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001-es BibID:BIBFORM108151
035-os BibID:(cikkazonosító)127 (Scopus)85146818567 (WoS)000916886200001
Első szerző:Somogyi Orsolya (klinikai laboratóriumi kutató)
Cím:New Data on the Features of Skin Barrier in Hidradenitis Suppurativa / Somogyi Orsolya, Dajnoki Zsolt, Szabó Lilla, Gáspár Krisztián, Hendrik Zoltán, Zouboulis Christos C., Dócs Klaudia, Szücs Péter, Dull Katalin, Törőcsik Dániel, Kapitány Anikó, Szegedi Andrea
Dátum:2023
ISSN:2227-9059
Megjegyzések:Hidradenitis suppurativa (HS) is a Th1/17-driven inflammatory skin disease of the apocrine gland-rich (AGR) skin regions, where keratinocytes seem to be the crucial drivers of the initial pathogenic steps. However, the possible role of permeability barrier alteration in activating keratinocytes during HS development has not been clarified. We compared the major permeability barrier elements of non-lesional HS (HS-NL; n = 10) and lesional HS (HS-L; n = 10) skin with healthy AGR regions (n = 10) via RT-qPCR and immunohistochemistry. Stratum corneum components related to cornified envelope formation, corneocyte desquamation and (corneo)desmosome organization were analyzed along with tight junction molecules and barrier alarmins. The permeability barrier function was also investigated with transepidermal water loss (TEWL) measurements (n = 16). Junction structures were also visualized using confocal microscopy. At the gene level, none of the investigated molecules were significantly altered in HS-NL skin, while 11 molecules changed significantly in HS-L skin versus control. At the protein level, the investigated molecules were similarly expressed in HS-NL and AGR skin. In HS-L skin, only slight changes were detected; however, differences did not show a unidirectional alteration, as KRT1 and KLK5 were detected in decreased levels, and KLK7, KRT6 and DSG1 in increased levels. No significant differences in TEWL or the expression of junction structures were assessed. Our findings suggest that the permeability barrier is not significantly damaged in HS skin and permeability barrier alterations are not the driver factors of keratinocyte activation in this disease.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
desmosome
hidradenitis suppurativa
keratinocyte
permeability barrier
tight junction
Megjelenés:Biomedicines. - 11 : 1 (2023), p. 1-12. -
További szerzők:Dajnoki Zsolt (1985-) (molekuláris biológus) Szabó Lilla (1993-) (molekuláris biológus) Gáspár Krisztián (1974-) (bőrgyógyász) Hendrik Zoltán (1986-) (orvos) Zouboulis, Christos C. (1960-) (bőrgyógyász) Dócs Klaudia (1989-) (orvos) Szűcs Péter (1974-) (kutatóorvos) Dull Katalin (1983-) (molekuláris biológus, genetikus) Töröcsik Dániel (1979-) (bőrgyógyász) Kapitány Anikó (1979-) (molekuláris biológus) Szegedi Andrea (1964-) (bőrgyógyász)
Pályázati támogatás:K 128250
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