Találati lista | Tudóstér

001-es BibID:	BIBFORM030660
Első szerző:	Radnai Balázs
Cím:	Salsolinol induces a decrease in cyclic AMP at the median eminence and an increase at the adenohypophysis in lactating rats / Balázs Radnai, Zoltán Kandár, Anikó Somogyvári-Vigh, Zsuzsanna Mergl, Márk Oláh, Ferenc Fülöp, Miklós Vecsernyés, György M. Nagy
Dátum:	2005
ISSN:	0361-9230
Megjegyzések:	Investigating the cellular events in the pituitary gland, the intracellular cyclic AMP (cAMP) of the median eminence (ME), neuro-intermediate lobe (NIL) and the anterior lobe (AL) have been measured following 15-min of intravenous injection of salsolinol (SAL). Parallel to the elevation of plasma prolactin (PRL), SAL induced a significant decrease of cAMP concentration in the ME. In contrast, SAL injection resulted in a significant increase of cAMP at the level of the AL. Changes in cAMP of the NIL as well as in the plasma level of vasopressin (VP) could not be detected. The observed changes in the level of cAMP following the acute treatment of SAL in the ME and the AL seems to be related to interacting neuroendocrine signals delivered from the ME to the AL through the long portal vessels to release PRL.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban pituitary gland prolactin tetrahydroisoquinoline vasopressin egyetemen (Magyarországon) készült közlemény
Megjelenés:	Brain Research Bulletin 65 : 2 (2005), p. 105-110. -
További szerzők:	Kandár Zoltán Somogyvári-Vigh Anikó Mergl Zsuzsanna Oláh Márk Fülöp Ferenc (Szeged) Vecsernyés Miklós (1959-) (gyógyszertechnológus, endokrinológus) Nagy György M.
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:

001-es BibID:	BIBFORM031973
Első szerző:	Tóth E. Béla (orvos)
Cím:	Salsolinol is putative endogenous Neuro-intermediate lobe prolactin-releasing factor / Tóth B. E., Homicskó K., Radnai B., Maruyama W., DeMaria J. E., Vecsernyés M., Fekete M. I. K., Fülöp F., Naoi M., Freeman M. E., Nagy G. M.
Dátum:	2001
ISSN:	0953-8194
Megjegyzések:	The isolation and identification of a prolactin-releasing factor (PRF) from the neuro-intermediate lobe of the pituitary gland has been pursued for over a decade. Using high-pressure liquid chromatography with electrochemical detection (HPLC-ECD) and gas chromatography/mass spectrometry (GC/MS) (R)-salsolinol (SAL) (a dopamine-related stereo-specific tetrahydroisoquinoline) was found to be present in neuro-intermediate lobe as well as median eminence extracts of male, intact-, and ovariectomized female rats. Moreover, analysis of SAL concentrations in neuro-intermediate lobe revealed parallel increases with plasma prolactin in lactating rats exposed to a brief (10 min) suckling stimulus following 4-h separation. SAL appears to be a selective and potent stimulator of prolactin secretion in vivo and it was without effect on the secretion of other pituitary hormones. We have also found that SAL can elevate prolactin release, although to a lesser extent, in pituitary cell cultures as well as in hypophysectomized rats bearing anterior lobe transplants under the kidney capsule. Lack of interference of SAL with [3H]-spiperone binding to AP homogenates indicates that SAL does not act at the dopamine D2 receptor. Moreover, [3H]-SAL binds specifically to homogenate of AL as well as neuro-intermediate lobe obtained from lactating rats. Taken together, our data clearly suggest that SAL is synthesized in situ and this compound can play a role in the regulation of pituitary prolactin secretion.
Tárgyszavak:	Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Journal Of Neuroendocrinology 13 : 12 (2001), p. 1042-1050. -
További szerzők:	Homicskó Krisztián Gy. Radnai Balázs Maruyama W. DeMaria, Jamie E. Vecsernyés Miklós (1959-) (gyógyszertechnológus, endokrinológus) Fekete I. K. Márton Fülöp Ferenc Naoi, M. Freeman, Marc E. Nagy György M.
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
Borító:
Saját polcon: