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1.

001-es BibID:BIBFORM032098
Első szerző:Bodnár Ibolya
Cím:Effect of neonatal treatment with monosodium glutamate on dopamine and DOPA neurons in the medial basal hypothalamus of rats / Ibolya Bodnár, Dániel Szekács, Márk Oláh, Hitoshi Okamura, Miklós Vecsernyés, Marton I. K. Fekete, György M. Nagy
Dátum:2006
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok könyvfejezet
egyetemen (Magyarországon) készült közlemény
Megjelenés:Neurobiology of DOPA as a neurotransmitter / [written by] Yoshimi Misu, Yoshio Goshima. - p. 340-349.
További szerzők:Szekács Dániel Oláh Márk Okamura, Hitoshi Vecsernyés Miklós (1959-) (gyógyszertechnológus, endokrinológus) Fekete I. K. Márton Nagy M. György
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2.

001-es BibID:BIBFORM013978
Első szerző:Fehér Pálma (gyógyszerész)
Cím:Dephosphorylation/inactivation of tyrosine hydroxylase at the median eminence of the hypothalamus is required for suckling-induced prolactin and adrenocorticotrop hormone responses / Fehér Pálma, Oláh Márk, Bodnár Ibolya, Hechtl Dániel, Bácskay Ildikó, Juhász Béla, Nagy György M., Vecsernyés Miklós
Dátum:2010
ISSN:0361-9230
Megjegyzések:Wehave recently found that dopamine (DA) released from terminals of the hypothalamic neuroendocrine dopamine (NEDA) neurons plays a role not only in prolactin (PRL), but also in adrenocorticotrop hormone (ACTH) secretion, without having any influence on alfa-melanocyte-stimulating hormone (alfa-MSH) release in lactating dams. The aim of our present studies was to further investigate this DAerg regulation of ACTH using consecutively applied physiological stimulation (suckling) and pharmacological inhibition of the rate-limiting enzyme of DA synthesis (tyrosine hydroxylase, TH) by alfa-methyl-p-tyrosine (alfa-MpT) that acutely affect secretion of these pituitary hormones during lactation. Following 4 h separation period, two experimental groups were formed. In the first group, lactating rats were assembled with their litters for 60 min prior to alfa-MpT. In the second group, the alfa-MpT was injected first and 60 min later suckling stimulus was applied. Plasma samples were taken in every 15 min during the 90 min experimental period. Concentrations of plasma PRL, ACTH and alfa-MSH were measured by specific RIAs. Both stimuli applied in the first sequence, significantly elevated plasma PRL and ACTH levels in separated lactating dams, without having any effect on alfa-MSH secretion. Suckling applied in the first sequence was able to block the alfa-MpT-induced elevation of ACTH secretion, while PRL response was also significantly attenuated. alfa-MpT pretreatment prevented both PRL and ACTH responses to suckling stimulus. Investigating the dephosphorylation/inactivation of TH in the arcuate nucleus-ME (TIDA) regions, no pTH-immunoreactive perikarya or terminals can be found in continuously suckled dams. In contrast, after 4 h separation of the mothers from their litters, pTH-immunoreactivity can be clearly visualized in the external zone of ME. In alfa-MpT pretreated mothers following 4 h separation no pTH positive terminals are visible. No changes in the TH immunostaining can be observed in any of these experimental groups. In conclusion, dephosphorylation/inactivation of TH (the rate-limiting enzyme of the DA biosynthesis) in NEDA neurons is required for suckling-induced PRL and ACTH responses.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
prolactin
Megjelenés:Brain Research Bulletin. - 82 : 1-2 (2010), p. 141-145. -
További szerzők:Oláh Márk Bodnár Ibolya Hechtl Dániel Bácskay Ildikó (1969-) (gyógyszerész, gyógyszertechnológus) Juhász Béla (1978-) (kísérletes farmakológus) Nagy György M. Vecsernyés Miklós (1959-) (gyógyszertechnológus, endokrinológus)
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3.

001-es BibID:BIBFORM073665
Első szerző:Oláh Márk
Cím:Role of salsolinol in the regulation of pituitary prolactin and peripheral dopamine release / Márk Oláh, Ibolya Bodnár, Galit Daniel, Béla E. Tóth, Miklós Vecsernyés, György M. Nagy
Dátum:2011
ISSN:1445-5781 1447-0578
Megjegyzések:(R)?Salsolinol (SAL), a dopamine (DA)?related tetrahydroisoquinoline, has been found in extracts of the neuro?intermediate lobes (NIL) of pituitary glands and in the median eminence of the hypothalamus obtained from intact male rats and from ovariectomized and lactating female rats. Moreover, analysis of SAL concentrations in NIL revealed parallel increases with plasma prolactin (PRL) in lactating rats exposed to a brief (10 min) suckling stimulus after 4?h separation. SAL is sufficiently potent in vivo to account for the massive discharge of PRL that occurs after physiological stimuli (i.e. suckling). At the same time, it was without effect on the secretion of other pituitary hormones. It has been also shown that another isoquinoline derivative, 1?methyldihydroisoquinoline (1MeDIQ), which is a structural analogue of SAL, can dose?dependently inhibit the in?vivo PRL?releasing effect of SAL. Moreover, 1MeDIQ can inhibit the elevation of plasma PRL induced by physiological stimuli, for example suckling, or in different stressful situations also. 1MeDIQ also has a psycho?stimulant action, which is fairly similar to the effect of amphetamine, i.e. it induces an increase in plasma catecholamine concentrations. It is clear from these data that this newly discovered endogenous compound could be involved in regulation of pituitary PRL secretion. It has also been observed that SAL is present in peripheral, sympathetically innervated organs, for example the atrium, spleen, liver, ovaries, vas deferens, and salivary gland. Furthermore, SAL treatment of rats results in dose?dependent and time?dependent depletion of the DA content of the organs listed above without having any effect on the concentration of norepinephrine. More importantly, this effect of SAL can be completely prevented by amphetamine and by 1MeDIQ pretreatment. It is clear there is a mutual interaction between SAL, 1MeDIQ, and amphetamine or alcohol, not only on PRL release; their interaction with catecholamine "synthesis/metabolism" of sympathetic nerve terminals is also obvious.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Reproductive Medicine and Biology 10 : 3 (2011), p. 143-151. -
További szerzők:Bodnár Ibolya Daniel, Galit Tóth E. Béla (1960-) (orvos) Vecsernyés Miklós (1959-) (gyógyszertechnológus, endokrinológus) Nagy György M.
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4.

001-es BibID:BIBFORM013981
Első szerző:Oláh Márk
Cím:Dopamine-Regulated Adrenocorticotropic Hormone Secretion in Lactating Rats : functional Plasticity of Melanotropes / Oláh Márk, Fehér Pálma, Ihm Zsófia, Bácskay Ildikó, Kiss Timea, Freeman Marc E., Nagy György M., Vecsernyés Miklós
Dátum:2009
ISSN:0028-3835
Megjegyzések:AbstractPro-opiomelanocortin (POMC) is processed to adrenocorticotropic hormone (ACTH) and beta-lipotropin in corticotropes of the anterior lobe, and to alpha-melanocyte-stimulating hormone (alpha-MSH) and beta-endorphin in melanotropes of the intermediate lobe (IL) of the pituitary gland. While ACTH secretion is predominantly under the stimulatory influence of the hypothalamic factors, hormone secretion of the IL is tonically inhibited by neuroendocrine dopamine (NEDA) neurons. Lobe-specific POMC processing is not absolute. For example, D(2) type DA receptor (D2R)-deficient mice have elevated plasma ACTH levels, although it is known that corticotropes do not express D2R(s). Moreover, observations that suckling does not influence alpha-MSH release, while it induces an increase in plasma ACTH is unexplained. The aim of the present study was to investigate the involvement of the NEDA system in the regulation of ACTH secretion and the participation of the IL in ACTH production in lactating rats. Untreated and estradiol (E(2))-substituted ovariectomized (OVX) females were also studied. The concentration of ACTH in the IL was higher in lactating rats than in OVX rats, while the opposite change in alpha-MSH level of the IL was observed. DA levels in the IL and the neural lobe were lower in lactating rats than in OVX rats. Suckling-induced ACTH response was eliminated by pretreatment with the DA receptor agonist, bromocriptine (BRC). Inhibition of DA biosynthesis by alpha-methyl-p-tyrosine (alphaMpT) and blockade of D2R by domperidone (DOM) elevated plasma ACTH levels, but did not influence plasma alpha-MSH levels in lactating rats. The same drugs had opposite effects in OVX and OVX + E(2) animals. In lactating mothers, BRC was able to block ACTH responses induced by both alphaMpT and DOM. Surgical denervation of the IL elevated basal plasma levels of ACTH. Taken together, these data indicate that melanotropes synthesize ACTH during lactation and its release from these cells i
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
dopamine
Megjelenés:Neuroendocrinology. - 90 : 4 (2009), p. 391-401. -
További szerzők:Fehér Pálma (1976-) (gyógyszerész) Ihm Zsófia Bácskay Ildikó (1969-) (gyógyszerész, gyógyszertechnológus) Kiss Tímea (1983-) (gyógyszerész) Freeman, Marc E. Nagy György M. Vecsernyés Miklós (1959-) (gyógyszertechnológus, endokrinológus)
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5.

001-es BibID:BIBFORM030660
Első szerző:Radnai Balázs
Cím:Salsolinol induces a decrease in cyclic AMP at the median eminence and an increase at the adenohypophysis in lactating rats / Balázs Radnai, Zoltán Kandár, Anikó Somogyvári-Vigh, Zsuzsanna Mergl, Márk Oláh, Ferenc Fülöp, Miklós Vecsernyés, György M. Nagy
Dátum:2005
ISSN:0361-9230
Megjegyzések:Investigating the cellular events in the pituitary gland, the intracellular cyclic AMP (cAMP) of the median eminence (ME), neuro-intermediate lobe (NIL) and the anterior lobe (AL) have been measured following 15-min of intravenous injection of salsolinol (SAL). Parallel to the elevation of plasma prolactin (PRL), SAL induced a significant decrease of cAMP concentration in the ME. In contrast, SAL injection resulted in a significant increase of cAMP at the level of the AL. Changes in cAMP of the NIL as well as in the plasma level of vasopressin (VP) could not be detected. The observed changes in the level of cAMP following the acute treatment of SAL in the ME and the AL seems to be related to interacting neuroendocrine signals delivered from the ME to the AL through the long portal vessels to release PRL.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
pituitary gland
prolactin
tetrahydroisoquinoline
vasopressin
egyetemen (Magyarországon) készült közlemény
Megjelenés:Brain Research Bulletin 65 : 2 (2005), p. 105-110. -
További szerzők:Kandár Zoltán Somogyvári-Vigh Anikó Mergl Zsuzsanna Oláh Márk Fülöp Ferenc (Szeged) Vecsernyés Miklós (1959-) (gyógyszertechnológus, endokrinológus) Nagy György M.
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6.

001-es BibID:BIBFORM073662
Első szerző:Reinhoffer Viktória
Cím:The Regulation of Pituitary Prolactin Secretion : Hypothalamic, Intrapituitary and Intracellular Factors and Signaling Mechanisms / Viktória Reinhoffer, Márk Oláh, Miklós Vecsernyés, Béla E. Tóth, György M. Nagy
Dátum:2013
ISBN:978 953 51 0943 3
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok könyvfejezet
Megjelenés:Prolactin / Nagy M. György, Tóth E. Béla. - p. 167-194. -
További szerzők:Oláh Márk Vecsernyés Miklós (1959-) (gyógyszertechnológus, endokrinológus) Tóth E. Béla (1960-) (orvos) Nagy György M.
Pályázati támogatás:OTKA-81522
OTKA
TÁMOP-4.2.2.A-11/1/KONV-2012-0025
TÁMOP
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