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001-es BibID:	BIBFORM095575
035-os BibID:	(WoS)000683012200001 (Scopus)85112145519 (PubMed)34381336
Első szerző:	Bayasgalan, Tsogbadrakh (Általános orvos)
Cím:	Alteration of mesopontine cholinergic function by the lack of KCNQ4 subunit / Bayasgalan T., Stupniki S., Kovács A., Csemer A., Szentesi P., Pocsai K., Dionisio L., Spitzmaul G., Pál B.
Dátum:	2021
ISSN:	1662-5102
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Frontiers in Cellular Neuroscience. - 15 (2021), p. 707789. -
További szerzők:	Stupniki, S. Kovács Adrienn (1989-) (molekuláris biológus) Csemer Andrea (1994-) (molekuláris biológus) Szentesi Péter (1967-) (élettanász) Pocsai Krisztina (1978-) (élettanász) Dionisio, L. Spitzmaul, G. Pál Balázs (1975-) (élettanász)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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001-es BibID:	BIBFORM082078
035-os BibID:	(WoS)000509325000003 (Scopus)85071744080 (PubMed)31469725
Első szerző:	Kovács Adrienn (molekuláris biológus)
Cím:	Orexinergic actions modify occurrence of slow inward currents on neurons in the pedunculopontine nucleus / Kovács Adrienn, Baksa Brigitta, Bayasgalan Tsogbadrakh, Szentesi Péter, Csemer Andrea, Pál Balázs
Dátum:	2019
ISSN:	0959-4965
Megjegyzések:	Orexins are neuromodulatory peptides of the lateral hypothalamus which regulate homeostatic mechanisms including sleep-wakefulness cycles. Orexinergic actions stabilize wakefulness by acting on the nuclei of the reticular activating system, including the pedunculopontine nucleus. Orexin application to pedunculopontine neurons produces a noisy tonic inward current and an increase in the frequency and amplitudes of excitatory postsynaptic currents. In the present project, we investigated orexinergic neuromodulatory actions on astrocyte-mediated neuronal slow inward currents of pedunculopontine neurons and their relationships with tonic currents by using slice electrophysiology on preparations from mice. We demonstrated that, in contrast to several other neuromodulatory actions and in line with literature data, orexin predominantly elicited a tonic inward current. A subpopulation of the pedunculopontine neurons possessed slow inward currents. Independently from the tonic currents, actions on slow inward currents were also detected, which resembled other neuromodulatory actions: if slow inward currents were almost absent on the neuron, orexin induced an increase of the charge movements by slow inward currents, whereas if slow inward current activity was abundant on the neurons, orexin exerted inhibitory action on it. Our data support the previous findings that orexin elicits only inward currents in contrast with cannabinoid, cholinergic or serotonergic actions. Similar to the aforementioned neuromodulatory actions, orexin influences slow inward currents in a way depending on control slow inward current activity. Furthermore, we found that orexinergic actions on slow inward currents are similarly independent from its actions on tonic currents, as it was previously found with other neuromodulatory agonists.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk neuromodulation orexin pedunculopontine nucleus slow inward current tonic inward current
Megjelenés:	Neuroreport. - 30 : 14 (2019), p. 933-938. -
További szerzők:	Baksa Brigitta (1989-) (fogorvos) Bayasgalan, Tsogbadrakh (1983-) (Általános orvos) Szentesi Péter (1967-) (élettanász) Csemer Andrea (1994-) (molekuláris biológus) Pál Balázs (1975-) (élettanász)
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001-es BibID:	BIBFORM130038
Első szerző:	Maamrah, Baneen (molekuláris biológus)
Cím:	Chronic Chemogenetic Activation of Astrocytes in the Murine Mesopontine Region Leads to Disturbances in Circadian Activity and Movement / Maamrah Baneen, Pocsai Krisztina, Hoang Bui Minh, Abdelhadi Ali, Al-Khafaji Mustafa Qais, Csemer Andrea, Sokvári Cintia, Szentesi Péter, Pál Balázs
Dátum:	2025
ISSN:	1661-6596 1422-0067
Megjegyzések:	We have previously shown that neuromodulatory actions on astrocytes can elicit metabotropic glutamate- and N-methyl-D-aspartate receptor-dependent tonic changes in excitability in the mesopontine region. Although in vitro experiments explored robust effects, the in vivo significance of our findings remained unknown. In this project, chronic chemogenetic activation of mesopontine astrocytes and its actions on movement, circadian activity, acoustic startle and spatial memory were tested. The control group of young adult male mice where mesopontine astrocytes expressed only the mCherry fluorescent tag was compared to the group expressing the hM3D(Gq) chemogenetic actuator. Chronic chemogenetic astrocyte activation reduced the amplitude of the acoustic startle reflex and increased the locomotion speed in the resting period. Gait alterations were also demonstrated but no change in the spatial memory was explored. As a potential background of these findings, chronic astrocytic activation decreased the cholinergic neuronal number to 54% and reduced the non-cholinergic neuronal number to 76% of the control. In conclusion, chronic astrocytic activation and the consequential decrease in the neuronal number led to disturbances in movement and circadian activity resembling brainstem-related symptoms of progressive supranuclear palsy, raising the possibility that astrocytic overactivation is involved in the pathogenesis of this disease.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk astrocyte pedunculopontine nucleus mesopontine region chemogenetics acoustic startle activity cycles gait spatial memory
Megjelenés:	International Journal Of Molecular Sciences. - 26 : 10 (2025), p. 1-21. -
További szerzők:	Pocsai Krisztina (1978-) (élettanász) Hoang, Bui Minh Abdelhadi, Ali Al-Khafaji, Mustafa Qais Muhsin Csemer Andrea (1994-) (molekuláris biológus) Sokvári Cintia (1995-) Szentesi Péter (1967-) (élettanász) Pál Balázs (1975-) (élettanász)
Pályázati támogatás:	K146873 OTKA Stipendium Hungaricum PhD program Egyéb
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