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001-es BibID:	BIBFORM040735
Első szerző:	Jenei Zoltán (belgyógyász)
Cím:	Anthracycline causes impaired vascular endothelial function and aortic stiffnes in long term survivors of childhood cancer / Zoltán Jenei, Edit Bárdi, Mária Tünde Magyar, Ágnes Horváth, György Paragh, Csongor Kiss
Dátum:	2013
ISSN:	1532-2807
Megjegyzések:	Vascular and endothelial functions were investigated in long term survivors of childhood cancer exposed to anthracycline treatment. We enrolled 96 long-term survivors (57 males and 39 females, mean age 14.9±5.3 year) of different childhood cancers and 72 age-, sex-, bodyweight- and blood pressure matched controls (39 males and 33 females, mean age 13.7±4.9 year). Aortic stiffness was characterized by echocardiography. Brachial artery endothelial function was assessed by flow-mediated dilatation (FMD%) and nitrate-mediated dilatation (NTG%). Results were compared between three subgroups: anthracycline treated, only chemotherapy treated and control subgroups. The cumulative anthracycline dose was less than 350 mg/m(2). The healthy control subgroup had a significantly greater FMD response (13.13±2.40 %), and lower stiffness index (2.08±0.6) than both the anthracycline (7.12±6.28 % and 6.45±3.25, respectively) and only chemotherapy treated (10.17±4.23 % and 4.12±2.32, respectively) subgroups. In the anthracycline treated subgroup a significantly (p<0.01) lower FMD% response, and higher stiffness index were detected than in the only chemotherapy treated subgroup. Higher triglyceride level, higher cumulative anthracycline dose and lower age at the start of treatment were found to be associated independently with impairment of FMD% response and aortic stiffness. We found a significant negative correlation between FMD and aortic stiffness (p<0.001) and a positive correlation between FMD and distensibility (p<0.0001) Childhood cancer long term survivors exposed to anthracycline treatment exhibit a marked preclinical vasculopathy, characterized by endothelial dysfunction and increased arterial stiffness, contributing to a deteriorated cardiovascular function.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Egészség- és Környezettudomány
Megjelenés:	Pathology & Oncology Research. - 19 : 3 (2013), p. 375-383. -
További szerzők:	Bárdi Edit (1971-) (csecsemő- és gyermekgyógyász) Magyar Mária Tünde (1970-) (neurológus) Horváth Ágnes (1985-) (reumatológus) Paragh György (1953-) (belgyógyász) Kiss Csongor (1956-) (hematológus, onkológus)
Pályázati támogatás:	ETT 396/2006 Egyéb 01-478/2009 Egyéb TÁMOP-4.2.1/B-09/1/KONV-2010-0007 TÁMOP Rosszindulatú daganatos megbetegedések serdülő és fiatal felnőttkorban
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat Szerző által megadott URL DOI
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