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1.

001-es BibID:BIBFORM030581
Első szerző:Haller J.
Cím:Compression of the pituitary stalk elicits chronic increases in CSF vasopressin, oxytocin as well as in social investigation and aggressiveness / J. Haller, G. B. Makara, I. Barna, K. Kovács, J. Nagy, M. Vecsernyés
Dátum:1996
ISSN:0953-8194
Megjegyzések:The neurochemical and behavioural effects of a novel stereotaxic surgical method developed for interrupting the nerve fibres running through the rat pituitary stalk to the posterior pituitary gland was studied. The cerebrospinal fluid (CSF) vasopressin (AVP) and oxytocin (OT) content as well as changes in aggressiveness were measured in rats one week and one month after the surgical intervention. The main results are as follows: (1) the compression of the pituitary stalk elicits a chronic increase in water consumption, as well as in CSF vasopressin and oxytocin content; (2) the surgical intervention increased the frequency of clinch fighting after one week. The increase in aggressiveness accentuated after one month and, in addition, operated animals showed reduced scores of resting while exploratory and social behaviours increased; (3) there was a strong positive correlation between water consumption, vasopressin, and aggressiveness; (4) oxytocin changes showed a positive correlation with variation in social behaviour. The surgical intervention may serve as a model for lesions of the pituitary stalk and formation of ectopic neurohypophyses in humans.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
pituitary
arginine vasopressin
oxytocin
aggression
social behaviour
diabetes insipidus
egyetemen (Magyarországon) készült közlemény
Megjelenés:Journal of Neuroendocrinology. - 8 : 5 (1996), p. 361-365. -
További szerzők:Makara Gábor B. Barna I. Kovács K. (Budapest) Nagy J. (Budapest) Vecsernyés Miklós (1959-) (gyógyszertechnológus, endokrinológus)
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2.

001-es BibID:BIBFORM032024
Első szerző:Nagy György M.
Cím:Dehydration decreases plasma level of [alpha]-melanocyte-stimulating hormone ([alpha]-msh) and attenuates suckling-induced [beta]-endorphin but not ACTH response in lactating rats / György M. Nagy, Miklós Vecsernyés, János Julesz, István Barna, James I. Koenig
Dátum:1994
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Neuroendocrinology Letters. - 16 : 5-6 (1994), p. 275-284. -
További szerzők:Vecsernyés Miklós (1959-) (gyógyszertechnológus, endokrinológus) Julesz János Barna István Koenig, James I.
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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3.

001-es BibID:BIBFORM013981
Első szerző:Oláh Márk
Cím:Dopamine-Regulated Adrenocorticotropic Hormone Secretion in Lactating Rats : functional Plasticity of Melanotropes / Oláh Márk, Fehér Pálma, Ihm Zsófia, Bácskay Ildikó, Kiss Timea, Freeman Marc E., Nagy György M., Vecsernyés Miklós
Dátum:2009
ISSN:0028-3835
Megjegyzések:AbstractPro-opiomelanocortin (POMC) is processed to adrenocorticotropic hormone (ACTH) and beta-lipotropin in corticotropes of the anterior lobe, and to alpha-melanocyte-stimulating hormone (alpha-MSH) and beta-endorphin in melanotropes of the intermediate lobe (IL) of the pituitary gland. While ACTH secretion is predominantly under the stimulatory influence of the hypothalamic factors, hormone secretion of the IL is tonically inhibited by neuroendocrine dopamine (NEDA) neurons. Lobe-specific POMC processing is not absolute. For example, D(2) type DA receptor (D2R)-deficient mice have elevated plasma ACTH levels, although it is known that corticotropes do not express D2R(s). Moreover, observations that suckling does not influence alpha-MSH release, while it induces an increase in plasma ACTH is unexplained. The aim of the present study was to investigate the involvement of the NEDA system in the regulation of ACTH secretion and the participation of the IL in ACTH production in lactating rats. Untreated and estradiol (E(2))-substituted ovariectomized (OVX) females were also studied. The concentration of ACTH in the IL was higher in lactating rats than in OVX rats, while the opposite change in alpha-MSH level of the IL was observed. DA levels in the IL and the neural lobe were lower in lactating rats than in OVX rats. Suckling-induced ACTH response was eliminated by pretreatment with the DA receptor agonist, bromocriptine (BRC). Inhibition of DA biosynthesis by alpha-methyl-p-tyrosine (alphaMpT) and blockade of D2R by domperidone (DOM) elevated plasma ACTH levels, but did not influence plasma alpha-MSH levels in lactating rats. The same drugs had opposite effects in OVX and OVX + E(2) animals. In lactating mothers, BRC was able to block ACTH responses induced by both alphaMpT and DOM. Surgical denervation of the IL elevated basal plasma levels of ACTH. Taken together, these data indicate that melanotropes synthesize ACTH during lactation and its release from these cells i
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
dopamine
Megjelenés:Neuroendocrinology. - 90 : 4 (2009), p. 391-401. -
További szerzők:Fehér Pálma (1976-) (gyógyszerész) Ihm Zsófia Bácskay Ildikó (1969-) (gyógyszerész, gyógyszertechnológus) Kiss Tímea (1983-) (gyógyszerész) Freeman, Marc E. Nagy György M. Vecsernyés Miklós (1959-) (gyógyszertechnológus, endokrinológus)
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DOI
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4.

001-es BibID:BIBFORM030627
Első szerző:Sarnyai Zoltán
Cím:Effects of cocaine and pimozide on plasma and brain alpha-melanocyte-stimulating hormone levels in rats / Zoltán Sarnyai, Miklós Vecsernyés, János Julesz, Gyula Szabó, Gyula Telegdy
Dátum:1992
ISSN:0028-3835
Megjegyzések:The effects of cocaine on rat plasma and brain alpha-melanocyte-stimulating hormone (alpha-MSH) levels have been studied by means of a specific radioimmunoassay. The selected brain areas were the hypothalamus, septum-nucleus accumbens and hippocampus. Cocaine given subcutaneously decreased the alpha-MSH levels in the peripheral blood. Pimozide, a dopaminergic antagonist, had an opposite effect: it increased the alpha-MSH levels in the peripheral blood. Combined treatment with cocaine + pimozide resulted in a decrease in the pimozide-induced increase in alpha-MSH levels in the blood. Cocaine and pimozide or the combination of cocaine + pimozide were ineffective on the alpha-MSH levels in the hypothalamus and septum-accumbens brain regions. In the hippocampus, cocaine in the dose applied induced a slight but not significant decrease in the alpha-MSH level. Pimozide caused a significant decrease in the hippocampal alpha-MSH level which disappeared at 60 min. Cocaine prevented the pimozide-induced depletion of alpha-MSH. The data indicate that cocaine may act as a dopaminergic agonist in the mechanism of control of alpha-MSH secretion from the intermediate lobe of the pituitary. The alpha-MSH levels in the brain are controlled by different mechanisms. In some brain areas, the dopaminergic system has no action; in others the mechanisms might be similar to but slightly different from that in the pituitary.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
cocaine
pimozine
alpha-melanocyte-stimulating hormone
egyetemen (Magyarországon) készült közlemény
Megjelenés:Neuroendocrinology 55 : 1 (1992), p. 9-13. -
További szerzők:Vecsernyés Miklós (1959-) (gyógyszertechnológus, endokrinológus) Julesz János Szabó Gyula (Szeged) Telegdy Gyula (Szeged)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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5.

001-es BibID:BIBFORM031973
Első szerző:Tóth E. Béla (orvos)
Cím:Salsolinol is putative endogenous Neuro-intermediate lobe prolactin-releasing factor / Tóth B. E., Homicskó K., Radnai B., Maruyama W., DeMaria J. E., Vecsernyés M., Fekete M. I. K., Fülöp F., Naoi M., Freeman M. E., Nagy G. M.
Dátum:2001
ISSN:0953-8194
Megjegyzések:The isolation and identification of a prolactin-releasing factor (PRF) from the neuro-intermediate lobe of the pituitary gland has been pursued for over a decade. Using high-pressure liquid chromatography with electrochemical detection (HPLC-ECD) and gas chromatography/mass spectrometry (GC/MS) (R)-salsolinol (SAL) (a dopamine-related stereo-specific tetrahydroisoquinoline) was found to be present in neuro-intermediate lobe as well as median eminence extracts of male, intact-, and ovariectomized female rats. Moreover, analysis of SAL concentrations in neuro-intermediate lobe revealed parallel increases with plasma prolactin in lactating rats exposed to a brief (10 min) suckling stimulus following 4-h separation. SAL appears to be a selective and potent stimulator of prolactin secretion in vivo and it was without effect on the secretion of other pituitary hormones. We have also found that SAL can elevate prolactin release, although to a lesser extent, in pituitary cell cultures as well as in hypophysectomized rats bearing anterior lobe transplants under the kidney capsule. Lack of interference of SAL with [3H]-spiperone binding to AP homogenates indicates that SAL does not act at the dopamine D2 receptor. Moreover, [3H]-SAL binds specifically to homogenate of AL as well as neuro-intermediate lobe obtained from lactating rats. Taken together, our data clearly suggest that SAL is synthesized in situ and this compound can play a role in the regulation of pituitary prolactin secretion.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Of Neuroendocrinology 13 : 12 (2001), p. 1042-1050. -
További szerzők:Homicskó Krisztián Gy. Radnai Balázs Maruyama W. DeMaria, Jamie E. Vecsernyés Miklós (1959-) (gyógyszertechnológus, endokrinológus) Fekete I. K. Márton Fülöp Ferenc Naoi, M. Freeman, Marc E. Nagy György M.
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