító:

7.

001-es BibID:BIBFORM094393
Első szerző:Renew, J. Ross
Cím:Belgian anesthesiologists' overconfidence in their perceived understanding of neuromuscular blockade management / Renew J. R., Nemes R., Cammu G., Van de Velde M., Brull S. J., Naguib M.
Dátum:2019
ISSN:0001-5164
Megjegyzések:Background : The incidence of postoperative residual weakness remains unacceptably high and essentially unchanged over decades. It is puzzling why anesthesiologists are resistant to accept the concepts of safe management of neuromuscular blockade and reversal. It appears that pervasive misconceptions regarding appropriate implementation of neuromuscular blockade monitoring and management continue to be a substantial obstacle in addressing this issue. Methods : We conducted a 10-question survey composed of true/false options to determine the respondents' knowledge regarding neuromuscular blockade management. Surveys were made available during an unannounced 90 minute period of a national anesthesiology conference in Belgium. Participants were also asked to rate their confidence in their responses. Results : One hundred and fifty-seven anesthesiologists (69 certified anesthesiologists and 88 anesthesiologistsin- training) completed the 10-question survey. Respondents were correct 72% of the time, yet rated their mean confidence significantly higher as 80%. Conclusions : The surveyed anesthesia providers conveyed overconfidence in their understanding of neuromuscular blockade management. Such misconceptions represent a substantial challenge to improving the standards of neuromuscular blockade management throughout the anesthesia community
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Neuromuscular blockade management
quantitative neuromuscular monitoring
postoperative residual weakness
misconception
overconfidence
Megjelenés:Acta Anaesthesiologica Belgica. - 70 (2019), p. 161-165. -
További szerzők:Nemes Réka (1985-) (aneszteziológus, intenzív terápiás szakorvos) Cammu, Guy Van de Velde, M. Brull, Sorin J. Naguib, Mohamed
Internet cím:Szerző által megadott URL
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Rekordok letöltése1