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001-es BibID:	BIBFORM102758
035-os BibID:	(cikkazonosító)925 (WOS)000832003000001 (Scopus)85135101139
Első szerző:	Lukács Luca (hallgató)
Cím:	Evaluating the Phagocytic Index of Peripheral Leukocytes in Endometriosis by Plasma Experiments / Lukács Luca, Kovács Anna Rebeka, Pál László, Szűcs Sándor, Lampé Rudolf
Dátum:	2022
ISSN:	1010-660X 1648-9144
Megjegyzések:	Background and Objectives: Endometriosis is a benign, chronic disease, that negatively influences the quality of life of affected women and is responsible for a remarkable amount of infertility. The pathophysiology of the disease is still not clarified, but the insufficient immune surveillance plays a significant role in it. The phagocyte function of innate immune cells may play a role in the elimination of ectopic endometrium. The purpose of this study is to examine the phagocyte function of neutrophil granulocytes and monocytes, incubated in heat-inactivated and not-inactivated plasma samples from healthy women and from women with endometriosis before and after the surgical treatment. Materials and Methods: Blood samples were collected from eight preoperative and eight postoperative patients with endometriosis before and after the surgical treatment, and from 16 healthy patients as controls. Neutrophil granulocytes, monocytes and blood plasma samples were isolated. Cells were incubated in different plasma samples, and the phagocytic index was determined with a fluorescence microscope. Results: The phagocytic index of granulocytes and monocytes isolated from patients with endometriosis was significantly decreased compared to healthy women after the cells were incubated in their own plasma. Preoperatively isolated cells from patients with endometriosis demonstrated an improved phagocyte function after incubating them in plasma samples from healthy controls. In contrast, the phagocytic activity of cells from healthy women significantly reduced after being incubated in the plasma of preoperative endometriosis patients. The heat-inactivation of plasma samples did not affect the results. Conclusions: Active endometriosis lesions may produce heat-stable systemic immunomodulatory factors, which reduced the phagocyte function of peripheral monocytes and neutrophil granulocytes. The phagocyte function of these cells can be normalized after the complete surgical removal of endometriosis, which then demonstrates similar values as in healthy women.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk endometriosis innate immunity phagocyte function plasma experiment monocyte neutrophil granulocyte
Megjelenés:	Medicina. - 58 : 7 (2022), p. 1-12. -
További szerzők:	Kovács Anna Rebeka (1993-) (általános orvos) Pál László (1987-) (népegészségügyi szakember, egészségfejlesztő) Szűcs Sándor (1958-) (biokémikus, vegyész) Lampé Rudolf (1983-) (szülész-nőgyógyász)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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