Találati lista | Tudóstér

001-es BibID:	BIBFORM100001
035-os BibID:	(cikkazonosító)739 (Scopus)85123104849 (WOS)000742753500034
Első szerző:	Gecse Kinga
Cím:	Association of plasma tryptophan concentration with periaqueductal gray matter functional connectivity in migraine patients / Gecse Kinga, Dobos Dóra, Aranyi Csaba Sándor, Galambos Attila, Baksa Daniel, Kocsel Natália, Szabó Edina, Pap Dorottya, Virág Dávid, Ludányi Krisztina, Kökönyei Gyöngyi, Emri Miklós, Bagdy Gyorgy, Juhasz Gabriella
Dátum:	2022
ISSN:	2045-2322
Megjegyzések:	Altered periaqueductal gray matter (PAG) functional connectivity contributes to brain hyperexcitability in migraine. Although tryptophan modulates neurotransmission in PAG projections through its metabolic pathways, the effect of plasma tryptophan on PAG functional connectivity (PAG-FC) in migraine has not been investigated yet. In this study, using a matched case-control design PAG-FC was measured during a resting-state functional magnetic resonance imaging session in migraine without aura patients (n = 27) and healthy controls (n = 27), and its relationship with plasma tryptophan concentration (TRP) was assessed. In addition, correlations of PAG-FC with age at migraine onset, migraine frequency, trait-anxiety and depressive symptoms were tested and the effect of TRP on these correlations was explored. Our results demonstrated that migraineurs had higher TRP compared to controls. In addition, altered PAG-FC in regions responsible for fear-cascade and pain modulation correlated with TRP only in migraineurs. There was no significant correlation in controls. It suggests increased sensitivity to TRP in migraine patients compared to controls. Trait-anxiety and depressive symptoms correlated with PAG-FC in migraine patients, and these correlations were modulated by TRP in regions responsible for emotional aspects of pain processing, but TRP did not interfere with processes that contribute to migraine attack generation or attack frequency.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk migrén funkcionális konnektivitás
Megjelenés:	Scientific Reports. - 12 : 1 (2022), p. 1-12. -
További szerzők:	Dobos Dóra Aranyi Sándor Csaba (1988-) (programtervező informatikus) Galambos Attila Baksa Dániel Kocsel Natália Szabó Edina Pap Dorottya Virág Dávid Ludányi Krisztina (1976-) (gyógyszerész) Kökönyei Gyöngyi Emri Miklós (1962-) (fizikus) Bagdy György Juhász Gabriella
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:

001-es BibID:	BIBFORM098972
035-os BibID:	(cikkazonosító)767162
Első szerző:	Gecse Kinga
Cím:	Sex Differences of Periaqueductal Grey Matter Functional Connectivity in Migraine / Gecse Kinga, Baksa Daniel, Dobos Dóra, Aranyi Csaba Sandor, Galambos Attila, Kocsel Natália, Szabó Edina, Kökönyei Gyöngyi, Emri Miklós, Bagdy Gyorgy, Juhasz Gabriella
Dátum:	2021
ISSN:	2673-561X
Megjegyzések:	The existence of "sex phenotype" in migraine is a long-standing scientific question. Fluctuations of female sex hormones contribute to migraine attacks, and women also have enhanced brain activity during emotional processing and their functional brain networks seem to be more vulnerable to migraine-induced disruption compared to men. Periaqueductal grey matter (PAG) is a core region of pain processing and modulation networks with possible sex-related implications in migraine. In our study, sex differences of PAG functional resting-state connectivity were investigated in the interictal state in 32 episodic migraines without aura patients (16 women and 16 men). A significant main effect of sex was detected in PAG connectivity with postcentral, precentral, and inferior parietal gyri, and further differences were found between right PAG and visual areas (superior occipital gyrus, calcarine, and cuneus), supplementary motor area, and mid-cingulum connectivity. In all cases, PAG functional connectivity was stronger in female migraineurs compared to males. However, higher average pain intensity of migraine attacks correlated with stronger connectivity of PAG and middle temporal, superior occipital, and parietal gyri in male migraineurs compared to females. igrainerelated disability is also associated with PAG connectivity but without sex differences. Our results indicate that sex differences in PAG connectivity with brain regions involved in sensory and emotional aspects of pain might contribute to the "sex-phenotype" in migraine. The stronger functional connectivity between PAG and pain processing areas may be a sign of increased excitability of pain pathways even in resting-state in females compared to male migraineurs, which could contribute to female vulnerability for migraine. However, pain intensity experienced by male migraineurs correlated with increased connectivity between PAG and regions involved in the subjective experience of pain and pain-related unpleasantness. The demonstrated sex differences of PAG functional connectivitymay support the notion that the female andmale brain is differently affected by migraine.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk headache periaqueductal gray pain intensity disability
Megjelenés:	Frontiers in Pain Research. - 2 (2021), p. 1-9. -
További szerzők:	Baksa Dániel Dobos Dóra Aranyi Sándor Csaba (1988-) (programtervező informatikus) Galambos Attila Kocsel Natália Szabó Edina Kökönyei Gyöngyi Emri Miklós (1962-) (fizikus) Bagdy György Juhász Gabriella
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: