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001-es BibID:	BIBFORM105799
035-os BibID:	(WOS)000712803800001 (Scopus)85118154608 (cikkazonosító)1577
Első szerző:	Babszki Gergely
Cím:	COVID-19 Infection Alters the Microbiome : elite Athletes and Sedentary Patients Have Similar Bacterial Flora / Gergely Babszky, Ferenc Torma, Dora Aczel, Peter Bakonyi, Zoltan Gombos, Janos Feher, Dóra Szabó, Balázs Ligeti, Sándor Pongor, Laszlo Balogh, Anikó Pósa, Zsolt Radak
Dátum:	2021
ISSN:	2073-4425
Megjegyzések:	Regular exercise can upgrade the efficiency of the immune system and beneficially alter the composition of the gastro-intestinal microbiome. We tested the hypothesis that active athletes have a more diverse microbiome than sedentary subjects, which could provide better protection against COVID-19 during infection. Twenty active competing athletes (CA) (16 male and 4 females of the national first and second leagues), aged 24.15 ? 4.7 years, and 20 sedentary subjects (SED) (15 male and 5 females), aged 27.75 ? 7.5 years, who had been diagnosed as positive for COVID-19 by a PCR test, served as subjects for the study. Fecal samples collected five to eight days after diagnosis and three weeks after a negative COVID-19 PCR test were used for microbiome analysis. Except for two individuals, all subjects reported very mild and/or mild symptoms of COVID-19 and stayed at home under quarantine. Significant differences were not found in the bacterial flora of trained and untrained subjects. On the other hand, during COVID-19 infection, at the phylum level, the relative abundance of Bacteroidetes was elevated during COVID-19 compared to the level measured three weeks after a negative PCR test (p < 0.05) when all subjects were included in the statistical analysis. Since it is known that Bacteroidetes can suppress toll-like receptor 4 and ACE2-dependent signaling, thus enhancing resistance against pro-inflammatory cytokines, it is suggested that Bacteroidetes provide protection against severe COVID-19 infection. There is no difference in the microbiome bacterial flora of trained and untrained subjects during and after a mild level of COVID-19 infection.
Tárgyszavak:	Orvostudományok Sporttudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Bacteroidetes COVID-19 microbiome exercise inflammation
Megjelenés:	Genes. - 12 : 10 (2021), p. 1-11. -
További szerzők:	Torma Ferenc Aczél Dóra Bakonyi Péter Gombos Zoltán Fehér János Szabó Dóra Ligeti Balázs Pongor Sándor Balogh László (1976-) (sporttudomány) Pósa Anikó Radák Zsolt
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM105801
035-os BibID:	(WOS)000456026500006 (Scopus)85056218353
Első szerző:	Radák Zsolt
Cím:	Exercise effects on physiological function during aging / Zsolt Radak, Ferenc Torma, Istvan Berkes, Sataro Goto, Tatsuya Mimura, Aniko Posa, Laszlo Balogh, Istvan Boldogh, Katsuhiko Suzuki, Mitsuru Higuchi, Erika Koltai
Dátum:	2019
ISSN:	0891-5849
Megjegyzések:	The decrease in cognitive/motor functions and physical abilities severely affects the aging population in carrying out daily activities. These disabilities become a burden on individuals, families and society in general. It is known that aging conditions are ameliorated with regular exercise, which attenuates the age-associated decline in maximal oxygen uptake (VO2max), production of reactive oxygen species (ROS), decreases in oxidative damage to molecules, and functional impairment in various organs. While benefits of physical exercise are well-documented, the molecular mechanisms responsible for functional improvement and increases in health span are not well understood. Recent findings imply that exercise training attenuates the age-related deterioration in the cellular housekeeping system, which includes the proteasome, Lon protease, autophagy, mitophagy, and DNA repair systems, which beneficially impacts multiple organ functions. Accumulating evidence suggests that exercise lessens the deleterious effects of aging. However, it seems unlikely that systemic effects are mediated through a specific biomarker. Rather, complex multifactorial mechanisms are involved to maintain homeostatic functions that tend to decline with age.
Tárgyszavak:	Orvostudományok Sporttudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Cellular housekeeping Exercise Mitochondrial dynamics VO2max
Megjelenés:	Free Radical Biology And Medicine. - 132 (2019), p. 33-41. -
További szerzők:	Torma Ferenc Berkes István Goto, Sataro Mimura, Tatsuya Pósa Anikó Balogh László (1976-) (sporttudomány) Boldogh István Suzuki, Katsuhiko Higuchi, Mitsuru Koltai Erika
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001-es BibID:	BIBFORM105802
035-os BibID:	(WOS)000403328700027 (Scopus)85014628150
Első szerző:	Radák Zsolt
Cím:	Exercise, oxidants, and antioxidants change the shape of the bell-shaped hormesis curve / Zsolt Radak, Kazunari Ishihara, Eva Tekus, Csaba Varga, Aniko Posa, Laszlo Balogh, Istvan Boldogh, Erika Koltai
Dátum:	2017
ISSN:	2213-2317
Megjegyzések:	It is debated whether exercise-induced ROS production is obligatory to cause adaptive response. It is also claimed that antioxidant treatment could eliminate the adaptive response, which appears to be systemic and reportedly reduces the incidence of a wide range of diseases. Here we suggest that if the antioxidant treatment occurs before the physiological function-ROS dose-response curve reaches peak level, the antioxidants can attenuate function. On the other hand, if the antioxidant treatment takes place after the summit of the bell-shaped dose response curve, antioxidant treatment would have beneficial effects on function. We suggest that the effects of antioxidant treatment are dependent on the intensity of exercise, since the adaptive response, which is multi pathway dependent, is strongly influenced by exercise intensity. It is further suggested that levels of ROS concentration are associated with peak physiological function and can be extended by physical fitness level and this could be the basis for exercise pre-conditioning. Physical inactivity, aging or pathological disorders increase the sensitivity to oxidative stress by altering the bell-shaped dose response curve.
Tárgyszavak:	Orvostudományok Sporttudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Redox Biology. - 12 (2017), p. 285-290. -
További szerzők:	Ishihara, Kazunari Tekus Éva Varga Csaba Pósa Anikó Balogh László (1976-) (sporttudomány) Boldogh István Koltai Erika
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM105803
035-os BibID:	(WOS)000382213400019 (Scopus)84980413704
Első szerző:	Radák Zsolt
Cím:	Physical exercise, reactive oxygen species and neuroprotection / Zsolt Radak, Katsuhiko Suzuki, Mitsuru Higuchi, Laszlo Balogh, Istvan Boldogh, Erika Koltai
Dátum:	2016
ISSN:	0891-5849
Megjegyzések:	Regular exercise has systemic beneficial effects, including the promotion of brain function. The adaptive response to regular exercise involves the up-regulation of the enzymatic antioxidant system and modulation of oxidative damage. Reactive oxygen species (ROS) are important regulators of cell signaling. Exercise, via intensity-dependent modulation of metabolism and/or directly activated ROS generating enzymes, regulates the cellular redox state of the brain. ROS are also involved in the self-renewal and differentiation of neuronal stem cells and the exercise-mediated neurogenesis could be partly associated with ROS production. Exercise has strong effects on the immune system and readily alters the production of cytokines. Certain cytokines, especially IL-6, IL-1, TNF-?, IL-18 and IFN gamma, are actively involved in the modulation of synaptic plasticity and neurogenesis. Cytokines can also contribute to ROS production. ROS-mediated alteration of lipids, protein, and DNA could directly affect brain function, while exercise modulates the accumulation of oxidative damage. Oxidative alteration of macromolecules can activate signaling processes, membrane remodeling, and gene transcription. The well known neuroprotective effects of exercise are partly due to redox-associated adaptation.
Tárgyszavak:	Orvostudományok Sporttudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Brain plasticity Exercise Neurogenesis Neuronal stem cells Redox signaling.
Megjelenés:	Free Radical Biology And Medicine. - 98 (2016), p. 187-196. -
További szerzők:	Suzuki, Katsuhiko Higuchi, Mitsuru Balogh László (1976-) (sporttudomány) Boldogh István Koltai Erika
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