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001-es BibID:	BIBFORM027587
Első szerző:	Kónya József (szakorvos, klinikai mikrobiológus)
Cím:	Correlation of human papillomavirus 16 and 18 with prognostic factors in invasive cervical neoplasias / Kónya J., Veress G., Hernádi Z., Soós G., Czeglédy J., Gergely L.
Dátum:	1995
ISSN:	0146-6615
Megjegyzések:	Forty-seven patients with cervical carcinoma were examined in order to correlate human papillomavirus (HPV) types with prognostic factors in invasive cervical neoplasias. Age, clinical stage, histological type, and grade and parity were analysed with respect to HPV status as determined by a general primer mediated polymerase chain reaction (PCR) or a type specific PCR. All but one sample (98%) harboured HPV sequences: HPV 16 was found in 26 cases (55%), HPV 18 in 19 cases (40%), and HPV 31 in 1 case. The presence of HPV 18 DNA was significantly associated with cancers developed below 40 years of age (P = 0.029). HPV 18 detection was associated with poor differentiation malignancy (P = 0.045) and histological types of poor prognosis (adenocarcinoma or nondifferentiated carcinoma; P = 0.006). HPV 18 positivity was also correlated with advanced clinical stages (FIGO II and III; P = 0.032). Parity and HPV status proved to be independent of each other (P approximately 0.99). Eighty-seven percent (27/31) of pelvic lymph nodes from HPV positive patients contained HPV DNA. The virus types found in lymph nodes were identical with those of the primary tumours in all cases. Virological results were compared to those obtained by routine histological examination. Only 6 of 27 patients with HPV positive lymph nodes had any histological evidence of metastasis. Nevertheless, the lack of metastasis as detected by histology does not exclude the possibility of relapses. Follow-up of the clinical prognostic significance of PCR detection of HPV in the possible sites of early metastases.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Journal Of Medical Virology. - 46 : 1 (1995), p. 1-6. -
További szerzők:	Veress György (1966-) (biológus, mikrobiológus) Hernádi Zoltán (1948-) (szülész-nőgyógyász, klinikai onkológus) Soós Györgyike (1959-) (pathológus) Czeglédy Judit (1944-) (virológus) Gergely Lajos (1940-) (szakorvos, klinikai mikrobiológus)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM031241
Első szerző:	Major Tamás (fül-orr-gégész)
Cím:	A juvenilis gégepapillomatosis virológiai vonatkozásai / Major Tamás, Jókay István, Soós Györgyike, Gergely Lajos, Czeglédy Judit
Dátum:	1999
Megjegyzések:	Juvenile laryngeal papillomatosis is the most common benign tumor of the larynx in childhood. The specific etiological factors are non-oncogenic human papillomavirus types 6 and 11. In the present study two cases (a 6-year-old male and a 5 and a half-year-old female) operated five times each and harbouring type 11 DNA i papillomas excised in the first operations are analysed from the following virological aspects: 1. the examination of vertical transmission by general primer-polymerase chain reaction of maternal cervical exfoliation; 2. sites of papilloma predilections in the larynx; 3. histopathology; 4. viral DNA detection from the formalin-fixed and paraffin-embedded archive tissues and from a fresh papilloma tissue in one case by polymerase chain reaction applying type-specific primers. We did not find any signs of maternofoetal transmission in the anamnesis and the maternal cervix proved to be negative for viral DNA. However, the vertical route of transmission can not be excluded due to the special natural history of papillomavirus infections. Papillomas usually localised in normal squamociliary junctions of the larynx. The histopathologic review did not reveal any signs of malignancy. Koilocytosis referring to productive viral infection and the signs of abnormal keratinisation were present in each tissue. All tissues of the patients proved to be positive for the short amplimer deriving from the genom of human papillomavirus type 11.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok magyar nyelvű folyóiratközlemény hazai lapban egyetemen (Magyarországon) készült közlemény
Megjelenés:	Orvosi Hetilap. - 140 : 8 (1999), p. 405-409. -
További szerzők:	Jókay István (1954-) (fül-orr-gégész) Soós Györgyike (1959-) (pathológus) Gergely Lajos (1940-) (szakorvos, klinikai mikrobiológus) Czeglédy Judit (1944-) (virológus)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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