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001-es BibID:	BIBFORM004803
Első szerző:	Kónya József (szakorvos, klinikai mikrobiológus)
Cím:	Severity of carotid atherosclerosis unrelated to chlamydia pneumoniae infection in acute ischemic stroke patients : a clinicopathological Study / József Kónya, Sándor Molnár, Mária T. Magyar, Csilla C. Szekeres, Levente Kerényi, László Csiba
Dátum:	2008
Megjegyzések:	Both clinical and pathological alterations of the carotid arteries were correlated with Chlamydia pneumoniae infection in 67 acute ischemic stroke patients with severe neurological symptoms. Methods: In the clinical study, intima-media thickness (IMT) of the common carotid arteries was determined in vivo by B-mode ultrasound measurement and C. pneumoniae- specific IgG and IgA responses were detected. In the pathological study, the absolute wall thickness of the common, internal and external carotid arteries was measured postmortem in specimens obtained at the autopsy of patients who died due to complications of acute stroke. In the atherosclerotic plaques of the autopsy specimens, C. pneumoniae genomic DNA was detected by polymerase chain reaction amplification. Results: The Spearman's rho correlation coefficient of IMT with the average wall thickness of the common, internal and external carotid arteries was 0.51 (p = 0.002), 0.34 (p = 0.052) and 0.58 (p ! 0.001), respectively. Anti- C. pneumoniae IgG and IgA anti-bodies were detected in 43 (73%) and 29 (49%) patients, but neither antibody marker correlated with IMT (median: 0.91 mm in IgG positives vs. 0.90 mm in IgG negatives, p = 0.86; 0.88 mm in IgA positives vs. 0.90 mm in IgA negatives, p = 0.53). The presence of C. pneumoniae DNA was detected in the carotid plaques of 21 (54%) of the 39 tested patients, independently of either IMT values or the average wall thickness of all carotid arteries. Conclusions: In acute ischemic stroke patients, C. pneumoniae infection was frequently detected in the arteriosclerotic plaques of the carotid arteries but it did not correlate with the severity of carotid arteriosclerosis.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Chlamydia pneumoniae Carotid arteries carotid ultrasonography Ischemic stroke
Megjelenés:	Cerebrovascular Diseases 25 : 1-2 (2008), p. 170-175. -
További szerzők:	Molnár Sándor (1973-) (neurológus) Magyar Mária Tünde (1970-) (neurológus) Szekeres Csilla Cecília (1980-) (orvos) Kerényi Levente Csiba László (1952-) (neurológus, pszichiáter)
Internet cím:	DOI elektronikus változat
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