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001-es BibID:BIBFORM125172
035-os BibID:(scopus)85207507392 (WOS)001341961400001
Első szerző:Berta Eszter (belgyógyász)
Cím:Low Serum Fibroblast Growth Factor 21 Level and Its Altered Regulation by Thyroid Hormones in Patients with Hashimoto's Thyroiditis on Levothyroxine Substitution / Berta Eszter, Halmi Sándor, Molnár István, Hutkai Dávid, Csiha Sára, Bhattoa Harjit Pal, Lőrincz Hajnalka, Somodi Sándor, Katkó Mónika, Harangi Mariann, Paragh György, Nagy Endre V., Bodor Miklós
Dátum:2024
ISSN:2218-1989
Megjegyzések:Background/Objectives: Fibroblast growth factor 21 (FGF21) is a hormonal regulator of lipid and glucose metabolism exerting protection against atherosclerosis by multiple actions on the blood vessels, liver, and adipose tissues. We aimed to investigate serum FGF21 level and its relation to thyroid hormones and metabolic parameters among patients with Hashimoto's thyroiditis (HT). Methods: Eighty patients with HT on levothyroxine treatment and eighty-two age- and BMI-matched adults without thyroid disease serving as controls were enrolled. Serum FGF21 concentrations were determined with an enzyme-linked immunosorbent assay. Results: Median serum FGF21 level was significantly lower in HT patients compared with controls (74.2 (33.4?148.3) pg/mL vs. 131.9 (44.8?236.3) pg/mL; p = 0.03). We found a positive correlation between FGF21 and age, triglyceride, total cholesterol, and low-density lipoprotein cholesterol in both groups, while thyroid stimulating hormone and C-reactive protein showed a positive correlation, and thyroxine had an inverse correlation with FGF21 only in control subjects. According to multiple regression analyses, thyroid status is the main predictor of FGF21 in healthy controls, while it is not a significant predictor of FGF21 among HT patients on levothyroxine supplementation therapy. Conclusions: Our results indicate that the physiological role of thyroid function in the regulation of FGF21 synthesis is impaired in HT patients, which may contribute to the metabolic alterations characteristic of HT patients.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
thyroid
fibroblast growth factor 21
FGF21
Hashimoto's thyroiditis
levothyroxine
hyperlipidemia
hypothyroidism
Megjelenés:Metabolites. - 14 : 10 (2024), p. 1-10. -
További szerzők:Halmi Sándor (1986-) (belgyógyász) Molnár István Hutkai Dávid (1990-) (belgyógyász, nefrológus) Csiha Sára (1985-) (Biológus) Bhattoa Harjit Pal (1973-) (laboratóriumi szakorvos) Lőrincz Hajnalka (1986-) (biológus) Somodi Sándor (1977-) (belgyógyász) Katkó Mónika (1980-) (biológus) Harangi Mariann (1974-) (belgyógyász, endokrinológus) Paragh György (1953-) (belgyógyász) Nagy Endre V. (1957-) (belgyógyász, endokrinológus) Bodor Miklós (1969-) (belgyógyász, endokrinológus)
Pályázati támogatás:K142273
OTKA
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DOI
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001-es BibID:BIBFORM125045
Első szerző:Halmi Sándor (belgyógyász)
Cím:Single center experience in localization of insulinoma by selective intraarterial calcium stimulation angiography : a case series of 15 years / Halmi Sándor, Berta Eszter, Diószegi Ágnes, Sira Lívia, Fülöp Péter, Nagy Endre V., Győry Ferenc, Kanyári Zsolt, Tóth Judit, Bhattoa Harjit Pal, Bodor Miklós
Dátum:2024
ISSN:1664-2392
Megjegyzések:Background: Insulinomas are rare insulin-secreting neuroendocrine neoplasms of the pancreas. First-line treatment is the surgical removal of the tumor, however, the localization with standard imaging techniques is often challenging. With the help of selective intraarterial calcium stimulation the insulinoma's localization can be narrowed down to one third of the pancreas which the selected artery supplies. Objective: We aimed to prove the usefulness of the calcium stimulation test in case of 9 patients treated between 2006 and 2021 diagnosed with endogenous hyperinsulinemic hypoglycemia confirmed by fasting test, where conventional imaging methods, like transabdominal ultrasound, CT or MRI failed to detect the source of hyperinsulinemia. Methods: We performed selective intraarterial calcium stimulation with angiography with calcium gluconate injected to the main supporting arteries of the pancreas (splenic, superior mesenteric and gastroduodenal arteries); blood samples were obtained from the right hepatic vein before, and 30, 60 and 120 seconds after calcium administration. Results: With selective angiography we found a significant elevation of insulin levels taken from the right hepatic vein in five of the nine cases. On histopathology, the lesions were between 1-2 cm, in one case malignancy was also confirmed. In four patients we found a significant rise of insulin levels obtained from all catheterized sites, which confirmed the diagnosis of nesidioblastosis. In three cases no surgery was performed, and the symptoms relieved with medical treatment. Conclusions: Selective intraarterial calcium stimulation remains an important tool in localization of the source of insulin excess, especially in cases where other diagnostic modalities fail.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
insulinoma
selective intraarterial calcium stimulation
ASVS
nesidioblastosis
hyperinsulinemic hypoglycemia
pancreas
functioning neuroendocrine tumor
Megjelenés:Frontiers in Endocrinology. - 15 (2024), p. 1-7. -
További szerzők:Berta Eszter (1980-) (belgyógyász) Diószegi Ágnes (1987-) (belgyógyász) Sira Lívia (1973-) (endokrinológus) Fülöp Péter (1974-) (belgyógyász, endokrinológus, lipidológus) Nagy Endre V. (1957-) (belgyógyász, endokrinológus) Győry Ferenc (1964-) (sebész) Kanyári Zsolt (1964-) (orvos) Tóth Judit (1978-) (laboratóriumi szakorvos) Bhattoa Harjit Pal (1973-) (laboratóriumi szakorvos) Bodor Miklós (1969-) (belgyógyász, endokrinológus)
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DOI
Intézményi repozitóriumban (DEA) tárolt változat
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