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001-es BibID:	BIBFORM023036
Első szerző:	Magyar Mária Tünde (neurológus)
Cím:	Early-onset carotid atherosclerosis is associated with increased intima-media thickness and elevated serum levels of inflammatory markers / Magyar M. T., Szikszai Z., Balla J., Valikovics A., Kappelmayer J., Imre S., Balla G., Jeney V., Csiba L., Bereczki D.
Dátum:	2003
ISSN:	0039-2499
Megjegyzések:	Background and Purpose-Several factors have been held responsible for the development of atherosclerosis. To avoid the masking effect of age, we evaluated correlates of carotid atherosclerosis in patients <55 years of age..Methods-Plasma lipids, oxidative resistance of low-density lipoprotein, homocysteine, inflammatory markers, plasma viscosity, and red cell deformability were measured in fasting blood samples of 100 subjects: 45 patients with >30% stenosis of the internal carotid artery, 20 patients with carotid occlusion, and 35 control subjects. Stenosis and intima-media thickness (IMT) of the carotid artery were evaluated by duplex ultrasound.Results-White blood cell (WBC) count, plasma fibrinogen, C-reactive protein (CRP), and lipoprotein(a) levels were significantly higher in patients than in control subjects, and patients had increased IMT (P<0.01 for all comparisons). There was a tendency for higher homocysteine levels in patients. Smokers had higher WBC, fibrinogen, and CRP levels. After the effect of smoking was controlled for, WBC count, natural logarithmic transform of homocysteine, and online-measured IMT remained significantly higher in patients than in control subjects. WBC, fibrinogen, and CRP levels were highest in the highest IMT quartile (P=0.012, P=0.007, and P=0.036, respectively).Conclusions-Inflammatory markers and homocysteine have a more important role than lipid factors in early-onset carotid atherosclerosis. We cannot recommend the measurement of low-density lipoprotein peroxidation as a routine screening test to identify high-risk patients for early-onset carotid atherosclerosis. The confounding effect of smoking on inflammatory markers should be considered in studies on atherosclerosis.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Stroke. - 34 : 1 (2003), p. 58-63. -
További szerzők:	Szikszai Zita (1969-) (fizikus) Balla József (1959-) (belgyógyász, nephrológus) Valikovics Attila Kappelmayer János (1960-) (laboratóriumi szakorvos) Imre Sándor (1941-) (pathofiziológus) Balla György (1953-) (csecsemő és gyermekgyógyász, neonatológus) Jeney Viktória (1971-) (vegyész, kémia tanár) Csiba László (1952-) (neurológus, pszichiáter) Bereczki Dániel (1960-) (neurológus)
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001-es BibID:	BIBFORM001488
Első szerző:	Magyar Mária Tünde (neurológus)
Cím:	Calcium distribution in the vessel wall and intima-media thickness of the human carotid arteries / Magyar Mária Tünde, Szikszai Zita, Kertész Zsófia, Molnár Sándor, Uzonyi Imre, Szíki Gusztáv Áron, Csiba László
Dátum:	2007
Megjegyzések:	Abstract-Increased common carotid artery (CCA) intima-media thickness (IMT) measured by B-mode ultrasound is an early marker of the atherosclerotic process. Arterial calcification is not clearly understood. Using the particle-induced X-ray emission (PIXE) method, we have looked for the location in the artery wall where calcium accumulated in the early phase of atherosclerosis. Twelve segments of CCAs of deceased stroke patients were investigated. In-vivo, carotid duplex ultrasound was performed with bilateral CCA IMT measurement at plaque-free sections. During autopsy, segments of carotid arteries were collected and filled under pressure with a stained histologic embedding material. The frozen arteries were cut into 60-m-thick slices. Calcium distribution maps from the segments of arteries were determined by PIXE method. IMT measured by ultrasound and calcium distribution maps measured by PIXE were compared. In our cross-sectional study, using the PIXE analysis and ultrasound images, we could demonstrate early calcium accumulation in the media layer. Our results have also shown a significant relationship between calcium content of distributional maps measured by PIXE analysis and corresponding IMT on B-mode ultrasound images of human CCAs.
Tárgyszavak:	Orvostudományok Természettudományok Klinikai orvostudományok Fizikai tudományok idegen nyelvű folyóiratközlemény külföldi lapban Intima-media thickness Calcium accumulation Particle induced X-ray emission
Megjelenés:	Ultrasound in Medicine and Biology. - 33 : 8 (2007), p. 1171-1178. -
További szerzők:	Szikszai Zita (1969-) (fizikus) Kertész Zsófia (1971-) (fizikus) Molnár Sándor (1973-) (neurológus) Uzonyi Imre Szíki Gusztáv Áron (1973-) (fizikus) Csiba László (1952-) (neurológus, pszichiáter)
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001-es BibID:	BIBFORM008785
Első szerző:	Szikszai Zita (fizikus)
Cím:	Regional calcium distribution and ultrasound images of the vessel wall in human carotid arteries / Z. Szikszai, Zs. Kertész, I. Uzonyi, G. Á. Szíki, M. T. Magyar, S. Molnár, Y. Ida, L. Csiba
Dátum:	2005
Megjegyzések:	Arterial calcification can take place at two sites in the vessel wall: the intima and the media. Intimal calcification occurs exclusively within atherosclerotic plaques, while medial calcification may develop independently. Extensive calcified plaques in the carotid arteries can be easily detected by B-mode ultrasonic imaging. The calcium content might correlate with the ultrasound reflectance of the vessel wall, and could be a surrogate marker for arteriosclerosis. In this study, segments of human carotid arteries collected at autopsy were examined by ultrasonography in vitro and calcium distributional maps of sections from the same segments were determined by particle induced X-ray emission. Our aim was to make a first step towards investigating the relationship between the calcium distributional maps and the respective ultrasound images.
Tárgyszavak:	Természettudományok Fizikai tudományok idegen nyelvű folyóiratközlemény külföldi lapban Vascular calcification Carotid artery Nuclear microscopy B-mode ultrasound
Megjelenés:	Nuclear instruments and methods in physics research. Section B: beam interactions with materials and atoms. - 231 : 1-4 (2005), p. 263-267. -
További szerzők:	Kertész Zsófia (1971-) (fizikus) Uzonyi Imre Szíki Gusztáv Áron (1973-) (fizikus) Magyar Mária Tünde (1970-) (neurológus) Molnár Sándor (1973-) (neurológus) Ida, Yaeko Csiba László (1952-) (neurológus, pszichiáter)
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