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001-es BibID:BIBFORM103904
Első szerző:Lőrincz Hajnalka (biológus)
Cím:Plasminogen activator inhibitor-1 level associated with the components of metabolic syndrome in a 4G/5G polymorphism dependent manner / Lőrincz H., Galgóczy E., Katkó M., Ratku B., Ötvös T., Harangi M., Paragh G., Szabó Z., Somodi S.
Megjegyzések:Background and Aims : The elevated level of plasminogen activator inhibitor- 1 (PAI-1) in obese subjects with metabolic syndrome and in patients with type 2 diabetes is well established. A common 4G/5G single guanine insertion/deletion polymorphism in the promoter region of the PAI-1 gene is of functional importance in regulating PAI-1 expression. We aimed to study the potential different correlations of carbohydrate and lipid parameters and plasma PAI-1 levels in the 4G and 5G carriers in obese and lean subjects. Methods: Ninety-three morbid obese and thirty-two lean non-diabetic participants were enrolled. PAI-1 4G/5G polymorphism was determined with allele-specific PCR. Plasma PAI-1 levels were measured by ELISA. Results: The genotype distribution of PAI-1 4G/5G polymorphism was not significantly differed in obese patients (4G/4G 27.9%; 4G/5G 45.2% and 5G/ 5G 26.9%) compared to controls (4G/4G 31.3%; 4G/5G 46.9% and 5G/5G 21.9%, p?0.8). Slightly higher PAI-1 levels were found in 4G carriers (4G/ 4G+4G/5G) in obese and control group (p?0.07 and p?0.02, respectively). In all subjects with 4G/5G genotype, plasma PAI-1 correlated negatively with high-density lipoprotein-cholesterol (HDL-C) (p?0.02) and apolipoprotein AI (apoAI) levels (p<0.001). In 5G/5G participants, PAI-1 also correlated negatively with HDL-C (p?0.025) and apoAI (p?0.007) concentrations, moreover positively with triglyceride (p?0.02), fasting glucose (p?0.002) and haemoglobin A1c (p?0.027). These correlations are lacking in 4G/4G participants. Conclusions: The observed correlations between PAI-1 levels and the components of metabolic syndrome suggest a closer link between PAI-1 and lipid and carbohydrate metabolism in subjects with 5G/5G genotype. This presentation was supported by the Bridging Fund (Faculty of Medicine, University of Debrecen) and PD124126 project.
Tárgyszavak:Orvostudományok Egészségtudományok idézhető absztrakt
Plasminogen activator inhibitor-1
promoter polymorphism
lipid metabolism
Megjelenés:Atherosclerosis. - 355 (2022), p. e248. -
További szerzők:Galgóczi Erika (1986-) (biológus) Katkó Mónika (1980-) (biológus) Ratku Balázs (1985-) (mentőtiszt) Ötvös Tamás (1980-) (orvos) Harangi Mariann (1974-) (belgyógyász, endokrinológus) Paragh György (1953-) (belgyógyász) Szabó Zoltán (1973-) (belgyógyász, kardiológus) Somodi Sándor (1977-) (belgyógyász)
Pályázati támogatás:PD124126
Internet cím:Szerző által megadott URL
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001-es BibID:BIBFORM095124
035-os BibID:(cikkazonosító)614493
Első szerző:Ujvárosy Dóra
Cím:Cardiopulmonary Resuscitation With Mechanical Chest Compression Device During Percutaneous Coronary Intervention : a case report / Dóra Ujvárosy, Veronika Sebestyén, Tamás Ötvös, Balázs Ratku, István Lorincz, Tibor Szuk, Zoltán Csanádi, Ervin Berényi, Zoltán Szabó
Megjegyzések:Sudden cardiac death is a leading cause of death worldwide, whereby myocardial infarction is considered the most frequent underlying condition. Percutaneous coronary intervention (PCI) is an important component of post-resuscitation care, while uninterrupted high-quality chest compressions are key determinants in cardiopulmonary resuscitation (CPR). In our paper, we evaluate a case of a female patient who suffered aborted cardiac arrest due to myocardial infarction. The ambulance crew providing prehospital care for sudden cardiac arrest used a mechanical chest compression device during advanced CPR, which enabled them to deliver ongoing resuscitation during transfer to the PCI laboratory located 20 km away from the scene. Mechanical chest compressions were continued during the primary coronary intervention. The resuscitation, carried out for 2 h and 35 min, and the coronary intervention were successful, as evidenced by the return of spontaneous circulation and by the fact that, after a short rehabilitation, the patient was discharged home with a favorable neurological outcome. Our case can serve as an example for the effective and safe use of a mechanical compression device during primary coronary intervention.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
sudden cardiac death
cardiopulmonary resuscitation
coronary intervention
mechanical chest compression device
Megjelenés:Frontiers in Cardiovascular Medicine. - 8 (2021), p. 1-6. -
További szerzők:Borbásné Sebestyén Veronika (1990-) (biofizikus) Ötvös Tamás (1980-) (orvos) Ratku Balázs (1985-) (mentőtiszt) Lőrincz István (1950-) (belgyógyász, kardiológus) Szűk Tibor (1967-) (kardiológus) Csanádi Zoltán (1960-) (kardiológus) Berényi Ervin (1964-) (radiológus) Szabó Zoltán (1973-) (belgyógyász, kardiológus)
Pályázati támogatás:GINOP-2.3.2-15-2016-00005
Internet cím:Szerző által megadott URL
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