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1.

001-es BibID:BIBFORM095818
Első szerző:Bodnár Magdolna
Cím:Synthesis and study of crosslinked chitosan-n-poly(ethylene glycol) nanoparticles / Magdolna Bodnar, John F. Hartmann, Janos Borbely
Dátum:2006
ISSN:1525-7797
Megjegyzések:The present investigation describes the synthesis and characterization of novel biodegradable nanoparticles based on chitosan. Poly(ethylene glycol) dicarboxylic acid was used for intramolecular cross-linking of the chitosan linear chains. The condensation reaction of carboxylic groups and pendant amino groups of chitosan was performed by using water-soluble carbodiimide. The prepared nanosystems were stable in aqueous media. The structure of the products was determined by nuclear magnetic resonance (NMR) spectroscopy, and the particle size was identified by dynamic light scattering (DLS) and transmission electron microscopy (TEM) measurements. It was found that biodegradable cross-linked chitosan nanoparticles experienced considerable swelling because of the length and flexibility of the cross-linking agent. The aqueous solutions or dispersions of nanoparticles were stable and clear or mildly opalescent systems depending on the ratio of cross-linking and molecular weight of chitosan, findings consistent with values of transmittance above 75%. Particle size measured by TEM varied in the range of 4-24 nm. In the swollen state, the average size of the individual particles measured by DLS was in the range of 50-120 nm depending on the molecular weight of chitosan and the ratio of cross-linking.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Biomacromolecules. - 7 : 11 (2006), p. 3030-3036. -
További szerzők:Hartmann, John F. Borbély János (1950-) (vegyész)
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2.

001-es BibID:BIBFORM050131
Első szerző:Bodnár Magdolna
Cím:Nanoparticles Prepared by Self-assembly of Chitosan and Poly-γ-glutamic Acid / M. Bodnar, I. Hajdu, G. Filipcsei, L. Daroczi, J. F. Hartmann, J. Borbely
Dátum:2007
ISBN:9781420061833
Tárgyszavak:Természettudományok Kémiai tudományok könyvfejezet
Megjelenés:NSTI Nanotech : Technical Proceedings Vol. 2. / ed. NanoScience & Technology Inst. - p. 143-146. -
További szerzők:Hajdu István (1981-) (vegyész) Filipcsei Genovéva Daróczi Lajos (1965-) (fizikus) Hartmann, John F. Borbély János (1950-) (vegyész)
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3.

001-es BibID:BIBFORM050116
Első szerző:Bodnár Magdolna
Cím:Biopolymer-based nanosystem for ferric ion removal from water / Magdolna Bodnár, István Hajdu, Eszter Rőthi, Nóra Harmati, Zsuzsanna Csikós, John F. Hartmann, Csaba Balogh, Béla Kelemen, János Tamás, János Borbély
Dátum:2013
ISSN:1383-5866
Megjegyzések:The removal of ferric ions from aqueous solutions by a nanoparticle-enhanced ultrafiltration techniquewas investigated. Biodegradable poly-gamma-glutamic acid (c-PGA), a linear biopolymer, and itscross-linked nanoparticles were used to complex the metal ions by forming nanosized spherical particleswith more or less deformability. These polymer?metal ion particles were then removed by membraneseparation. Two ultrafiltration techniques were studied with the aim of developing a nanoparticleenhancedseparation process for the efficient removal of ferric ions from model solutions. The influenceof parameters such as the feed c-PGA and Fe3+ concentrations, their proportions and the extent of crosslinkingof c-PGA were studied. It was observed that c-PGA could bind and remove ferric ions to producewater with low Fe3+ concentration. These studies show that optimal nano-membrane separation technologycan be performed, depending on the environment and quality of treatable water by the combinationof the filtration parameters and type of membrane techniques shown here.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Poly-gamma-glutamic
acid
Ferric
ion
Removal Ultrafiltration
Micro-irrigation
Megjelenés:Separation and Purification Technology. - 112 (2013), p. 26-33. -
További szerzők:Hajdu István (1981-) (vegyész) Rőthi Eszter Harmati Nóra Csikós Zsuzsanna Hartmann, John F. Balogh Csaba Kelemen Béla Tamás János (1959-) (környezetgazdálkodási agrármérnök) Borbély János (1950-) (vegyész)
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4.

001-es BibID:BIBFORM008968
Első szerző:Bodnár Magdolna
Cím:Preparation and characterization of cross-linked hyaluronan nanoparticles / Magdolna Bodnár, Lajos Daróczi, Gyula Batta, József Bakó, John F. Hartmann, János Borbély
Dátum:2009
Megjegyzések:The present investigation describes the synthesis and characterization of novel biodegradable nanoparticles based on hyaluronic acid (HA). The diamine, 2,2·(ethylenedioxy) bis(ethylamine) was used for cross-linking of the HA linear chains. The condensation reaction of amino groups and pendant carboxyl groups of HA was performed in aqueous media at room temperature using water-soluble carbodiimide. The prepared nanosystems, aqueous solutions, or dispersions of nanoparticles were stable, transparent, or mildly opalescent systems depending on the ratio of cross-linking, findings consistent with values of transmittance above 77%. The structure of products was determined by nuclear magnetic resonance spectroscopy, and the particle size was identified by laser light scattering (DLS) and transmission electron microscopy (TEM) measurements. Particle size measured by TEM varied less than 130 nm; in the swollen state, the average size of the particles measured by DLS was in the range of 30-140 nm depending on the ratio of cross-linking and the molecular weight of HA. Formation of cross-linked nanoparticles results in a viscosity drop compared to the viscosity of the corresponding solution of the HA, and this trend becomes decreasingly appreciable as the molecular weight of HA decreases.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Molekulatudomány
Hyaluronic acid
Nanoparticles
Cross-linking
Megjelenés:Colloid and Polymer Science. - 287 : 8 (2009), p. 991-1000. -
További szerzők:Daróczi Lajos (1965-) (fizikus) Batta Gyula (1953-) (molekula-szerkezet kutató) Bakó József (1981-) (vegyész) Hartmann, John F. Borbély János (1950-) (vegyész)
Pályázati támogatás:TÁMOP-4.2.2-08/1-2008-0019
TÁMOP
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5.

001-es BibID:BIBFORM050117
Első szerző:Hajdu István (vegyész)
Cím:Nanoparticles prepared by self-assembly of Chitosan and poly-γ-glutamic acid / Istvan Hajdu, Magdolna Bodnár, Genovéva Filipcsei, John F. Hartmann, Lajos Daróczi, Miklós Zrínyi, János Borbély
Dátum:2007
ISSN:0303-402X
Megjegyzések:The present paper describes the preparation and characterization of novel biodegradable nanoparticles based on self-assembly of poly-gamma-glutamic acid (γ-PGA) and chitosan (CH). The nanosystems were stable in aqueous media at low pH conditions. Solubility of the systems was determined by turbidity measurements. Surface charge and mobility were measured electrophoretically. The particle size and the size distribution of the polyelectrolyte complexes were identified by dynamic light scattering and transmission electron microscopy (TEM). It was found that the size and size distribution of the nanosystems depends on the concentrations of γ-PGA and CH solutions and their ratio as well as on the pH of the mixture and the order of addition. The diameter of individual particles was in the range of 20-285 nm measured by TEM, and the average hydrodynamic diameters were between 150 and 330 nm. These biodegradable, self-assembling stable nanocomplexes might be useful for several biomedical applications.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
γ-PGA
Chitosan
Polyelectrolyte
Nanoparticles
Complexation
Self-assembly
Electrophoretic mobility
Megjelenés:Colloid and Polymer Science. - 286 : 3 (2007), p. 343-350. -
További szerzők:Bodnár Magdolna Filipcsei Genovéva Hartmann, John F. Daróczi Lajos (1965-) (fizikus) Zrínyi Miklós (kémikus) Borbély János (1950-) (vegyész)
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6.

001-es BibID:BIBFORM043092
Első szerző:Keczánné Üveges Andrea (vegyész)
Cím:Synthesis of Polymeric Nanoparticles by Cross-Linking Copolymerization / Üveges Andrea, Szalóki Melinda, Hartmann John F., Hegedűs Csaba, Borbély János
Dátum:2008
ISSN:0024-9297 1520-5835
Megjegyzések:Soluble cross-linked nanoparticles were prepared by free radical copolymerization of styrene (ST, M1) and ethylene glycol dimethacrylate (EGDM, M2) monomers in homogeneous solution. Spherical nanoparticles were obtained in the early stage of polymerization, and no gelation occurred up to 66% of yield. The isolated particles are decorated with pendant vinyl groups that are target for further polymerization. The molar feed ratio was ST/EGDM = 5/5, the monomer concentration 0.556 mol/dm3 and the initiator concentration 5 mol %. It was found that as the conversion increased, the ratio of pendant vinyl groups reached a maximum value; however, the size of nanoparticles continued to increase with the reaction time. The molecular weight distributions were monomodal at short reaction times (30 and 60 min), however, at longer reaction times (90, 120, and 180 min) these became multimodal. This was caused by intraparticle reactions (branching and cross-linking) and possibly also by interparticle reactions (coupling). The reactive vinyl groups were detected by nuclear magnetic resonance spectroscopy (NMR). The size of nanoparticles in swollen state was determined by dynamic laser light scattering (DLS) method and in dried form by scanning electron microscopy (SEM). Molecular weight and distributions were measured by gel permeation chromatography (GPC).
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Macromolecules. - 41 : 4 (2008), p. 1223-1228. -
További szerzők:Szalóki Melinda (1981-) (vegyész) Hartmann, John F. Hegedűs Csaba (1953-) (fogszakorvos) Borbély János (1950-) (vegyész)
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7.

001-es BibID:BIBFORM013452
Első szerző:Keczánné Üveges Andrea (vegyész)
Cím:Synthesis of Nanoparticles by Cross-linking Copolymerization / A. Uveges, J.F. Hartmann, J. Borbely
Dátum:2007
Megjegyzések:Free radical cross-linking copolymerization of styrene with large amounts of ethylene glycol dimethacrylate (monomer feed: ST/EGDM = 5/5) has been investigated in toluene as a homogeneous solution. The conversion, the ratio of pendant vinyl groups and the size of the nanoparticles in the pregel state were measured at various reaction times until the onset of macrogelation. It was found that the highest possible polymer yields were 65% at 0.556 mol/dm3 monomer concentration and nearly 100% at 0.278 mol/dm3 monomer concentration without gelation. The molecular weight distributions were monomodal at low conversions and multimodal at higher conversions. The multimodal molecular weight distributions were caused by branching reactions and crosslinking within the nanoparticles. The copolymers obtained were soluble in standard organic solvents such as toluene and chloroform. Transmission electron micrographs proved the formation of spherical particles (TEM).
ISBN:1420061836
Tárgyszavak:Természettudományok Kémiai tudományok előadáskivonat
reactive polymeric nanoparticles
cross-linking polymerization
Megjelenés:Technical proceedings of the 2007 NSTI Nanotechnology Conference and Trade Show : NSTI Nanotech 2007, Santa Clara, May 20 - 24. 2007. Vol. 2. - p. 172-175. -
További szerzők:Hartmann, John F. Borbély János (1950-) (vegyész)
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8.

001-es BibID:BIBFORM013449
Első szerző:Keczánné Üveges Andrea (vegyész)
Cím:Synthesis of crosslinked polymer nanoparticles suitable for the formation of nanolayer organic films / Andrea Uveges, John F. Hartmann, Lajos Daroczi, Janos Borbely
Dátum:2009
ISSN:0303-402X
Megjegyzések:Free radical crosslinking copolymerization of styrene and ethylene glycol dimethacrylate (nST/nEGDM in feed=5/5) has been investigated in toluene. Variation of the reaction conditions allows the formation of macromolecules with low molecular weight (21.6 kDa and 12 nm in diameter), perfectly soluble branched particles in the early stage of the polymerization. Elongation of the reaction time leads to the formation of soluble/swelling microgels with medium molecular weight (156 kDa and 41-120 nm) and, finally, swelling/particularly soluble colloidal polymer particles with very high molecular weight (3.6 MDa and 59?324 nm). Conversion, molecular weight [by gel permeation chromatography (GPC)], ratio of pendant vinyl groups [by nuclear magnetic resonance (NMR)], size of nanoparticles in swollen [by dynamic light scattering (DLS)] and dried state [by transmission electron microscopy (TEM)], morphology [by scanning electron microscopy (SEM)], and nanolayer film formation (by SEM) were measured. The role of reaction conditions in producing different polymer structures and morphologies was demonstrated.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Free radical polymerization
Nanoparticles
Nanolayer film formation
Megjelenés:Colloid and Polymer Science. - 287 : 4 (2009), p. 471-479. -
További szerzők:Hartmann, John F. Daróczi Lajos (1965-) (fizikus) Borbély János (1950-) (vegyész)
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9.

001-es BibID:BIBFORM049205
Első szerző:Keresztessy Zsolt
Cím:Self-assembling chitosan/poly-γ-glutamic acid nanoparticles for targeted drug delivery / Zsolt Keresztessy, Magdolna Bodnár, Elizabeth Ber, Istvan Hajdu, Min Zhang, John F. Hartmann, Tamara Minko, János Borbély
Dátum:2009
ISSN:0303-402X
Megjegyzések:For the purpose of targeted drug delivery,composite biodegradable nanoparticles were prepared fromchitosan and the poly-?-glutamic acid via an ionotropicgelation process. These stable self-assembled nanoparticleswere characterized by dynamic light scattering, transmissionelectron microscopy, and atomic force microscopy,which demonstrated that the nanosystem consists ofspherical particles with a smooth surface both in aqueousenvironment and in dried state. Toxicity measurementsshowed that the composition is nontoxic when tested eitheron cell cultures or in animal feeding experiments. Toevaluate the potential of the nanosystem for intracellulardrug delivery, the nanoparticles were fluorescently labeledand folic acid was attached as a cancer cell-specifictargeting moiety. The ability of the particles to beinternalized was tested using confocal microscopic imagingon cultured A2780/AD ovarian cancer cells, which overexpressfolate receptors. The quantitative data obtained bydigital processing of the intensity of green color of eachpixel in the pictures inside the cell boundaries and totalintensity of fluorescence inside the cells showed that"targeted" particles internalized into the cells significantlyfaster and the total accumulation of these particles wassubstantially higher in the cancer cells when compared with"nontargeted" particles, which may facilitate effective andspecific cytoplasmic delivery of anticancer agents loadedinto such nanoparticles.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
chitosan
PGA
nanoparticles
in vivo toxicity
Megjelenés:Colloid And Polymer Science. - 287 : 7 (2009), p. 759-765. -
További szerzők:Bodnár Magdolna Ber, Elizabeth Hajdu István (1981-) (vegyész) Zhang, Min Hartmann, John F. Minkó Tamara Borbély János (1950-) (vegyész)
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10.

001-es BibID:BIBFORM063015
Első szerző:Maroda Mónika
Cím:Preparation and investigation of a cross-linked hyaluronan nanoparticles system / Mónika Maroda, Magdolna Bodnár, Szilvia Berkó, József Bakó, Gábor Erős, Erzsébet Csányi, Piroska Szabó-Révész, John F. Hartmann, Lajos Kemény, János Borbély
Dátum:2011
ISSN:0144-8617
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Carbohydrate Polymers. - 83 : 3 (2011), p. 1322-1329. -
További szerzők:Bodnár Magdolna Berkó Szilvia Bakó József (1981-) (vegyész) Erős Gábor Csányi Erzsébet Szabó-Révész Piroska (1950-) (gyógyszerész) Hartmann, John F. Kemény Lajos Borbély János (1950-) (vegyész)
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11.

001-es BibID:BIBFORM043728
Első szerző:Szalóki Melinda (vegyész)
Cím:Preparation of reactive polymeric nanoparticles / Melinda Szaloki, Robert Scribanek, John F. Hartmann, Csaba Hegedus, Janos Borbely
Dátum:2006
Megjegyzések:Polyreactions of multivinyl monomers in emulsion droplets lead to formation of crosslinked macromolecules. In the emulsion polymerization the surfactant-mediated nanoparticles involves the monomers serving as nanoreactors. It prevents gelation while allowing the growth of particles the defined volume. In this study we describe the formation of reactive polymeric nanoparticles (RPNPs) for potential use as dental materials or as a component of industrial powder coatings. As dental filling materials, since the predominant portion of polymerization is performed in advance, limited volumetric shrinking is expected to be observed during the final in situ photopolymerization step. On the other hand no necessary or limited use of toxic monomers is required. The correlation of monomer feed, crosslinking density, particle size, reactivity and swelling behavior of RPNPs is described.
Tárgyszavak:Természettudományok Kémiai tudományok konferenciacikk
Polymeric nanoparticles
Megjelenés:Polymeric Materials : Science & Engineering. - 94 : 1 (2006), p. 783-784. -
További szerzők:Skribanek Róbert Hartmann, John F. Hegedűs Csaba (1953-) (fogszakorvos) Borbély János (1950-) (vegyész)
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12.

001-es BibID:BIBFORM043841
Első szerző:Szalóki Melinda (vegyész)
Cím:Preparation of Reactive Polymeric Nanoparticles (RPNPs) / Szaloki M., Daroczi L., Hartmann J. F., Hegedus C., Borbely J.
Dátum:2007
Megjegyzések:Synthesis of polymeric nanoparticles attracts a great effort to obtain particles with desired size, surface and functionalities. Crosslinking polymerization methods have received considerable interest relation to the development of preparation of microgels, crosslinked nanoparticles, their composites and to study the gelation reactions. Many application fields have related to bulk crosslinked systems, e.g., in restorative dentistry, paint and powder coatings. Crosslinked nanoparticles can be formed in homogeneous solutions or under heterogeneous medium in micellar or emulsion conditions. Formation of polymers in emulsion also has an environmental aspect to reduce the volatile organic compounds (VOC). Reactive polymeric nanoparticles (PRNPs) were synthesized in heterogeneous medium by free radical non-linear copolymerization of mono (M1) and trivinyl acrylic (M2) monomers.
Tárgyszavak:Természettudományok Kémiai tudományok előadáskivonat
RPNPs
Megjelenés:NSTI Nanotechnology Conference : technical proceedings, 2007 (4) / ed. Nano Science and Technology Institute. - 309-312. -
További szerzők:Daróczi Lajos (1965-) (fizikus) Hartmann, John F. Hegedűs Csaba (1953-) (fogszakorvos) Borbély János (1950-) (vegyész)
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