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001-es BibID:	BIBFORM092840
035-os BibID:	(cikkazonosító)347 (WoS)000633434800001 (Scopus)85101254453
Első szerző:	Bagoly Zsuzsa (orvos)
Cím:	Incorporation of [alfa]2-Plasmin Inhibitor into Fibrin Clots and Its Association with the Clinical Outcome of Acute Ischemic Stroke Patients / Bagoly Zsuzsa, Baráth Barbara, Orbán-Kálmándi Rita, Szegedi István, Bogáti Réka, Sarkady Ferenc, Csiba László, Katona Éva
Dátum:	2021
ISSN:	2218-273X
Megjegyzések:	Cross-linking of ?2-plasmin inhibitor (?2-PI) to fibrin by activated factor XIII (FXIIIa) is essential for the inhibition of fibrinolysis. Little is known about the factors modifying ?2-PI incorporation into the fibrin clot and whether the extent of incorporation has clinical consequences. Herein we calculated the extent of ?2-PI incorporation by measuring ?2-PI antigen levels from plasma and serum obtained after clotting the plasma by thrombin and Ca2+. The modifying effect of FXIII was studied by spiking of FXIII-A-deficient plasma with purified plasma FXIII. Fibrinogen, FXIII, ?2-PI incorporation, in vitro clot-lysis, soluble fibroblast activation protein and ?2-PI p.Arg6Trp polymorphism were measured from samples of 57 acute ischemic stroke patients obtained before thrombolysis and of 26 healthy controls. Increasing FXIII levels even at levels above the upper limit of normal increased ?2-PI incorporation into the fibrin clot. ?2-PI incorporation of controls and patients with good outcomes did not differ significantly (49.4 ? 4.6% vs. 47.4 ? 6.7%, p = 1.000), however it was significantly lower in patients suffering post-lysis intracranial hemorrhage (37.3 ? 14.0%, p = 0.004). In conclusion, increased FXIII levels resulted in elevated incorporation of ?2-PI into fibrin clots. In stroke patients undergoing intravenous thrombolysis treatment, ?2-PI incorporation shows an association with the outcome of therapy, particularly with thrombolysis-associated intracranial hemorrhage.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Biomolecules. - 11 : 3 (2021), p. 1-13. -
További szerzők:	Baráth Barbara (1991-) (orvosírnok) Orbán-Kálmándi Rita Angéla (1993-) (klinikai laboratóriumi kutató) Szegedi István (1992-) (orvos) Kissné Bogáti Réka (1988-) (tudományos segédmunkatárs) Sarkady Ferenc (1982-) (laboratóriumi analitikus) Csiba László (1952-) (neurológus, pszichiáter) Katona Éva (1961-) (klinikai biokémikus)
Pályázati támogatás:	GINOP-2.2.1-15-2017-00043 GINOP
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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