Összesen 2 találat.


001-es BibID:BIBFORM078695
035-os BibID:(WoS)000482346000010 (Scopus)85065641534
Első szerző:Karlsson, Ingrid
Cím:Cross-Reactive Antibodies With the Capacity to Mediate HIV-1 Envelope Glycoprotein-Targeted Antibody-Dependent Cellular Cytotoxicity Identified in HIV-2-Infected Individuals / Ingrid Karlsson, Jeanette Linnea Tingstedt, Gülşen Özkaya Şahin, Mikkel Hansen, Zsofia Szojka, Marcus Buggert, Antonio Biague, Zacharias da Silva, Fredrik Månsson, Joakim Esbjörnsson, Hans Norrgren, Patrik Medstrand, Anders Fomsgaard, Marianne Jansson, Sweden-Guinea-Bissau Cohort Research Group
Megjegyzések:Disease progression of human immunodeficiency virus type 1 (HIV-1) is delayed by HIV type 2 (HIV-2) in individuals with dual HIV-1/HIV-2 infection. The protective mechanisms, however, are still to be revealed. In the current study we examined type-specific and cross-reactive antibody-dependent cellular cytotoxicity (ADCC) in HIV-1 and HIV-2 monoinfection or dual infection. Of note, intertype cross-reactive antibodies that mediated HIV-1 envelope glycoprotein (Env)-targeted ADCC were frequently identified in HIV-2-infected individuals. Furthermore, the magnitude of HIV-1 cross-reactive ADCC activity during HIV-2 infections depended on the HIV-1 Env origin and was associated with the duration of infection. These results suggest that preexisting antibodies against HIV-2, which mediate intertype ADCC, might contribute to control of HIV-1 during dual infection.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Cross-Reactive Antibodies
HIV-2 infection
HIV-1 Envelope Glycoprotein
Megjelenés:Journal Of Infectious Diseases. - 219 : 11 (2019), p. 1749-1754. -
További szerzők:Tingstedt, Jeanette Linnea Şahin, Gülşen Özkaya Hansen, Mikkel Szojka Zsófia (1991-) (molekuláris biológus) Buggert, Marcus Biague, Antonio da Silva, Zacharias Månsson, Fredrik Esbjörnsson, Joakim Norrgren, Hans Medstrand, Patrik Fomsgaard, Anders Jansson, Marianne Sweden-Guinea-Bissau Cohort Research Group
Internet cím:Szerző által megadott URL
Intézményi repozitóriumban (DEA) tárolt változat


001-es BibID:BIBFORM078694
035-os BibID:(cikkazonosító)e01245-18 (WoS)000460314300008 (Scopus)85059795594 (PMID)30622192 (PMCID)PMC6325243
Első szerző:Palm, Angelica A.
Cím:Low Postseroconversion CD4+ T-cell Level Is Associated with Faster Disease Progression and Higher Viral Evolutionary Rate in HIV-2 Infection / Angelica A. Palm, Philippe Lemey, Marianne Jansson, Fredrik Månsson, Anders Kvist, Zsófia Szojka, Antonio Biague, Zacharias José da Silva, Sarah L. Rowland-Jones, Hans Norrgren, Joakim Esbjörnsson, Patrik Medstrand, SWEGUB CORE Group
Megjegyzések:A positive correlation between virus evolutionary rate and disease pro- gression has been shown for human immunodeficiency virus type 1 (HIV-1) infec- tion. Much less is known about HIV-2, the second causative agent of AIDS. We analyzed 528 HIV-2 env V1-C3 sequences generated from longitudinal plasma samples that were collected from 16 study participants during a median observa- tion time of 7.9 years (interquartile range [IQR], 5.2 to 14.0 years). Study partici- pants were classified as faster or slower disease progressors based on longitudi- nal CD4 T-cell data. The HIV-2 evolutionary rate was significantly associated with CD4 T-cell levels and was almost twice as high among the faster progres- sors as among the slower progressors. Higher evolutionary rates were accounted for by both synonymous and nonsynonymous nucleotide substitutions. More- over, slow disease progression was associated with stronger positive selection on HIV-2/SIVsm (simian immunodeficiency virus infecting sooty mangabey) surface- exposed conserved residues. This study demonstrated a number of previously unknown characteristics linking HIV-2 disease progression with virus evolution. Some of these findings distinguish HIV-2 from HIV-1 and may contribute to the understanding of differences in pathogenesis.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:mBio. - 10 : 1 (2019), p. 1-14. -
További szerzők:Lemey, Philippe Jansson, Marianne Månsson, Fredrik Kvist, Anders Szojka Zsófia (1991-) (molekuláris biológus) Biague, Antonio da Silva, Zacharias Rowland-Jones, Sarah L. Norrgren, Hans Esbjörnsson, Joakim Medstrand, Patrik SWEGUB CORE Group
Internet cím:Szerző által megadott URL
Intézményi repozitóriumban (DEA) tárolt változat
Rekordok letöltése1