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001-es BibID:BIBFORM113766
035-os BibID:(WoS)001056767900001 (Scopus)85169115288
Első szerző:Nokhoijav, Erdenetsetseg (kutatóorvos)
Cím:Comparative Analysis of Amino Acid and Biogenic Amine Compositions of Fermented Grape Beverages / Erdenetsetseg Nokhoijav, Andrea Guba, Uladzislau Vadadokhau, József Tőzsér, Zoltán Győri, Gergő Kalló, Éva Csősz
Dátum:2023
ISSN:2218-1989
Megjegyzések:Amino acids and biogenic amines are important components of food and beverages. In grape-derived products such as wine and wine vinegar, they can have different origins and can influence the odor and taste of the products. Their concentration is influenced by the grape variety, vintage, and winemaking process. In our study, we carried out an LC-MS-based comparative analysis of 22 grape-derived beverages, including three different wine types and four wine vinegar samples from the Tokaj region in Hungary. The concentrations of 23 amino acids and 10 biogenic amines were examined, and the differences among the sample types were analyzed. The differences in the concentrations of some metabolites between Aszú?Furmint pairs originating from the same wineries and year provide information on the effect of botrytized grape on wine composition. Our data can provide further evidence on how the production process shapes the metabolite content of beverages and highlight the nutritional value of wine vinegar
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
amino acid
biogenic amine
wine
wine vinegar
LC-MS
Megjelenés:Metabolites. - 13 : 8 (2023), p. 1-13. -
További szerzők:Guba Andrea (1975-) (Okleveles vegyész) Vadadokhau, Uladzislau (1995-) Tőzsér József (1959-) (molekuláris biológus, biokémikus, vegyész) Győri Zoltán (1948-) (vegyész) Kalló Gergő (1989-) (molekuláris biológus) Csősz Éva (1977-) (biokémikus, molekuláris biológus)
Pályázati támogatás:GINOP-2.3.3-15-2016-00020
GINOP
GINOP-2.3.4-15-2016-00002
GINOP
Internet cím:DOI
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001-es BibID:BIBFORM122639
035-os BibID:(Scopus)85192746584 (WOS)001219973300001
Első szerző:Vadadokhau, Uladzislau
Cím:Examination of the Complex Molecular Landscape in Obesity and Type 2 Diabetes / Uladzislau Vadadokhau, Imre Varga, Miklós Káplár, Miklós Emri, Éva Csősz
Dátum:2024
ISSN:1661-6596 1422-0067
Megjegyzések:The escalating prevalence of metabolic disorders, notably type 2 diabetes (T2D) and obesity, presents a critical global health challenge, necessitating deeper insights into their molecular underpinnings. Our study integrates proteomics and metabolomics analyses to delineate the complex molecular landscapes associated with T2D and obesity. Leveraging data from 130 subjects, including individuals with T2D and obesity as well as healthy controls, we elucidate distinct molecular signatures and identify novel biomarkers indicative of disease progression. Our comprehensive characterization of cardiometabolic proteins and serum metabolites unveils intricate networks of biomolecular interactions and highlights differential protein expression patterns between T2D and obesity cohorts. Pathway enrichment analyses reveal unique mechanisms underlying disease development and progression, while correlation analyses elucidate the interplay between proteomics, metabolomics, and clinical parameters. Furthermore, network analyses underscore the interconnectedness of cardiometabolic proteins and provide insights into their roles in disease pathogenesis. Our findings may help to refine diagnostic strategies and inform the development of personalized interventions, heralding a new era in precision medicine and healthcare innovation. Through the integration of multi-omics approaches and advanced analytics, our study offers a crucial framework for deciphering the intricate molecular underpinnings of metabolic disorders and paving the way for transformative therapeutic strategies. ? 2024 by the authors.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
data integration
metabolomics
obesity
proteomics
type 2 diabetes
Megjelenés:International Journal Of Molecular Sciences. - 25 : 9 (2024), p. 1-13. -
További szerzők:Varga Imre (1979-) (fizikus, informatikus) Káplár Miklós (1965-) (belgyógyász, diabetológus) Emri Miklós (1962-) (fizikus) Csősz Éva (1977-) (biokémikus, molekuláris biológus)
Internet cím:Szerző által megadott URL
DOI
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