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001-es BibID:	BIBFORM099847
035-os BibID:	(WOS)000743412100002 (Scopus)85123091562
Első szerző:	Singh, Parvind (PhD hallgató)
Cím:	Age-dependent frequency of unconventional T cells in a healthy adult Caucasian population : a combinational study of invariant natural killer T cells, [gamma][delta] T cells, and mucosa-associated invariant T cells / Singh Parvind, Szaraz-Szeles Marianna, Mezei Zoltan, Barath Sandor, Hevessy Zsuzsanna
Dátum:	2022
ISSN:	2509-2715 2509-2723
Megjegyzések:	Unconventional T cells show distinct and unique features during antigen recognition as well as other immune responses. Their decrease in frequency is associated with various autoimmune disorders, allergy, inflammation, and cancer. The landscape frequency of the unconventional T cells altogether (iNKT, gamma delta T, and MAIT) is largely unestablished leading to various challenges affecting diagnosis and research in this field. In this study, we have established the age group-wise frequency of iNKT, gamma delta T, and MAIT cells altogether on a total of 203 healthy adult samples of the Caucasian population. The results revealed that iNKT cells were 0.095%, gamma delta T cells were 2.175%, and MAIT cells were 2.99% of the total T cell population. gamma delta and MAIT cell frequency is higher in younger age groups than elderly; however, there is no statistically significant difference in the frequency of iNKT cells. Furthermore, gamma delta and MAIT cells were negatively correlating with age, supporting immunosenescence, unlike iNKT cells. Our finding could be used for further age-wise investigation of various pathological conditions such as cancer and their prognosis, autoimmune diseases and their pathogenicity.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Unconventional T cells iNKT cells gamma delta T cells MAIT cells frequency reference range age dependent
Megjelenés:	GeroScience. - 44 : 4 (2022), p. 2047-2060. -
További szerzők:	Széles Mariann Mezei Zoltán András (1980-) (orvos) Baráth Sándor (1977-) (biológus) Hevessy Zsuzsanna (1966-) (laboratóriumi szakorvos)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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