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001-es BibID:	BIBFORM035054
035-os BibID:	PMID:22422303
Első szerző:	Bhattoa Harjit Pal (laboratóriumi szakorvos)
Cím:	Prevalence and seasonal variation of hypovitaminosis D and its relationship to bone metabolism in healthy Hungarian men over 50 years of age : the HunMen Study / H. P. Bhattoa, E. Nagy, C. More, J. Kappelmayer, A. Balogh, E. Kalina, P. Antal-Szalmas
Dátum:	2013
ISSN:	0937-941X
Megjegyzések:	This study reports a high prevalence of hypovitaminosis D and low bone mineral density (BMD) in a healthy Hungarian male cohort over 50 years of age. Men with 25-hydroxyvitamin D levels of <75 nmol/L had a significantly higher 10-year hip and major osteoporotic fracture probability using the country-specific fracture risk assessment (FRAX) algorithm. INTRODUCTION: The aim of this study is to characterize the prevalence and seasonal variation of hypovitaminosis D and its relationship to bone metabolism in healthy Hungarian men over 50 years of age. METHODS: We determined levels of 25-hydroxyvitamin D (25-OH-D), PTH, osteocalcin (OC), C-terminal telopeptides of type-I collagen (CTX-I), procollagen type 1 amino-terminal propeptide (PINP), BMD at L1-L4 (LS) and femur neck (FN), daily dietary calcium intake, and the 10-year probability of hip fracture and a major osteoporotic fracture using the country-specific FRAX algorithm in 206 randomly selected ambulatory men. RESULTS: The mean (range) age of the volunteers was 60 (51-81) years. The prevalence of hypovitaminosis D (25-OH-D, <75 nmol/L) was 52.9%. The mean (range) FRAX hip fracture and FRAX major osteoporotic fracture was 0.8% (0-9.4%) and 3.8% (1.7-16%), respectively. On comparing the vitamin D sufficient to the insufficient group, there was a statistically significant difference between the FRAX hip fracture and FRAX major osteoporotic fracture indexes. There was significant seasonal variation in the vitamin D levels; the lowest levels were measured in winter and the highest in summer. CONCLUSIONS: A high prevalence of hypovitaminosis D and low BMD were observed in the studied Hungarian male population. This is the first study reporting higher 10-year hip and major osteoporotic fracture probability using the country-specific FRAX algorithm in individuals with hypovitaminosis D.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Molekuláris Medicina
Megjelenés:	Osteoporosis International. - 24 : 1 (2013), p. 179-186. -
További szerzők:	Nagy E. Móré Csaba (1971-) (szülész-nőgyógyász) Kappelmayer János (1960-) (laboratóriumi szakorvos) Balogh Ádám (1940-) (szülész-nőgyógyász, endokrinológus szakorvos) Kalina Edit Antal-Szalmás Péter (1968-) (laboratóriumi szakorvos)
Pályázati támogatás:	TÁMOP-4.2.1/B-09/1/KONV-2010-0007 TÁMOP Celluláris hematológia - immunológia
Internet cím:	Szerző által megadott URL elektronikus változat DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM035330
Első szerző:	Móré Csaba (szülész-nőgyógyász)
Cím:	The effects of pregnancy and lactation on bone mineral density / C. More, P. Bettembuk, H. P. Bhattoa, A. Balogh
Dátum:	2001
ISSN:	0937-941X
Megjegyzések:	We performed a prospective study of bone mineral density (BMD) in 38 women during their first full-term pregnancy until 12 months postpartum. BMD measurements at lumbar spine [L2-L4 (LS)] and forearm [distal 33% (RD) and ultradistal (RUD) region of the radius] were made within 3 months before conception, after delivery, and at 6 and 12 months postpartum. In mid-pregnancy the DXA examination was carried out only at the forearm. Patients were grouped according to duration of lactation as group I, II or III (0-1, 1-6, 6-12 months respectively). During pregnancy there was a significant difference between baseline and delivery (p<0.001) in the LS, RUD and RD BMD values. In group I there was no statistically significant difference in LS BMD between visits following pregnancy. The RUD BMD loss was recovered by 6 months postpartum (PP6). Group II showed continuous bone loss from delivery until PP6 at LS and RUD. In group III the LS BMD loss continued throughout the lactation period. The RUD BMD dropped (4.9%) until PP6 then increased by 3.0% as measured at 12 months postpartum (PP12). There was no significant change in RD BMD in any of three groups during lactation. At LS bone loss between delivery and PP12 correlated well with the duration of lactation (r=-0.727; p<0.001). We suggest that calcium needed for fetal skeletal growth during pregnancy was gained from maternal trabecular and cortical sites and that calcium needed for infant growth during lactation was drawn mainly from the maternal trabecular skeleton in our patients. The effect of pregnancy and lactation on the maternal bone mass was spontaneously compensated after weaning.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Bone mineral density Lactation Pregnancy adult article bone atrophy bone density bone growth bone mineralization calcium mobilization controlled study cortical bone dual energy X ray absorptiometry female fetus growth human lactation lumbar spine pregnancy priority journal puerperium trabecular bone weaning Adult Bone Density Densitometry, X-Ray Female Humans Lactation Pregnancy Prospective Studies egyetemen (Magyarországon) készült közlemény
Megjelenés:	Osteoporosis International. - 12 : 9 (2001), p. 732-737. -
További szerzők:	Bettembuk Péter Bhattoa Harjit Pal (1973-) (laboratóriumi szakorvos) Balogh Ádám (1940-) (szülész-nőgyógyász, endokrinológus szakorvos)
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