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001-es BibID:BIBFORM105801
035-os BibID:(WOS)000456026500006 (Scopus)85056218353
Első szerző:Radák Zsolt
Cím:Exercise effects on physiological function during aging / Zsolt Radak, Ferenc Torma, Istvan Berkes, Sataro Goto, Tatsuya Mimura, Aniko Posa, Laszlo Balogh, Istvan Boldogh, Katsuhiko Suzuki, Mitsuru Higuchi, Erika Koltai
Megjegyzések:The decrease in cognitive/motor functions and physical abilities severely affects the aging population in carrying out daily activities. These disabilities become a burden on individuals, families and society in general. It is known that aging conditions are ameliorated with regular exercise, which attenuates the age-associated decline in maximal oxygen uptake (VO2max), production of reactive oxygen species (ROS), decreases in oxidative damage to molecules, and functional impairment in various organs. While benefits of physical exercise are well-documented, the molecular mechanisms responsible for functional improvement and increases in health span are not well understood. Recent findings imply that exercise training attenuates the age-related deterioration in the cellular housekeeping system, which includes the proteasome, Lon protease, autophagy, mitophagy, and DNA repair systems, which beneficially impacts multiple organ functions. Accumulating evidence suggests that exercise lessens the deleterious effects of aging. However, it seems unlikely that systemic effects are mediated through a specific biomarker. Rather, complex multifactorial mechanisms are involved to maintain homeostatic functions that tend to decline with age.
Tárgyszavak:Orvostudományok Sporttudományok idegen nyelvű folyóiratközlemény külföldi lapban
Cellular housekeeping
Mitochondrial dynamics
Megjelenés:Free Radical Biology And Medicine. - 132 (2019), p. 33-41. -
További szerzők:Torma Ferenc Berkes István Goto, Sataro Mimura, Tatsuya Pósa Anikó Balogh László (1976-) (sporttudomány) Boldogh István Suzuki, Katsuhiko Higuchi, Mitsuru Koltai Erika
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