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001-es BibID:	BIBFORM078695
035-os BibID:	(WoS)000482346000010 (Scopus)85065641534
Első szerző:	Karlsson, Ingrid
Cím:	Cross-Reactive Antibodies With the Capacity to Mediate HIV-1 Envelope Glycoprotein-Targeted Antibody-Dependent Cellular Cytotoxicity Identified in HIV-2-Infected Individuals / Ingrid Karlsson, Jeanette Linnea Tingstedt, Gülşen Özkaya Şahin, Mikkel Hansen, Zsofia Szojka, Marcus Buggert, Antonio Biague, Zacharias da Silva, Fredrik Månsson, Joakim Esbjörnsson, Hans Norrgren, Patrik Medstrand, Anders Fomsgaard, Marianne Jansson, Sweden-Guinea-Bissau Cohort Research Group
Dátum:	2019
ISSN:	0022-1899
Megjegyzések:	Disease progression of human immunodeficiency virus type 1 (HIV-1) is delayed by HIV type 2 (HIV-2) in individuals with dual HIV-1/HIV-2 infection. The protective mechanisms, however, are still to be revealed. In the current study we examined type-specific and cross-reactive antibody-dependent cellular cytotoxicity (ADCC) in HIV-1 and HIV-2 monoinfection or dual infection. Of note, intertype cross-reactive antibodies that mediated HIV-1 envelope glycoprotein (Env)-targeted ADCC were frequently identified in HIV-2-infected individuals. Furthermore, the magnitude of HIV-1 cross-reactive ADCC activity during HIV-2 infections depended on the HIV-1 Env origin and was associated with the duration of infection. These results suggest that preexisting antibodies against HIV-2, which mediate intertype ADCC, might contribute to control of HIV-1 during dual infection.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Cross-Reactive Antibodies HIV-2 infection HIV-1 Envelope Glycoprotein ADCC
Megjelenés:	Journal Of Infectious Diseases. - 219 : 11 (2019), p. 1749-1754. -
További szerzők:	Tingstedt, Jeanette Linnea Şahin, Gülşen Özkaya Hansen, Mikkel Szojka Zsófia (1991-) (molekuláris biológus) Buggert, Marcus Biague, Antonio da Silva, Zacharias Månsson, Fredrik Esbjörnsson, Joakim Norrgren, Hans Medstrand, Patrik Fomsgaard, Anders Jansson, Marianne Sweden-Guinea-Bissau Cohort Research Group
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