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001-es BibID:	BIBFORM123331
035-os BibID:	(scopus)85202639288
Első szerző:	Csikos Csaba (orvos)
Cím:	Predicting Complete Cytoreduction with Preoperative [18F]FDG PET/CT in Patients with Ovarian Cancer : a Systematic Review and Meta-Analysis / Csikos Csaba, Czina Péter, Molnár Szabolcs, Kovács Anna, Garai Ildikó, Krasznai Zoárd
Dátum:	2024
ISSN:	2075-4418
Megjegyzések:	The cornerstone of ovarian cancer treatment is complete surgical cytoreduction. The gold-standard option in the absence of extra-abdominal metastases and intra-abdominal inoperable circumstances is primary cytoreductive surgery (CRS). However, achieving complete cytoreduction is challenging, and only possible in a selected patient population. Preoperative imaging modalities such as [18F]FDG PET/CT could be useful in patient selection for cytoreductive surgery. In our sys- tematic review and meta-analysis, we aimed to evaluate the role of preoperative [18F]FDG PET/CT in predicting complete cytoreduction in primary and secondary debulking surgeries. Publications were pooled from two databases (PubMed, Mendeley) with predefined keywords "(ovarian cancer) AND (FDG OR PET) AND (cytoreductive surgery)". The quality of the included studies was assessed with the Prediction model Risk Of Bias Assessment Tool (PROBAST). During statistical analysis, MetaDiSc 1.4 software and the DerSimonian?Laird method (random effects models) were used. Primary and secondary cytoreductive surgeries were evaluated. Pooled sensitivities, specificities, positive predictive values (PPVs), and negative predictive values (NPVs) were calculated and statistically ana- lyzed. Results were presented in forest plot diagrams and summary receiver operating characteristic (SROC) curves. Overall, eight publications were included in our meta-analysis. Four publications presented results of primary, three presented results of secondary cytoreductions, and two presented data related to both primary and secondary surgery. Pooled sensitivities, specificities, and positive and negative predictive values were the following: in the case of primary surgeries: 0.65 (95% CI 0.60?0.71), 0.73 (95% CI 0.66?0.80), 0.82 (95% CI 0.77?0.87), 0.52 (95% CI 0.46?0.59); and in the case of secondary surgeries: 0.91 (95% CI 0.84?0.95), 0.48 (95% CI 0.30?0.67), 0.88 (95% CI 0.81?0.93), 0.56 (95% CI 0.35?0.75), respectively. The PPVs of [18F]FDG PET/CT proved to be higher in cases of secondary debulking surgeries; therefore, it can be a valuable predictor of complete successful secondary cytoreduction.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk ovarian cancer cytoreductive surgery preoperative [18F]FDG PET/CT complete debulking prediction
Megjelenés:	Diagnostics. - 14 : 16 (2024), p. 1-14.-
További szerzők:	Czina Péter Molnár Szabolcs (1987-) (szülész-nőgyógyász szakorvos) Kovács Anna Rebeka (1993-) (általános orvos) Garai Ildikó (1966-) (radiológus) Krasznai Zoárd Tibor (1973-) (szülész-nőgyógyász, gyermeknőgyógyász)
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001-es BibID:	BIBFORM090672
035-os BibID:	(cikkazonosító)144 (WoS)000610107000001 (Scopus)85108696869
Első szerző:	Molnár Szabolcs (szülész-nőgyógyász szakorvos)
Cím:	The Prognostic Relevance of Poly (ADP-Ribose) Polymerase Expression in Ovarian Cancer Tissue of Wild Type and BRCA-Mutation Carrier Patients / Molnár Szabolcs, Vida Beáta, Beke Lívia, Méhes Gábor, Póka Róbert
Dátum:	2021
ISSN:	2075-4418
Megjegyzések:	(1) Background: The mechanism of platinum resistance in ovarian cancer is not fully clar? ified, but the properly functioning DNA repair mechanism can counteract the effect of conventional anticancer treatment. The objective of our study was to evaluate the expression of an important DNA repair enzyme, the Poly (ADP?Ribose) Polymerase (PARP) expression in epithelial ovarian cancer (EOC) tissues depending on BRCA status and to assess its relationship with platinum re? sistance. (2) Methods: Immunostaining to highlight PARP protein expression was performed using a rabbit polyclonal anti?PARP antibody. The intensity and distribution of immunostaining were as? sessed by light. Somatic BRCA1 or BRCA2 mutation carriers were identified with bidirectional se? quencing of DNA from archived tumor tissue, if the test could not be performed due to technical reasons from tumor cells, the sequencing was done from peripheral blood cells to identify germline mutation carriers. The median progression?free survival (PFS) was generated for each semiquanti? tative group of PARP expression among chemotherapy?naive cases at the time of PARP immuno? histochemistry. (3) Results: In the overall population, negative PARP immunohistochemistry pre? dicted significant PFS (20.1 vs. 11.9 months, p = 0.001) and OS (49 vs. 114 months, p = 0.014) benefit. Genotype?stratified subgroup analysis in BRCA?negative cases confirmed the role of PARP positiv? ity indicating an unfavorable prognosis in the entire population (relapsed 73.91% vs. 92%; OR: 4.06; p = 0.04). In the cases of the subgroup carrying the BRCA mutation, the presence of PARP expression was not associated with less favorable relapse rates, but with marginal significance for overall sur? vival predicted a lower chance of survival (OS more than 32 months 72.73% vs. 35%; OR: 0.2; p = 0.05). (4) Conclusion: The BRCA wild type patients with strong expression of PARP enzymes before the first set of chemotherapy have a poor prognosis.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk ovarian cancer BRCA mutation PARP expression gynecological oncology platinum? based chemotherapy progression?free survival
Megjelenés:	Diagnostics. - 11 : 1 (2021), p. 1-10. -
További szerzők:	Vida Beáta (1994-) (szülészet-nőgyógyászat) Beke Lívia Méhes Gábor (1966-) (patológus) Póka Róbert (1960-) (szülész-nőgyógyász, klinikai onkológus)
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