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001-es BibID:	BIBFORM110018
035-os BibID:	(Scopus)85150518249
Első szerző:	Biró Erika
Cím:	Daily serum phosphate increase as early and reliable indicator of kidney injury in children with leukemia and lymphoma developing tumor lysis syndrome / Biró Erika, Erdélyi Dániel, Varga Petra, Sinkó Mária, Bartyik Katalin, Kovács Gábor, Ottóffy Gábor, Vincze Ferenc, Szegedi István, Kiss Csongor, Szabó Tamás
Dátum:	2023
ISSN:	0931-041X
Megjegyzések:	Abstract Background Tumor lysis syndrome (TLS) and its most serious complication, acute kidney injury (AKI) are one of the emergency conditions in onco-hematology. It is difcult to predict the degree of kidney involvement. Therefore, we studied children with leukemia and lymphoma treated in four Hungarian tertiary centers (inpatient university clinics) retrospectively (2006?2016) from a nephrological aspect. Method Data of 31 pediatric patients were obtained from electronic- and paper-based medical records. Physical status, laboratory test results, treatments, and outcomes were assessed. Patients were analyzed according to both "traditional" TLS groupings, as laboratory TLS or clinical TLS, and nephrological aspect based on pRIFLE classifcation, as mild or severe AKI. Results Signifcant diferences were found between the changes in parameters of phosphate homeostasis and urea levels in both classifcations. Compared to age-specifc normal phosphate ranges, before the development of TLS, hypophosphatemia was common (19/31 cases), while in the post-TLS period, hyperphosphatemia was observed (26/31 cases) most frequently. The rate of daily change in serum phosphate level was signifcant in the nephrological subgroups, but peaks of serum phosphate level show only a moderate increase. The calculated cut-of value of daily serum phosphate level increased before AKI was 0.32 mmol/L per ROC analysis for severe TLS?AKI. The 24-h urinalysis data of eight patients revealed transiently increased phosphate excretion only in those patients with TLS in whom serum phosphate was elevated in parallel. Conclusion Daily serum phosphate level increase can serve as a prognostic factor for the severity of pediatric TLS, as well as predict the severity of kidney involvement.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Pediatric Nephrology. - 38 : 9 (2023), p. 3117-3127. -
További szerzők:	Erdélyi Dániel Varga Petra (1981-) (orvos) Sinkó Mária Bartyik Katalin (haematológus) Kovács Gábor (gyermekhaematológus Budapest) Ottóffy Gábor Vincze Ferenc (1987-) (táplákozástudományi szakember, epidemiológus) Szegedi István (1969-) (hematológus, onkológus, nefrológus) Kiss Csongor (1956-) (hematológus, onkológus) Szabó Tamás (1968-) (gyermekgyógyász)
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