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001-es BibID:BIBFORM078708
035-os BibID:(PMID)31055145 (WoS)000471093600002 (Scopus)85065709699
Első szerző:Orosz László (szülész-nőgyógyász)
Cím:Screening for preeclampsia in the first trimester of pregnancy in routine clinical practice in Hungary / Laszlo Orosz, Gergo Orosz, Lajos Veress, Diana Dosa, Laszlo id. Orosz, Ibolya Arany, Antal Fabian, Laszlo Medve, Karoly Pap, Zsolt Karanyi, Zoltan Toth, Robert Poka, Nandor Gabor Than, Olga Torok
Megjegyzések:We aimed to evaluate the contribution of different factors in the Fetal Medicine Foundation algorithms for preeclampsia (PE) risk calculation during first-trimester screening in Hungary. We selected subjects for the nested case-control study from a prospective cohort of 2,545 low-risk pregnancies. Eighty-two patients with PE and 82 gestational age-matched controls were included. Individual PE risk was calculated using two risk-assessing softwares. Using Astraia 2.3.1, considering maternal characteristics and biophysical parameters only, detection rates (DR) were 63.6% for early-PE and 67.6% for late-PE. When we added placenta associated plasma protein A (PAPP-A) to the risk calculation, DRs decreased to 54.5% and 64.8% respectively. Using Astraia 2.8.2 with maternal characteristics and biophysical parameters resulted in the DRs of 63.6% (early-PE) and 56.3% (late-PE). If we added PAPP-A to the risk calculation, DRs improved to 72.7% and 54.9%. The addition of placental growth factor (PlGF) did not increase detection rates in either calculation. In conclusion, using maternal characteristics, biophysical parameters, and PAPP-A, an acceptable screening efficacy could be achieved for early-PE during first-trimester screening. Since PlGF did not improve efficacy in our study, we suggest setting new standard curves for PlGF in Eastern European pregnant women, and the evaluation of novel biochemical markers.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Blood pressure
First trimester
Placental growth factor
Uterine artery Doppler
Megjelenés:Journal Of Biotechnology. - 300 (2019), p. 11-19. -
További szerzők:Orosz Gergő Balázs (1985-) (szülész-nőgyógyász) Veress Lajos (1950-) (vegyész) Dósa Diána id. Orosz László Arany Ibolya Fábián Antal Medve László Pap Károly Karányi Zsolt (1961-) (biostatisztikus, bioinformatikus) Tóth Zoltán (1948-) (szülész-nőgyógyász, humángenetikus) Póka Róbert (1960-) (szülész-nőgyógyász, klinikai onkológus) Than Nándor Gábor (szülész-nőgyógyász) Török Olga (1956-) (szülész-nőgyógyász, humángenetikus)
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001-es BibID:BIBFORM068400
Első szerző:Orosz László (szülész-nőgyógyász)
Cím:Screening for pre-eclampsia during the first trimester in routine clinical practice : a prospective study / Orosz, L., Orosz, G., id. Orosz, L., Fabian, A., Tóth, Z., Török, O.
Megjegyzések:ObjectivesThe association between pre-eclamsia (PE) and first trimester high uterine artery pulsatility index (UtA-PI), low maternal serum pregnancy-associated plasma protein-A (PAPP-A) level and certain maternal factors is well known. Several retrospective studies have shown that these first trimester markers can predict PE with a detection rate of 60?90%. The aim of this prospective study was to determine the performance of screening for PE in singleton pregnancies during routine clinical practice.MethodsBetween 2011?2012 measurements of UtA-PI were performed at 11?13 + 6 weeks, and mean pulsatility index (PI) was calculated. Doppler, maternal history and biometry variables (age, ethnic origin, method of conception, BMI, parity, smoking, family or personal history of hypertension or PE, blood pressure) were combined with first trimester PAPP-A to assess the risk of PE. Astraia Software 2.3.2 was used in risk calculation.Results2552 women were recruited after informed consent to the study, and outcome data were available in 950 (37.2%) cases. PE occurred in 36 (3.8%) patients. The overall detection rate of early and late PE was 44.4% (16/36) with a false positive rate (FPR) of 12.3% (112/914). There were only 2 cases with early PE, the detection rate was 50% (1/2), with a FPR of 18.7% (178/948). The detection rate of the late PE (delivery at 34th weeks or after) was 44.1% (15/34), with a FPR of 9.5% (87/914).ConclusionsCombining risk factors in the mother's history with UtA-PI allows calculation of patient-specific risk for the development of PE. Because of the small number of early PE cases in our study population our detection rate can not be taken into consideration. The detection rate (44%) of late PE in our study is comparable with the published retrospective data (60%). The Astraia software used only serum PAPP-A for risk calculation. Further biochemical markers might improve the detection rate. Follow-up of our recruited cases is still going on.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
Screening for preeclampsia
Megjelenés:Ultrasound In Obstetrics & Gynecology. - 40 : S1 (2012), p. 199-200. -
További szerzők:Orosz Gergő Balázs (1985-) (szülész-nőgyógyász) id. Orosz László Fábián Anna Tóth Zoltán (1948-) (szülész-nőgyógyász, humángenetikus) Török Olga (1956-) (szülész-nőgyógyász, humángenetikus)
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