CCL

Összesen 1 találat.
#/oldal:
Részletezés:
Rendezés:

1.

001-es BibID:BIBFORM096580
035-os BibID:(cikkazonosító)2409 (WoS)000676356300001 (Scopus)85109904667
Első szerző:Kovács Elek Gergő
Cím:Caffeine Has Different Immunomodulatory Effect on the Cytokine Expression and NLRP3 Inflammasome Function in Various Human Macrophage Subpopulations / Elek Gergő Kovács, Ahmad Alatshan, Marietta Margit Budai, Zsolt Czimmerer, Eduárd Bíró, Szilvia Benkő
Dátum:2021
ISSN:2072-6643
Megjegyzések:Besides its well-known psychoactive effects, caffeine has a broad range of actions. It regulates several physiological mechanisms as well as modulates both native and adaptive immune responses by various ways. Although caffeine is assumed to be a negative regulator of inflammation, the effect on the secretion of pro- and anti-inflammatory cytokines is highly controversial. Macrophages are major mediators of inflammatory responses; however, the various subpopulations develop different effects ranging from the initiation to the resolution of inflammation. Here we report a comparative analysis of the effect of caffeine on two subpopulations of human monocyte-derived macrophages differentiated in the presence of macrophage colony-stimulating factor (M-CSF) or granulocyte-macrophage colony-stimulating factor (GM-CSF), resulting in M-M?s and GM-M?s, respectively. We showed that although TNF-? secretion was downregulated in both LPS-activated M? subtypes by caffeine, the secretion of IL-8, IL-6, and IL-1? as well as the expression of Nod-like receptors was enhanced in M-M?s, while it did not change in GM-M?s. We showed that caffeine (1) altered adenosine receptor expression, (2) changed Akt/AMPK/mTOR signaling pathways, and (3) inhibited STAT1/IL-10 signaling axis in M-M?s. We hypothesized that these alterations play an important modulatory role in the upregulation of NLRP3 inflammasome-mediated IL-1? secretion in LPS-activated M-M?s following caffeine treatment.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
caffeine
inflammation
macrophages
NLRP3 inflammasome
cytokines
signaling
Megjelenés:Nutrients. - 13 : 7 (2021), p. 2409. -
További szerzők:Alatshan, Ahmad (1984-) (immunológus) Budai Marietta Margit (1985-) (molekuláris biológus) Czimmerer Zsolt (1981-) (molekuláris biológus) Bíró Eduárd (1998-) (molekuláris biológus) Benkő Szilvia (1973-) (molekuláris biológus)
Pályázati támogatás:K131844
OTKA
FK132185
OTKA
GINOP-2.3.2-15-2016-00040
GINOP
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Rekordok letöltése1