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001-es BibID:	BIBFORM070391
035-os BibID:	(Scopus)85013468469 (WOS)000408987300003
Első szerző:	Kovács Zsuzsanna
Cím:	Capillary electrophoresis analysis of N-glycosylation changes of serum paraproteins in multiple myeloma / Zsuzsanna Kovacs, Adam Simon, Zoltan Szabo, Zsolt Nagy, Laszlo Varoczy, Ildiko Pal, Eszter Csanky, Andras Guttman
Dátum:	2017
ISSN:	0173-0835
Megjegyzések:	AbstractMultiple myeloma (MM) is an immedicable malignancy of the human plasma cells producing abnormal antibodies (also referred to as paraproteins) leading to kidney problems and hyperviscosity syndrome. In this paper, we report on the N-glycosylation analysis of paraproteins from total human serum as well as the fragment crystallizable region (Fc) and fragment antigen binding (Fab) ?/? light chain fractions of papain digested immunoglobulins from multiple myeloma patients. CE-LIF detection was used for the analysis of the N-glycans after endoglycosidase (PNGase F) mediated sugar release and fluorophore labeling (APTS). While characteristic N-glycosylation pattern differences were found between normal control and untreated, treated and remission stage multiple myeloma patient samples at the global serum level, less distinctive changes were observed at the immunoglobulin level. Principal component analysis adequately differentiated the four groups (control and three patient groups) on the basis of total serum N-glycosylation analysis. 12 N-glycan features showed statistically significant differences (p <0.05) among various stages of the disease in comparison to the control at the serum level, while only six features were identified with similar significance at the immunoglobulin level, including the analysis of the partitioned Fc fragment as well as the Fab? and Fab? chains.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk electrophoresis
Megjelenés:	Electrophoresis. - 38 : 17 (2017), p. 2115-2123. -
További szerzők:	Simon Ádám (1990-) (molekuláris biológus) Szabó Zoltán Nagy Zsolt Váróczy László (1974-) (belgyógyász, haematológus) Pál Ildikó (1989-) (belgyógyász szakorvos) Csánky Eszter (1959-) (tüdőgyógyász, klinikai immunológus, allergológus) Guttman András (1954-) (vegyészmérnök)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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