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001-es BibID:	BIBFORM055597
Első szerző:	Erdődi Balázs (szülész-nőgyógyász szakorvosjelölt)
Cím:	Does HE4 improve the diagnosis of pelvic masses in non-experienced examiners? / B. Erdődi, Z. Krasznai, L. Ördög, E. Maka, H. Balla, Z. Tóth, A. Jakab
Dátum:	2014
ISSN:	0960-7692
Megjegyzések:	Objectives: To determine the additive diagnostic value of HE4 tumor marker to in the IOTA's three step strategy for managing adnexal masses focusing on non-experienced examiners.Methods: Imaging properties of ovarian masses were evaluated preoperatively using the IOTA terms and definitions. Two groups of patients were made:1: premenopausal (PEM); 2: postmenopausal (POM). In both groups adnexal masses were characterised by the ♭easy descriptors' and in cases where these were not applicable the IOTA Simple rules had been used. US results then were matched with the preoperative CA125 and HE4 tumor marker levels and histological findings. Results: Overall285patientswithovarianmasseswererecruitedin the analysis (average: 42.0 yrs; range: 12?82 yrs). In the PEM group we had 199 cases (69.82%; range: 12?53 yrs; average: 33.12 yrs),in the POM group 86 cases were involved (30.18%; range: 48?82 yrs; average: 63.09 yrs). In the PEM group 104 patients had the diagnosis based on easy descriptors (52.26%) while 76 patient of the rest fulfilled the requirements for the simple rules. In the POM group 48 patients (55.81%) were diagnosed by the easy descriptors and 36 (41.86%) of the rest could also be scanned according to the M- and B-rules and only 2 (2.33%) patients called for pattern recognition. If CA125 determination was changed to HE4 evaluation in case of easy descriptors the total diagnostic accuracy increased in the PEM group (PPV: 1.00; NPV: 0.98; sensitivity: 33.33%; specificity 100%), similar increase in POM group was not detected. 23 malignant cases were found in the PEM group, 2 of them were diagnosed by easy descriptors while 16 of them were diagnosed by the simple rules. In the POM group 47 malignancies were detected, 32 of them were diagnosed by the easy descriptors additional 12 by M-rules. Conclusions: IOTA easy descriptors and simple rules can be used effectively for non-experienced examiners in more than 90% of the cases. This can be increased by HE4 evaluation especially in premenopausal patients.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idézhető absztrakt gynecology ultrasound ovarian mass IOTA
Megjelenés:	Ultrasound in Obstetrics & Gynecology. - 44 : S1 (2014), p. 5. -
További szerzők:	Krasznai Zoárd Tibor (1973-) (szülész-nőgyógyász, gyermeknőgyógyász) Ördög Lilla Maka Eszter (1988-) (szülész-nőgyógyász rezidens) Balla Heidi Tóth Zoltán (1948-) (szülész-nőgyógyász, humángenetikus) Jakab Attila (1964-) (szülész-nőgyógyász, endokrinológus)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM055604
Első szerző:	Erdődi Balázs (szülész-nőgyógyász szakorvosjelölt)
Cím:	The additive value of HE4 novel tumor marker to the IOTA simple rules in the management of ovarian masses / B. Erdődi, Z. Krasznai, E. Maka, L. Ördög, H. Balla, Z. Tóth, A. Jakab
Dátum:	2013
ISSN:	0960-7692
Megjegyzések:	Objectives: To determine the additive diagnostic value of HE4 tumor marker to the IOTA simple ultrasonographic (US) morpho- logic scoring system in the management of ovarian masses. Methods: Imaging properties of ovarian masses were evaluated preoperatively using the IOTA M and B rules. According to the US findings and the IOTA simple rules three groups were made: 1. B group: only B rules were applicable, 2. M group: only M rules were applicable, 3. E group: both M and B rules were applicable, expert's opinion needed. US results were matched with the preoperative CA125 and HE4 levels and the histological findings.Results: patients with ovarian masses were involved in the analysis (average: 42.10yrs, 13-83yrs). Among the 107 cases (50.95%, average: 38.39yrs, 13-78yrs) of the B group two turned to be malignant (1.87%). HE4 was elevated in 8, CA125 in 66, both of them in 3 cases. 74 patients fulfilled the requirements for M-rules (35.24%, average: 49.43yrs, 15-83yrs,), 42 proved to be malignant (56.76%). HE4 was increased in 34, CA125 in 55, both of them in 31 cases. E group was formed by 29 cases (13.81%, range: 16-81yrs, average: 37.10yrs) of which 5 showed malignancy (17.24%). Where the IOTA simple rules were applied US alone had a a sensitivity of 48.84% and a specificity of 76.64% which increased to 93.40% adding HE4 evaluation to the diagnostic algorithm. PPV also increased from 0.56 to 0.79 in those cases where HE4 was used together with US. Pattern recognition showed a NPV of 0.92 and a PPV of 0.26 which was raised to 1.0 as HE4 was used additionally. Specicity of combining pattern recognition and HE4 evaluation proved to be 100% in this study.Conclusions: IOTA simple rules can be used effectively to discrim- inate between benign and malignant ovarian masses in more than 85% of the cases. Masses with complex morphology often need pattern recognition which can call for other methods increasing both the predictive values and specificity of the method. HE4 can be used effectively to increase the specificity of the diagnostic ability of US.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idézhető absztrakt gynecology ultrasound ovarian pathology IOTA
Megjelenés:	Ultrasound in Obstetrics & Gynecology. - 42 : S1 (2013), p. 27. -
További szerzők:	Krasznai Zoárd Tibor (1973-) (szülész-nőgyógyász, gyermeknőgyógyász) Maka Eszter (1988-) (szülész-nőgyógyász rezidens) Ördög Lilla Balla Heidi Tóth Zoltán (1948-) (szülész-nőgyógyász, humángenetikus) Jakab Attila (1964-) (szülész-nőgyógyász, endokrinológus)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM053321
Első szerző:	Erdődi Balázs (szülész-nőgyógyász szakorvosjelölt)
Cím:	A HE4 tumormarker UH diagnosztika mellett betöltött additív szerepe a petefészek képletek differenciál diagnosztikájában / Erdődi Balázs, Krasznai Zoárd, Ördög Lilla, Tóth Zoltán, Balla Heidi, Maka Eszter, Jakab Attila
Dátum:	2014
Tárgyszavak:	Orvostudományok Klinikai orvostudományok poszter súlypercentilis HE4 tumormarker
Megjelenés:	Magyar Nőorvosok Lapja. - Különszám (2014), p. 100. -
További szerzők:	Krasznai Zoárd Tibor (1973-) (szülész-nőgyógyász, gyermeknőgyógyász) Ördög Lilla Tóth Zoltán (1948-) (szülész-nőgyógyász, humángenetikus) Balla Heidi Maka Eszter (1988-) (szülész-nőgyógyász rezidens) Jakab Attila (1964-) (szülész-nőgyógyász, endokrinológus)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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