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001-es BibID:	BIBFORM030280
Első szerző:	Nánási Péter Pál (élettanász)
Cím:	Effects of methylene blue and ascorbate on transmembrane potential in frog skeletal muscle / Péter P. Nánási, Mátyás Dely
Dátum:	1995
ISSN:	0306-3623
Megjegyzések:	1. The effects of methylene blue (MB, 10(-4) M) and ascorbate (ASC, 10(-4) M) on the resting membrane potential of frog skeletal muscle fibers were studied in Cl--free medium at various external K+ concentrations. 2. Muscle fibers formed two distinct populations according to their resting potentials (hyperpolarized to - 104 mV or depolarized to -31 mV) after a 90 min period of K+ withdrawal. ASC increased the relative contribution of hyperpolarized fibers, while in the presence of MB, all fibers depolarized during the 90 min of K+ withdrawal. 3. In the presence of 2.5 mM KC, ASC had no significant effect on the resting potential, while MB moved half of the fibers into the depolarized pool. Elevation of [K+](0) to 10 mM caused repolarization of all previously depolarized fibers (to -63 mV) in spite of the continuous presence of MB. 4. Ionic currents were measured during a 60 mV depolarization step using the double sucrose-gap technique. MB significantly increased the peak inward current, while ASC had no effect. The steady-state outward current was not affected by MB or ASC. 5. The results suggest that ionic conductances may be under redox control in frog skeletal muscle.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban egyetemen (Magyarországon) készült közlemény
Megjelenés:	General Pharmacology. - 26 : 6 (1995), p. 1307-1311. -
További szerzők:	Dely Mátyás
Internet cím:	DOI elektronikus változat Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM030360
035-os BibID:	(Scopus)0025987844 (WoS)A1991GD12500006 (PMID)1950591
Első szerző:	Puppi, A.
Cím:	Influence of the redox-state potential of biophase on electrically stimulated skeletal muscles (myographic and voltage-clamp analysis) / A. Puppi, P. P. Nanasi, M. Dely
Dátum:	1991
ISSN:	0231-424X
Megjegyzések:	Redox modulation of cholinergic and adrenergic mechanisms of excitatory tissues have been analyzed rather satisfactorily until recently. The aim of the present work is to give some initial guiding information about the redox modulation of electrogenic excitatory processes in skeletal muscles. It was observed, that on increasing the tissue redox-state potential (E0'), the amplitudes of muscle contractions are higher by 18.5 per cent than controls, but decreasing E0', the amplitudes of muscle contractions are lower by 10.5 per cents than controls. It means, that muscle contractions elicited by electric stimulation are also under redox control. One of the mechanisms responsible for this phenomenon is that following increased E0' values both peak current (I(p)) and steady-state current (I(ss)) increases, but after decreased E0' values I(ss) decreases. The role of other site of actions and mechanisms, i.e. ion channels, active transport, excitation-contraction coupling, and Na+-Ca2+ exchange diffusion processes, are also discussed.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény hazai lapban folyóiratcikk egyetemen (Magyarországon) készült közlemény
Megjelenés:	Acta Physiologica Hungarica. - 77 : 1 (1991), p. 33-41. -
További szerzők:	Nánási Péter Pál (1956-) (élettanász) Dely Mátyás
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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