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001-es BibID:	BIBFORM049592
035-os BibID:	PMID:23870824
Első szerző:	Kis-Tóth Katalin (immunológus)
Cím:	Monocyte-derived dendritic cell subpopulations use different types of matrix metalloproteinases inhibited by GM6001 / Katalin Kis-Toth, Ildiko Bacskai, Peter Gogolak, Anett Mazlo, Istvan Szatmari, Eva Rajnavolgyi
Dátum:	2013
ISSN:	0171-2985
Megjegyzések:	Matrix metalloproteinases (MMPs) are endopeptidases with the potential to cleave extracellular matrix, support tissue renewal and regulate cell migration. Functional activities of MMPs are regulated by tissue inhibitors of MMPs (TIMPs) and disruption of the MMP-TIMP balance has pathological consequences. Here we studied the expression and secretion of MMPs and TIMPs in CD1a(-) and CD1a(+) monocyte-derived dendritic cell (DC) subpopulations. Our results showed that monocytes express TIMPs but lack MMPs, whereas upon differentiation to moDCs and in response to activation signals the expression of MMPs is increased and that of TIMPs is decreased. MMP-9 is expressed dominantly in the CD1a(-) subpopulation, while MMP-12 is preferentially expressed in CD1a(+) cells. Experiments performed with the synthetic MMP inhibitor GM6001 revealed that this drug efficiently inhibits the migration of moDCs through inactivation of MMPs. We conclude that modulation of MMP activity by GM6001 emerges as a novel approach to manipulate DC migration under inflammatory conditions. (C) 2013 Elsevier GmbH. All rights reserved.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban CD1a Dendritic cell Immunotherapy Matrix metalloproteinase Tissue inhibitor of matrix Metalloproteinase
Megjelenés:	Immunobiology. - 218 : 11 (2013), p. 1361-1369. -
További szerzők:	Bacskai Ildikó (1985-) (immunológus) Gogolák Péter (1968-) (biológus, immunológus) Türk-Mázló Anett (1989-) (molekuláris biológus) Szatmári István (1971-) (biológus) Rajnavölgyi Éva (1950-) (immunológus)
Pályázati támogatás:	TÁMOP-4.2.2.A-11/1/KONV-2012-0023-"VÉD-ELEM" TÁMOP NK 101538 OTKA
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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