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001-es BibID:	BIBFORM128273
Első szerző:	Csernus Brigitta (élelmiszerbiztonsági és -minőségi mérnök)
Cím:	Impact of Selected Natural Bioactive Substances on Immune Response and Tight Junction Proteins in Broiler Chickens / Brigitta Csernus, Georgina Pesti-Asbóth, Judit Remenyik, Sándor Biró, László Babinszky, László Stündl, János Oláh, Nóra Vass, Levente Czeglédi
Dátum:	2025
Megjegyzések:	This study was conducted to examine the effect of dietary natural compounds, such as ?-glucan, carotenoids, oligosaccharides and anthocyanins, on immune response and tight junction proteins in broiler chickens. A total of 900 one-day-old chickens were allocated to five treatments in three floor pens (replicates) of 60 broilers per pen. Chickens were fed five diets: a control (basal) diet, a diet supplemented with ?-glucan at 0.05%, or diets supplemented with carotenoids, oligosaccharides or anthocyanins at 0.5% of each compound. Male broilers were randomly selected for sample collections. On Day 25, plasma samples were collected from the brachial vein. On Day 26, six broilers were intraperitoneally injected with 2 mg of lipopolysaccharide per kg of body weight. Twelve hours later (Day 27), blood and ileum samples were collected to determine immune parameters and tight junction proteins using ELISA assays. The results showed that anthocyanin supplementation reduced the level of interleukin-1? compared to the lipopolysaccharide-injected control group (p = 0.047), which suggests that anthocyanin could partly alleviate the inflammation. Carotenoids reached a lower level of interleukin-6 compared to the ?-glucan treatment (p = 0.0466). ?-Glucan (p = 0.0382) and oligosaccharides (p = 0.0449) increased the level of plasma immunoglobulin G compared to the challenged control group, which may indicate an enhanced humoral immunity. Furthermore, ?-glucan (except for occludin 2), carotenoids, oligosaccharides and anthocyanins increased (p < 0.05) the levels of ileal zonula occludens-1, occludin 1 and occludin 2 compared to the lipopolysaccharide-challenged control chickens. This may suggest that all the bioactive substances improved the gut barrier function. The plasma levels of tight junction proteins show higher concentrations in lipopolysaccharide-challenged groups compared to the non-challenged groups (p < 0.05). This may refer to the tight junction disruption and appearance in circulation as a reflection of lipopolysaccharide exposure.
Tárgyszavak:	Agrártudományok Állattenyésztési tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk broiler chicken cytokine immune response immunoglobulin natural bioactive compounds tight junction proteins
Megjelenés:	Veterinary Medicine and Science. - 11 : 2 (2025), p. 1-11. -
További szerzők:	Pesti-Asbóth Georgina (1990-) (élelmiszerbiztonsági és -minőségi mérnök) Gálné Remenyik Judit (1965-) (kémia tanár, okleveles vegyész) Biró Sándor (1949-) (molekuláris genetikus) Babinszky László (1950-) (agrár) Stündl László (1970-) (agrármérnök) Oláh János (1976-) (állattenyésztés) Vass Nóra (1983-) (állatorvos) Czeglédi Levente (1977-) (agrármérnök)
Pályázati támogatás:	EFOP-3.6.3-VEKOP-16-2017-00008 EFOP GINOP-2.3.2-15-2016-00042 GINOP ÚNKP-23-4 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM101046
Első szerző:	Csernus Brigitta (élelmiszerbiztonsági és -minőségi mérnök)
Cím:	The effect of β-glucan, carotenoids, oligosaccharides and anthocyanins on bacteria groups of excreta in broiler chickens / Brigitta Csernus, Sándor Biró, László Babinszky, László Stündl, Judit Remenyik, Georgina Pesti-Asbóth, János Oláh, Levente Czeglédi
Dátum:	2022
ISSN:	1587-1282
Megjegyzések:	This study was conducted to examine the effect of natural compounds, such as ?-glucan, carotenoids, oligosaccharides, and anthocyanins in the diet on bacteria gropus of excreta in Ross 308 broiler chickens. Chickens were fed 5 diets: control (basal) diet, a diet supplemented by ?-glucan at 0.05%, and diets supplemented by carotenoids, oligosaccharides, or anthocyanins at 0.5% of each compound. On experimental day 19, excreta were collected to determine the proportion of Lactobacillus, Bifidobacterium, Campylobacter, Clostridium, and Escherichia coli. Samples were collected aseptically and snap-frozen in liquid nitrogen. Bacterial DNA was isolated from samples, then polymerase chain reaction using primer pairs designed to the 16S rDNA of bacterial groups were applied to define the proportion of the mentioned bacteria. Another universal primer pair was used to amplify a region of 16S rDNA of all the examined bacteria. Proportion of each bacterial groups was determined relatively to the intensity of universal PCR product band by gel documenting system and ImageLab software. Based on the results, carotenoids and anthocyanins increased the proportion of Bifidobacterium, which might imply the beneficial effects of the mentioned compounds on the bacteria composition of excreta.
Tárgyszavak:	Agrártudományok Állattenyésztési tudományok idegen nyelvű folyóiratközlemény hazai lapban folyóiratcikk
Megjelenés:	Agrártudományi Közlemények = Acta agraria Debreceniensis. - 1 (2022), p. 15-20. -
További szerzők:	Biró Sándor (1949-) (molekuláris genetikus) Babinszky László (1950-) (agrár) Stündl László (1970-) (agrármérnök) Gálné Remenyik Judit (1965-) (kémia tanár, okleveles vegyész) Pesti-Asbóth Georgina (1990-) (élelmiszerbiztonsági és -minőségi mérnök) Oláh János (1976-) (állattenyésztés) Czeglédi Levente (1977-) (agrármérnök)
Pályázati támogatás:	GINOP-2.3.2-15-2016-00042 GINOP EFOP-3.6.3-VEKOP-16-2017-00008 EFOP
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM083758
035-os BibID:	(WoS)000521356600028 (Scopus)85079836539
Első szerző:	Csernus Brigitta (élelmiszerbiztonsági és -minőségi mérnök)
Cím:	Effect of Carotenoids, Oligosaccharides and Anthocyanins on Growth Performance, Immunological Parameters and Intestinal Morphology in Broiler Chickens Challenged with Escherichia coli Lipopolysaccharide / Brigitta Csernus, Sándor Biró, László Babinszky, István Komlósi, András Jávor , László Stündl, Judit Remenyik, Péter Bai, János Oláh, Georgina Pesti-Asbóth, Levente Czeglédi
Dátum:	2020
ISSN:	2076-2615
Megjegyzések:	This study was conducted to investigate the effect of carotenoid, oligosaccharide and anthocyanin supplementation in broiler diets under Escherichia coli lipopolysaccharide (LPS) challenge. Ross 308 chickens were fed 5 diets: basal diet (control diet), diet supplemented with beta-glucan in 0.05% (positive control) and diets with 0.5% carotenoid-, oligosaccharide- or anthocyanin contents. On the 26th days of age, chickens were challenged intraperitoneally 2 mg LPS per kg of body weight. 12 h after injection, birds were euthanized, then spleen and ileum samples were collected. LPS induced increased relative mRNA expression of splenic (p = 0.0445) and ileal (p = 0.0435) interleukin-1 beta (IL-1 beta), which was lower in the spleen in carotenoid (p = 0.0114), oligosaccharide (p = 0.0497) and anthocyanin (p = 0.0303)-treated chickens compared to LPS-injected control birds. Dietary supplementation of carotenoids also decreased relative gene expression of splenic interleukin-6 (IL-6) (p = 0.0325). In the ileum, beta-glucan supplementation showed lower relative mRNA expression of toll-like receptor 5 (TLR-5) (p = 0.0387) compared to anthocyanin treatment. Gene expression of both splenic and ileal interferon-alpha (IFN-alpha), interferon-gamma (IFN-gamma), toll-like receptor 4 (TLR-4) and toll-like receptor 5 (TLR-5) were not influenced by dietary supplements. In conclusion, carotenoids, oligosaccharides and anthocyanins could partially mitigate the immune stress caused by LPS challenge. All of the compounds impacted longer villus height (p < 0.0001), villus height:crypt depth ratios were higher after beta-glucan (p < 0.0001) and anthocyanin (p = 0.0063) supplementations and thickened mucosa was observed in beta-glucan (p < 0.0001), oligosaccharide (p < 0.0001) and anthocyanin (p = 0.048) treatments. All of these findings could represent a more effective absorption of nutrients.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Animals. - 10 : 2 (2020), p. 1-20. -
További szerzők:	Biró Sándor (1949-) (molekuláris genetikus) Babinszky László (1950-) (agrár) Komlósi István (1960-) (agrármérnök) Jávor András (1952-) (agrármérnök) Stündl László (1970-) (agrármérnök) Gálné Remenyik Judit (1965-) (kémia tanár, okleveles vegyész) Bai Péter (1976-) (biokémikus) Oláh János (1976-) (állattenyésztés) Pesti-Asbóth Georgina (1990-) (élelmiszerbiztonsági és -minőségi mérnök) Czeglédi Levente (1977-) (agrármérnök)
Pályázati támogatás:	GINOP-2.3.2-15-2016-00042 GINOP EFOP-3.6.3-VEKOP-16-2017-00008 EFOP NKFIH-1150-6/2019 NKFIH
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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