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001-es BibID:BIBFORM066474
Első szerző:Marics Balázs (okleveles táplálkozástudományi szakember, dietetikus)
Cím:Diet-induced obesity enhances TRPV1-mediated neurovascular reactions in the dura mater / Marics B., Peitl B., Pázmándi K., Bácsi A., Németh J., Oszlács O., Jancsó G., Dux M.
Dátum:2017
ISSN:0017-8748
Megjegyzések:Objective: Exploring the pathophysiological changes in transient receptor potential vanilloid 1 (TRPV1) receptor of the trigeminovascular system in high-fat, high-sucrose (HFHS) diet-inducedobesity of experimental animals.Background: Clinical and experimental observations suggest a link between obesity and migraine. Accumulating evidence indicates that metabolic and immunological alterations associated with obesity may potentially modulate trigeminovascular functions. A possible target for obesity-induced pathophysiological changes is the TRPV1/capsaicin receptor which is implicated in the pathomechanism of headaches in a complex way.Methods: Male Sprague-Dawley rats were fed a regular (n = 25) or HFHS diet (n = 26) for 20 weeks. At the end of the dietary period, body weight of the animals was normally distributed in both groups and it was significantly higher in animals on HFHS diet. Therefore, experimental groups were regarded as control and HFHS diet-induced obese groups. Capsaicin-induced changes in meningeal blood flow and release of calcitonin gene-related peptide (CGRP) from dural trigeminal afferents were measured in control and obese rats. The distribution of TRPV1- and CGRP-immunoreactive meningeal sensory nerves was also compared in whole mount preparations of the dura mater. Metabolic parameters of the animals were assessed by examining glucose and insulin homeostasis as well as plasma cytokine concentrations.Results: HFHS diet was accompanied by reduced food consumption and greater fluid and energy intakes in addition to increased body weight of the animals. HFHS diet increased fasting blood glucose and insulin concentrations as well as levels of circulating proinflammatory cytokines interleukin-1? and interleukin-6. In obese animals, dural application of the archetypal TRPV1 agonist capsaicin resulted in significantly augmented vasodilatory and vasoconstrictor responses as compared to controls. Diet-induced obesity was also associated with enhanced basal and capsaicin- induced CGRP release from meningeal afferents ex vivo. Except for minor morphological changes, the distribution of dural TRPV1- and CGRP-immunoreactive afferents was similar in control and obese animals.Conclusions: Our results suggest that obesity induced by long-term HFHS diet results in sensitization of the trigeminovascular system. Changes in TRPV1-mediated vascular reactions and CGRP release are pathophysiological alterations that may be of relevance to the enhanced headache susceptibility of obese individuals.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
headache
obesity
transient receptor potential vanilloid 1
calcitonin gene-related peptide
meningeal blood flow
trigeminal nociception
Megjelenés:Headache 57 : 3 (2017), p. 441-454. -
További szerzők:Peitl Barna (1972-) (orvos, farmakológus) Pázmándi Kitti Linda (1984-) (molekuláris biológus, immunológus) Bácsi Attila (1967-) (immunológus) Németh József (1954-) (vegyész, analitikus) Oszlács Orsolya Jancsó Gábor Dux Mária
Pályázati támogatás:OTKA K-101873
OTKA
OTKA K119597
OTKA
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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2.

001-es BibID:BIBFORM066140
035-os BibID:(WOS)000401026600010 (Scopus)85019141123
Első szerző:Marics Balázs (okleveles táplálkozástudományi szakember, dietetikus)
Cím:Diet-induced obesity alters dural CGRP release and potentiates TRPA1-mediated trigeminovascular responses / Balázs Marics, Barna Peitl, Angelika Varga, Kitti Pázmándi, Attila Bácsi, József Németh, Zoltán Szilvássy, Gábor Jancsó, Mária Dux
Dátum:2017
ISSN:0333-1024
Megjegyzések:Background: Clinical studies suggest a link between obesity and the primary headache disorder migraine. In our studywe aimed to reveal the effect of obesity on meningeal nociceptor function in rats receiving a high-fat, high-sucrose diet.Methods: Transient receptor potential ankyrin 1 (TRPA1) receptor activation-induced changes in meningeal blood flow,release of calcitonin gene-related peptide (CGRP) from trigeminal afferents and TRPA1 protein expression in thetrigeminal ganglia were measured in control and obese rats. Metabolic parameters of the animals were assessed bymeasuring glucose and insulin homeostasis as well as plasma cytokine concentrations.Results: The present experiments revealed an enhanced basal and TRPA1 receptor agonist-induced CGRP release frommeningeal afferents of obese insulin-resistant rats and an attenuated CGRP release to potassium chloride. Obesity wasalso associated with an augmented vasodilatation in meningeal arteries after dural application of the TRPA1 agonistacrolein, a reduction in TRPA1 protein expression in the trigeminal ganglia and elevations in circulating proinflammatorycytokines IL-1b and IL-6 in addition to increased fasting blood glucose and insulin concentrations.Conclusions: Our results suggest trigeminal sensitisation as a mechanism for enhanced headache susceptibility in obeseindividuals after chemical exposure of trigeminal nociceptors.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Obesity
calcitonin gene-related peptide
sensory neuron
laser Doppler flowmetry
headache
transient receptor potential ankyrin 1
Megjelenés:Cephalalgia. - 37 : 6 (2017), p. 581-591. -
További szerzők:Peitl Barna (1972-) (orvos, farmakológus) Varga Angelika (1977-) (biológus) Pázmándi Kitti Linda (1984-) (molekuláris biológus, immunológus) Bácsi Attila (1967-) (immunológus) Németh József (1954-) (vegyész, analitikus) Szilvássy Zoltán (1957-) (belgyógyász, farmakológus, klinikai farmakológus) Jancsó Gábor Dux Mária
Pályázati támogatás:K-101873
OTKA
4.1.2.E-13/1/KONV-2013-0010
TÁMOP
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
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