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001-es BibID:BIBFORM089637
035-os BibID:(cikkazonosító)1323 (WoS)000552774700001 (Scopus)85087909923
Első szerző:Bozza, Marcelo T.
Cím:Pro-inflammatory Actions of Heme and Other Hemoglobin-Derived DAMPs / Bozza Marcelo T., Jeney Viktória
Dátum:2020
ISSN:1664-3224
Megjegyzések:Damage associated molecular patterns (DAMPs) are endogenous molecules originate from damaged cells and tissues with the ability to trigger and/or modify innate immune responses. Upon hemolysis hemoglobin (Hb) is released from red blood cells (RBCs) to the circulation and give a rise to the production of different Hb redox states and heme which can act as DAMPs. Heme is the best characterized Hb-derived DAMP that targets different immune and non-immune cells. Heme is a chemoattractant, activates the complement system, modulates host defense mechanisms through the activation of innate immune receptors and the heme oxygenase-1/ferritin system, and induces innate immune memory. The contribution of oxidized Hb forms is much less studied, but some evidence show that these species might play distinct roles in intravascular hemolysis-associated pathologies independently of heme release. This review aims to summarize our current knowledge about the formation and pro-inflammatory actions of heme and other Hb-derived DAMPs.
xtaa
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
hemoglobin
heme
TLR4 (toll-like receptor
NLRP3
DAMP
hemolysis (red blood cells)
Megjelenés:Frontiers in Immunology. - 11 (2020), p. 1-13. -
További szerzők:Jeney Viktória (1971-) (vegyész, kémia tanár)
Pályázati támogatás:K131535
NKFIH
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2.

001-es BibID:BIBFORM085388
035-os BibID:(WoS)000524776500001 (Scopus)85082380165 (cikkazonosító)228
Első szerző:Erdei Judit Zsuzsa (vegyész)
Cím:The Role of Hemoglobin Oxidation Products in Triggering Inflammatory Response Upon Intraventricular Hemorrhage in Premature Infants / Erdei Judit, Tóth Andrea, Nagy Andrea, Nyakundi Benard Bogonko, Fejes Zsolt, Nagy Béla Jr., Novák László, Bognár László, Balogh Enikö, Paragh György, Kappelmayer János, Bácsi Attila, Jeney Viktória
Dátum:2020
ISSN:1664-3224
Megjegyzések:Intraventricular hemorrhage (IVH) is a frequent complication of prematurity that is associated with high neonatal mortality and morbidity. IVH is accompanied by red blood cell (RBC) lysis, hemoglobin (Hb) oxidation, and sterile inflammation. Here we investigated whether extracellular Hb, metHb, ferrylHb, and heme contribute to the inflammatory response after IVH. We collected cerebrospinal fluid (CSF) (n = 20) from premature infants with grade III IVH at different time points after the onset of IVH. Levels of Hb, metHb, total heme, and free heme were the highest in CSF samples obtained between days 0 and 20 after the onset of IVH and were mostly non-detectable in CSF collected between days 41 and 60 of post-IVH. Besides Hb monomers, we detected cross-linked Hb dimers and tetramers in post-IVH CSF samples obtained in days 0-20 and 21-40, but only Hb tetramers were present in CSF samples obtained after 41-60 days. Vascular cell adhesion molecule-1 (VCAM-1) and interleukin-8 (IL-8) levels were higher in CSF samples obtained between days 0 and 20 than in CSF collected between days 41 and 60 of post-IVH. Concentrations of VCAM-1, intercellular adhesion molecule-1 (ICAM-1), and IL-8 strongly correlated with total heme levels in CSF. Applying the identified heme sources on human brain microvascular endothelial cells revealed that Hb oxidation products and free heme contribute to the inflammatory response. We concluded that RBC lysis, Hb oxidation, and heme release are important components of the inflammatory response in IVH. Pharmacological interventions targeting cell-free Hb, Hb oxidation products, and free heme could have potential to limit the neuroinflammatory response following IVH.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Frontiers in Immunology. - 11 (2020), p. 228. -
További szerzők:Tóth Andrea (1992-) (molekuláris biológus) Nagy Andrea (1958-) (csecsemő és gyermekgyógyász, neonatológus) Nyakundi, Benard Bogonko (1983-) (biokémikus) Fejes Zsolt (1988-) (molekuláris biológus) Nagy Béla Jr. (1980-) (labordiagnosztikai szakorvos) Novák László (1964-) (idegsebész) Bognár László (1958-) (idegsebész, gyermekidegsebész) Balogh Enikő (1987-) (molekuláris biológus) Paragh György (1953-) (belgyógyász) Kappelmayer János (1960-) (laboratóriumi szakorvos) Bácsi Attila (1967-) (immunológus) Jeney Viktória (1971-) (vegyész, kémia tanár)
Pályázati támogatás:GINOP-2.3.2-15-2016-00005
GINOP
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