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001-es BibID:	BIBFORM078694
035-os BibID:	(cikkazonosító)e01245-18 (WoS)000460314300008 (Scopus)85059795594 (PMID)30622192 (PMCID)PMC6325243
Első szerző:	Palm, Angelica A.
Cím:	Low Postseroconversion CD4+ T-cell Level Is Associated with Faster Disease Progression and Higher Viral Evolutionary Rate in HIV-2 Infection / Angelica A. Palm, Philippe Lemey, Marianne Jansson, Fredrik Månsson, Anders Kvist, Zsófia Szojka, Antonio Biague, Zacharias José da Silva, Sarah L. Rowland-Jones, Hans Norrgren, Joakim Esbjörnsson, Patrik Medstrand, SWEGUB CORE Group
Dátum:	2019
ISSN:	2150-7511
Megjegyzések:	A positive correlation between virus evolutionary rate and disease pro- gression has been shown for human immunodeficiency virus type 1 (HIV-1) infec- tion. Much less is known about HIV-2, the second causative agent of AIDS. We analyzed 528 HIV-2 env V1-C3 sequences generated from longitudinal plasma samples that were collected from 16 study participants during a median observa- tion time of 7.9 years (interquartile range [IQR], 5.2 to 14.0 years). Study partici- pants were classified as faster or slower disease progressors based on longitudi- nal CD4 T-cell data. The HIV-2 evolutionary rate was significantly associated with CD4 T-cell levels and was almost twice as high among the faster progres- sors as among the slower progressors. Higher evolutionary rates were accounted for by both synonymous and nonsynonymous nucleotide substitutions. More- over, slow disease progression was associated with stronger positive selection on HIV-2/SIVsm (simian immunodeficiency virus infecting sooty mangabey) surface- exposed conserved residues. This study demonstrated a number of previously unknown characteristics linking HIV-2 disease progression with virus evolution. Some of these findings distinguish HIV-2 from HIV-1 and may contribute to the understanding of differences in pathogenesis.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	mBio. - 10 : 1 (2019), p. 1-14. -
További szerzők:	Lemey, Philippe Jansson, Marianne Månsson, Fredrik Kvist, Anders Szojka Zsófia (1991-) (molekuláris biológus) Biague, Antonio da Silva, Zacharias Rowland-Jones, Sarah L. Norrgren, Hans Esbjörnsson, Joakim Medstrand, Patrik SWEGUB CORE Group
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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