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1.

001-es BibID:BIBFORM032098
Első szerző:Bodnár Ibolya
Cím:Effect of neonatal treatment with monosodium glutamate on dopamine and DOPA neurons in the medial basal hypothalamus of rats / Ibolya Bodnár, Dániel Szekács, Márk Oláh, Hitoshi Okamura, Miklós Vecsernyés, Marton I. K. Fekete, György M. Nagy
Dátum:2006
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok könyvfejezet
egyetemen (Magyarországon) készült közlemény
Megjelenés:Neurobiology of DOPA as a neurotransmitter / [written by] Yoshimi Misu, Yoshio Goshima. - p. 340-349.
További szerzők:Szekács Dániel Oláh Márk Okamura, Hitoshi Vecsernyés Miklós (1959-) (gyógyszertechnológus, endokrinológus) Fekete I. K. Márton Nagy M. György
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2.

001-es BibID:BIBFORM030625
Első szerző:Bodnár Ibolya
Cím:Effect of neonatal treatment with monosodium glutamate on dopaminergic and L-DOPA-ergic neurons of the medial basal hypothalamus and on prolactin and MSH secretion of rats / Ibolya Bodnár, Pál Göőz, Hitoshi Okamura, Béla E. Tóth, Miklós Vecsernyés, Béla Halász, György M. Nagy
Dátum:2001
ISSN:0361-9230
Megjegyzések:The effect of neonatal treatment with monosodium L-glutamate (MSG) on the dopaminergic systems of the medial basal hypothalamus has been investigated using tyrosine hydroxylase (TH) and aromatic L-amino acid decarboxylase (AADC) immunocytochemistry. Changes in plasma levels of prolactin (PRL) and alpha-melanocyte-stimulating hormone (MSH) have also been determined in intact and in MSG-treated rats after inhibition of TH by alpha-methyl-p-tyrosine (alpha-MpT) or without inhibition of enzyme activity. Monosodium glutamate resulted in a 40% reduction in the number of TH immunopositive tuberoinfundibular neurons, but no change in the number of AADC-positive tuberoinfundibular nerve cells, indicating that this reduction has occurred mainly in TH-positive but AADC-negative elements, i.e., in L-DOPA-ergic neurons. In contrast, MSG did not cause changes in the number of TH and AADC immunoreactive neurons of the periventriculohypophysial and tuberohypophysial dopaminergic systems, and it did not influence basal plasma PRL levels. alpha-methyl-p-tyrosine has increased plasma PRL concentrations in both control and MSG-treated rats of both sexes, but significantly higher responses were detected in females. None of the treatments had any effect on plasma MSH level. These findings suggest that MSG affects primarily L-DOPA-ergic neurons located in the ventrolateral part of the arcuate nucleus, but not dopaminergic neurons situated in the dorsomedial part of the arcuate nucleus; neither PRL nor MSH secretion is altered by MSG; a significant sex difference exists in the pituitary PRL response to inhibition of TH, and this response is not affected by MSG.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
arcuate nucleus
tyrosine hydroxylase
aromatic L-amino acid decarboxylase
immunocytochemistry
Megjelenés:Brain Research Bulletin 55 : 6 (2001), p. 767-774. -
További szerzők:Göőz Pál Okamura, Hitoshi Tóth E. Béla (1960-) (orvos) Vecsernyés Miklós (1959-) (gyógyszertechnológus, endokrinológus) Halász Béla Nagy György M.
Pályázati támogatás:T-30748
OTKA
T-029004
OTKA
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3.

001-es BibID:BIBFORM013978
Első szerző:Fehér Pálma (gyógyszerész)
Cím:Dephosphorylation/inactivation of tyrosine hydroxylase at the median eminence of the hypothalamus is required for suckling-induced prolactin and adrenocorticotrop hormone responses / Fehér Pálma, Oláh Márk, Bodnár Ibolya, Hechtl Dániel, Bácskay Ildikó, Juhász Béla, Nagy György M., Vecsernyés Miklós
Dátum:2010
ISSN:0361-9230
Megjegyzések:Wehave recently found that dopamine (DA) released from terminals of the hypothalamic neuroendocrine dopamine (NEDA) neurons plays a role not only in prolactin (PRL), but also in adrenocorticotrop hormone (ACTH) secretion, without having any influence on alfa-melanocyte-stimulating hormone (alfa-MSH) release in lactating dams. The aim of our present studies was to further investigate this DAerg regulation of ACTH using consecutively applied physiological stimulation (suckling) and pharmacological inhibition of the rate-limiting enzyme of DA synthesis (tyrosine hydroxylase, TH) by alfa-methyl-p-tyrosine (alfa-MpT) that acutely affect secretion of these pituitary hormones during lactation. Following 4 h separation period, two experimental groups were formed. In the first group, lactating rats were assembled with their litters for 60 min prior to alfa-MpT. In the second group, the alfa-MpT was injected first and 60 min later suckling stimulus was applied. Plasma samples were taken in every 15 min during the 90 min experimental period. Concentrations of plasma PRL, ACTH and alfa-MSH were measured by specific RIAs. Both stimuli applied in the first sequence, significantly elevated plasma PRL and ACTH levels in separated lactating dams, without having any effect on alfa-MSH secretion. Suckling applied in the first sequence was able to block the alfa-MpT-induced elevation of ACTH secretion, while PRL response was also significantly attenuated. alfa-MpT pretreatment prevented both PRL and ACTH responses to suckling stimulus. Investigating the dephosphorylation/inactivation of TH in the arcuate nucleus-ME (TIDA) regions, no pTH-immunoreactive perikarya or terminals can be found in continuously suckled dams. In contrast, after 4 h separation of the mothers from their litters, pTH-immunoreactivity can be clearly visualized in the external zone of ME. In alfa-MpT pretreated mothers following 4 h separation no pTH positive terminals are visible. No changes in the TH immunostaining can be observed in any of these experimental groups. In conclusion, dephosphorylation/inactivation of TH (the rate-limiting enzyme of the DA biosynthesis) in NEDA neurons is required for suckling-induced PRL and ACTH responses.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
prolactin
Megjelenés:Brain Research Bulletin. - 82 : 1-2 (2010), p. 141-145. -
További szerzők:Oláh Márk Bodnár Ibolya Hechtl Dániel Bácskay Ildikó (1969-) (gyógyszerész, gyógyszertechnológus) Juhász Béla (1978-) (kísérletes farmakológus) Nagy György M. Vecsernyés Miklós (1959-) (gyógyszertechnológus, endokrinológus)
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4.

001-es BibID:BIBFORM066180
035-os BibID:(cikkazonosító)GP121
Első szerző:Nagy György M.
Cím:Expression of dopamine (DA) D2 receptors (D2R) in corticotroph cells is responsible for the switch of hypothalamic regulation of ACTH secretion to DA in lactating rats / György M. Nagy, Pálma Fehér, Ibolya Bodnár, Reid Luke, Zsuzsanna E. Tóth, Miklós Vecsernyés, Béla E. Tóth
Dátum:2016
ISSN:1470-3947 1479-6848
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok poszter
folyóiratcikk
Megjelenés:Endocrine Abstracts. - 41 (2016), p. 1. -
További szerzők:Fehér Pálma (1976-) (gyógyszerész) Bodnár Ibolya Luke, Reid Tóth Zsuzsanna (1977-) (kardiológus) Vecsernyés Miklós (1959-) (gyógyszertechnológus, endokrinológus) Tóth E. Béla (1960-) (orvos)
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5.

001-es BibID:BIBFORM073665
Első szerző:Oláh Márk
Cím:Role of salsolinol in the regulation of pituitary prolactin and peripheral dopamine release / Márk Oláh, Ibolya Bodnár, Galit Daniel, Béla E. Tóth, Miklós Vecsernyés, György M. Nagy
Dátum:2011
ISSN:1445-5781 1447-0578
Megjegyzések:(R)?Salsolinol (SAL), a dopamine (DA)?related tetrahydroisoquinoline, has been found in extracts of the neuro?intermediate lobes (NIL) of pituitary glands and in the median eminence of the hypothalamus obtained from intact male rats and from ovariectomized and lactating female rats. Moreover, analysis of SAL concentrations in NIL revealed parallel increases with plasma prolactin (PRL) in lactating rats exposed to a brief (10 min) suckling stimulus after 4?h separation. SAL is sufficiently potent in vivo to account for the massive discharge of PRL that occurs after physiological stimuli (i.e. suckling). At the same time, it was without effect on the secretion of other pituitary hormones. It has been also shown that another isoquinoline derivative, 1?methyldihydroisoquinoline (1MeDIQ), which is a structural analogue of SAL, can dose?dependently inhibit the in?vivo PRL?releasing effect of SAL. Moreover, 1MeDIQ can inhibit the elevation of plasma PRL induced by physiological stimuli, for example suckling, or in different stressful situations also. 1MeDIQ also has a psycho?stimulant action, which is fairly similar to the effect of amphetamine, i.e. it induces an increase in plasma catecholamine concentrations. It is clear from these data that this newly discovered endogenous compound could be involved in regulation of pituitary PRL secretion. It has also been observed that SAL is present in peripheral, sympathetically innervated organs, for example the atrium, spleen, liver, ovaries, vas deferens, and salivary gland. Furthermore, SAL treatment of rats results in dose?dependent and time?dependent depletion of the DA content of the organs listed above without having any effect on the concentration of norepinephrine. More importantly, this effect of SAL can be completely prevented by amphetamine and by 1MeDIQ pretreatment. It is clear there is a mutual interaction between SAL, 1MeDIQ, and amphetamine or alcohol, not only on PRL release; their interaction with catecholamine "synthesis/metabolism" of sympathetic nerve terminals is also obvious.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Reproductive Medicine and Biology 10 : 3 (2011), p. 143-151. -
További szerzők:Bodnár Ibolya Daniel, Galit Tóth E. Béla (1960-) (orvos) Vecsernyés Miklós (1959-) (gyógyszertechnológus, endokrinológus) Nagy György M.
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