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001-es BibID:	BIBFORM058676
Első szerző:	Gellén Emese (bőrgyógyász)
Cím:	Diagnostic accuracy of 18F-FDG-PET/CT in early and late stages of high-risk cutaneous malignant melanoma / E. Gellen, O. Santha,E. Janka, I. Juhasz, Z. Peter, I. Erdei, R. Lukacs, N. Fedinecz, L. Galuska, E. Remenyik, G. Emri
Dátum:	2015
ISSN:	0926-9959
Megjegyzések:	The precise role of total body 18 F-fluorodeoxyglucose-positron emission tomography/computed tomography (PET/CT) in the clinical management of patients with cutaneous malignant melanoma (CMM) is not well established.OBJECTIVE:The purpose of this study was to investigate the diagnostic accuracy of PET/CT in early- and late-stage patients with high-risk CMM.METHODS:We retrospectively analysed various imaging, histopathological and clinical data from 97 patients also examined by PET/CT during a 5-year period (2007-2011). Three groups were assessed: stage I/II, resected stage III and unresectable stage III/stage IV.RESULTS:The median follow-up time of living patients was 43.48 ? 19.67 (15-142) months. We observed a high diagnostic accuracy in all stages (91.3%, 92.5% and 96.2% respectively). PET/CT appeared to be reliable diagnostic tool even for the detection of small lymph node metastases. PET/CT was informative in 14 of 19 cases wherein another imaging examination provided inconclusive results regarding lesion dignity. However, PET/CT was less suitable for properly evaluating the dignity of a lung lesion. A true positive scan was twice as likely in clinically negative patients with resected stage III disease than in patients with stage I/II disease (35.9% and 14.5%, P = 0.007).CONCLUSIONS:These results confirm that PET/CT is an important diagnostic tool in the management of patients with high-risk CMM, but it cannot replace the standard of care examinations. More accurate clinicopathological and timing criteria must be defined to best utilize the advantages of this imaging method.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban diagnostic accuracy high-risk CMM PET/CT cutaneous malignant melanoma
Megjelenés:	Journal Of The European Academy Of Dermatology And Venereology 29 : 10 (2015), p. 1938-1944. -
További szerzők:	Sántha Orsolya Janka Eszter Anna (1989-) (bőrgyógyász, népegészségügyi szakember) Juhász István (1956-) (bőrgyógyász, bőrsebész, kozmetológus, klinikai onkológus) Péter Zoltán (1964-) (bőrgyógyász) Erdei Irén (1955-) (bőrgyógyász, aneszteziológus és intenzívterápiás szakorvos) Lukács R. Fedinecz Nikol (radiológus szakorvos) Galuska László (1946-) (belgyógyász, izotópdiagnoszta) Remenyik Éva (1956-) (bőrgyógyász) Emri Gabriella (1972-) (bőrgyógyász, allergológus, onkológus)
Pályázati támogatás:	NK101680 OTKA K105872 OTKA TÁMOP-4.2.2.A-11/1/KONV-2012-0031 TÁMOP
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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