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001-es BibID:	BIBFORM030655
Első szerző:	Sarnyai Zoltán
Cím:	Oxytocin modulates behavioural adaptation to repeated treatment with cocaine in rats / Z. Sarnyai, Éva Bíró, E. Babarczy, M. Vecsernyés, F. Laczi, G. Szabó, Márta Kriván, G. L. Kovács, G. Telegdy
Dátum:	1992
ISSN:	0028-3908
Megjegyzések:	Behavioural adaptation to and the effects of the neurohypophyseal peptide, oxytocin, on repeated treatment with cocaine were investigated in rats. The content of immunoreactive oxytocin in the plasma, hypothalamus and different limbic structures in the brain were also studied after treatment with cocaine, identical to that used in the behavioural experiment. Repeated administration of cocaine (7.5 mg/kg, s.c.) produced a behavioural tolerance to the stereotyped sniffing-inducing effect of the challenge doses (1.875, 3.75 and 7.5 mg/kg, s.c.) of cocaine on the fifth day, which was demonstrated by parallel shifting of the dose-response and time-effect curves of the test doses of cocaine. The development of tolerance was inhibited by pretreatment with oxytocin (0.05 micrograms, (s.c.), administered before each daily injection of cocaine. A smaller dose of oxytocin (0.005 micrograms, s.c.) had no effect in this model. A decreased amount of immunoreactive oxytocin was detected in the plasma, in the hypothalamus and in the hippocampus, after repeated treatment with cocaine. Replacement of oxytocin by local injection (100 pg) into the ventral hippocampus, before each daily administration of cocaine, prevented the development of tolerance to cocaine. These results suggest that endogenous oxytocin, localized in limbic-forebrain areas, may have an important regulatory role in the development of behavioural changes induced by the repeated administration of cocaine.
Tárgyszavak:	Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban cocaine tolerance oxytocin limbic-forebrain structures egyetemen (Magyarországon) készült közlemény
Megjelenés:	Neuropharmacology 31 : 6 (1992), p. 593-598. -
További szerzők:	Bíró Éva Babarczy Eszter (1966-) Vecsernyés Miklós (1959-) (gyógyszertechnológus, endokrinológus) Laczi Ferenc (Szeged) Szabó G. Kriván Márta Kovács Gábor L. (Szeged) Telegdy Gyula (Szeged)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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