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001-es BibID:BIBFORM073934
Első szerző:Nagy Tamás Milán (vegyész, nmr)
Cím:Boosting the NMR assignment of small to medium-sized molecules with different edited variants of HSQC-CLIP-COSY experiment / Tamás Milán Nagy, Tamás Gyöngyösi, Sándor Boros, Burkhard Luy, Katalin E. Kövér
Megjegyzések:The recently introduced CLIP-COSY[1] experiment providing homonuclear correlation spectrum with high quality clean in-phase multiplets expedites the assignment of scalar coupled proton spin network and so, the structure elucidation of small and medium-sized molecules. However, the resolution of COSY spectra is limited by the inherently small chemical shift dispersion of proton resonances.To utilize the resolving power of heteronuclei offered by their superior chemical shift range, we have devised an HSQC-variant of the CLIP-COSY experiment.[2] Herein, we demonstrate that the performance of the original HSQC-CLIP-COSY experiment can be further boosted with incorporation of heteronuclear spin echo block(s), allowing editing of X-nuclei according to even or odd multiplicity and/or editing of direct HSQC correlations vs. CLIP-COSY peaks.The different phases imposed on the direct and relay peaks facilitate to track out the connectivity network of protonated carbons, making the simultaneous assignment of 1H and 13C resonances of medium-sized molecules possible from a single spectrum.Besides, utilization of the non-uniform sampling (NUS) scheme, allowing to cut down the number of indirect increments without sacrificing the resolution will also be presented.
Tárgyszavak:Természettudományok Kémiai tudományok előadáskivonat
edited HSQC
automated asssignment
Megjelenés:59th Experimental Nuclear Magnetic Resonance Conference : Abstract book / ed. Jeffrey C. Hoch. - p. 262
További szerzők:Gyöngyösi Tamás (1989-) (vegyész) Boros Sándor Luy, Burkhard Kövér Katalin, E. (1956-) (vegyész)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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