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001-es BibID:	BIBFORM083758
035-os BibID:	(WoS)000521356600028 (Scopus)85079836539
Első szerző:	Csernus Brigitta (élelmiszerbiztonsági és -minőségi mérnök)
Cím:	Effect of Carotenoids, Oligosaccharides and Anthocyanins on Growth Performance, Immunological Parameters and Intestinal Morphology in Broiler Chickens Challenged with Escherichia coli Lipopolysaccharide / Brigitta Csernus, Sándor Biró, László Babinszky, István Komlósi, András Jávor , László Stündl, Judit Remenyik, Péter Bai, János Oláh, Georgina Pesti-Asbóth, Levente Czeglédi
Dátum:	2020
ISSN:	2076-2615
Megjegyzések:	This study was conducted to investigate the effect of carotenoid, oligosaccharide and anthocyanin supplementation in broiler diets under Escherichia coli lipopolysaccharide (LPS) challenge. Ross 308 chickens were fed 5 diets: basal diet (control diet), diet supplemented with beta-glucan in 0.05% (positive control) and diets with 0.5% carotenoid-, oligosaccharide- or anthocyanin contents. On the 26th days of age, chickens were challenged intraperitoneally 2 mg LPS per kg of body weight. 12 h after injection, birds were euthanized, then spleen and ileum samples were collected. LPS induced increased relative mRNA expression of splenic (p = 0.0445) and ileal (p = 0.0435) interleukin-1 beta (IL-1 beta), which was lower in the spleen in carotenoid (p = 0.0114), oligosaccharide (p = 0.0497) and anthocyanin (p = 0.0303)-treated chickens compared to LPS-injected control birds. Dietary supplementation of carotenoids also decreased relative gene expression of splenic interleukin-6 (IL-6) (p = 0.0325). In the ileum, beta-glucan supplementation showed lower relative mRNA expression of toll-like receptor 5 (TLR-5) (p = 0.0387) compared to anthocyanin treatment. Gene expression of both splenic and ileal interferon-alpha (IFN-alpha), interferon-gamma (IFN-gamma), toll-like receptor 4 (TLR-4) and toll-like receptor 5 (TLR-5) were not influenced by dietary supplements. In conclusion, carotenoids, oligosaccharides and anthocyanins could partially mitigate the immune stress caused by LPS challenge. All of the compounds impacted longer villus height (p < 0.0001), villus height:crypt depth ratios were higher after beta-glucan (p < 0.0001) and anthocyanin (p = 0.0063) supplementations and thickened mucosa was observed in beta-glucan (p < 0.0001), oligosaccharide (p < 0.0001) and anthocyanin (p = 0.048) treatments. All of these findings could represent a more effective absorption of nutrients.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Animals. - 10 : 2 (2020), p. 1-20. -
További szerzők:	Biró Sándor (1949-) (molekuláris genetikus) Babinszky László (1950-) (agrár) Komlósi István (1960-) (agrármérnök) Jávor András (1952-) (agrármérnök) Stündl László (1970-) (agrármérnök) Gálné Remenyik Judit (1965-) (kémia tanár, okleveles vegyész) Bai Péter (1976-) (biokémikus) Oláh János (1976-) (állattenyésztés) Pesti-Asbóth Georgina (1990-) (élelmiszerbiztonsági és -minőségi mérnök) Czeglédi Levente (1977-) (agrármérnök)
Pályázati támogatás:	GINOP-2.3.2-15-2016-00042 GINOP EFOP-3.6.3-VEKOP-16-2017-00008 EFOP NKFIH-1150-6/2019 NKFIH
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001-es BibID:	BIBFORM123835
035-os BibID:	(WoS)001311042300001 (Scopus)85203628397
Első szerző:	Ndunguru, Sawadi Fransisco (1980-)
Cím:	Embryonic Leucine Promotes Early Postnatal Growth via mTOR Signalling in Japanese Quails / Sawadi F. Ndunguru, Gebrehaweria K. Reda, Brigitta Csernus, Renáta Knop, James K. Lugata, Csaba Szabó, Ádám Z. Lendvai, Levente Czeglédi
Dátum:	2024
ISSN:	2076-2615
Megjegyzések:	However, the specific mechanisms by which nutrients influence avian growth remain largely unknown. Amino acids can directly interact with the nutrient-sensing pathways, such as the insulin-like growth factor 1 (IGF-1)/mechanistic target of rapamycin (mTOR) pathways, which are known to regulate growth. We examined the effects of embryonic leucine on gene expression and phenotypic growth in Japanese quails by injecting 2.5 mg leucine or saline (control) into Japanese quail eggs on the tenth day of incubation and incubating them under standard conditions. The treatment groups had similar hatching success and size at hatching. However, between 3 and 7 days post-hatching, quails treated with embryonic leucine showed increased growth in body mass and wing, tarsus, head, and intestinal lengths, lasting up to 21 days. The hepatic expression of IGF1, IGF1R, mTOR, and RPS6K1 was upregulated in leucine-treated quails, while the expression of FOXO1 remained unaffected. In conclusion, a subtle increase in embryonic leucine may induce developmental programming effects in Japanese quail by interacting with the IGF-1/mTOR nutrient-sensing pathway to promote growth. This study highlights the role of embryonic amino acids as crucial nutrients for enhancing growth. It provides valuable insight into nutrient intervention strategies during embryonic development to potentially improve poultry growth performance.
Tárgyszavak:	Agrártudományok Állattenyésztési tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk birds physiology nutrition amino acid mechanistic target of rapamycin
Megjelenés:	Animals. - 14 : 17 (2024), p. 1-16. -
További szerzők:	Reda, Gebrehaweria Kidane (1986-) (Animal Sceince) Csernus Brigitta (1991-) (élelmiszerbiztonsági és -minőségi mérnök) Knop Renáta (1983-) (állatorvos) Lugata, James Kachungwa (1992-) (Ph.D hallgató) Szabó Csaba (1968-) (agrármérnök) Lendvai Ádám Zoltán (1977-) (biológus) Czeglédi Levente (1977-) (agrármérnök)
Pályázati támogatás:	K139021 OTKA
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001-es BibID:	BIBFORM129773
Első szerző:	Szabó Csaba (agrármérnök)
Cím:	The Effect of Poppy Oil on Egg Production and Calcium Metabolism in Japanese Quail / Csaba Szabó, Xénia Ozsváth, Brigitta Csernus, Gabriella Gulyás, Márta Horváth, Levente Czeglédi, János Oláh, Nafiatur Rizqoh, Gabriele Achille, János Posta
Dátum:	2025
ISSN:	2076-2615
Megjegyzések:	Consumers tend to favor natural dietary supplements to improve their health. However, vendors rarely cite scientific evidence to justify these claims. In the case of poppy oil, it is often mentioned as having a positive effect on Ca metabolism-related disorders, but no proof has been provided. Therefore, the aim of our trial was to test the possible effect of poppy oil on calcium metabolism using Japanese quail layers as a model animal. A total of 120 four-week-old quail were divided into three dietary treatments (four cages per treatment, with ten birds in each cage): a control group (using sunflower oil as the energy source in the diet), 0.5%, and 1% poppy oil supplementation (replacing sunflower oil). Egg production, eggshell thickness, eggshell strength, and egg yolk color were investigated. Ca retention was determined using the acid-insoluble ash method. At the end of the experiment, two birds per cage were sacrificed, and uterus and jejunum samples were collected for gene expression analyses. Poppy oil supplementation improved egg production in terms of intensity, egg weight, and eggmass production. The thickness and eggshell strength decreased when 1% poppy oil was fed to the animals, while Ca retention improved. Poppy oil supplementation increased the expression of Ca transporter genes (CALB1, SLC8A1, and SLC26A9) in the uterus and ITPR1 in the jejunum. Our results indicate a possible effect of poppy oil on Ca metabolism. Further studies are needed to identify the active compound and to understand the mode of action.
Tárgyszavak:	Agrártudományok Állattenyésztési tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk poppy oil egg production egg quality calcium Japanese quail
Megjelenés:	Animals. - 15 : 9 (2025), p. 1-14. -
További szerzők:	Ozsváth Xénia Erika Csernus Brigitta (1991-) (élelmiszerbiztonsági és -minőségi mérnök) Gulyás Gabriella (1985-) (agrár) Horváth Márta (1987-) (állattenyésztő mérnök) Czeglédi Levente (1977-) (agrármérnök) Oláh János (1976-) (állattenyésztés) Rizqoh, Nafiatur Achille, Gabriele Posta János (1978-) (informatika tanár, agrármérnök)
Pályázati támogatás:	ÚNKP-23-4 Egyéb
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