Összesen 4 találat.


001-es BibID:BIBFORM087745
035-os BibID:(scopus)85089079170 (wos)000560523600001
Első szerző:Nánási Péter Pál (élettanász)
Cím:Editorial : Perspectives of Antiarrhythmic Drug Therapy : Disappointing Past, Current Efforts, and Faint Hopes / Nánási Péter P., Esther Pueyo, László Virág
Tárgyszavak:Orvostudományok Elméleti orvostudományok szerkesztőségi anyag
antiarrhythmic agents
antiarrhythmic strategies
proarrhythmic mechanisms
ardiac ion currents
cardiac arrhythmias
Megjelenés:Frontiers in Pharmacology. - 11 (2020), p. 1116. -
További szerzők:Pueyo, Esther Virág László (élettanász Szeged)
Internet cím:Szerző által megadott URL
Intézményi repozitóriumban (DEA) tárolt változat


001-es BibID:BIBFORM065194
035-os BibID:(cikkazonosító)e0151461 (WOS)000372807800012 (Scopus)84962190476
Első szerző:Pueyo, Esther
Cím:Experimentally-Based Computational Investigation into Beat-To-Beat Variability in Ventricular Repolarization and Its Response to Ionic Current Inhibition / E. Pueyo, C. E. Dangerfield, O. J. Britton, L. Virág, K. Kistamás , N. Szentandrássy, N. Jost, A. Varró, P. P. Nánási, K. Burrage, B. Rodríguez
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Plos One. - 11 : 3 (2016), p. e0151461. -
További szerzők:Dangerfield, Ciara Ellen Britton, Oliver J. Virág László (élettanász Szeged) Kistamás Kornél (1986-) (biológus) Szentandrássy Norbert (1976-) (élettanász) Jost Norbert Varró András (1954-) (farmakológus, klinikai farmakológus) Nánási Péter Pál (1956-) (élettanász) Burrage, Kevin Rodríguez, Blanca
Pályázati támogatás:NK-104331
Internet cím:Szerző által megadott URL
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001-es BibID:BIBFORM030209
035-os BibID:WOS:000298445500004
Első szerző:Pueyo, Esther
Cím:A multiscale investigation of repolarization variability and its role in cardiac arrhythmogenesis / Esther Pueyo, Alberto Corrias, László Virág, Norbert Jost, Tamás Szél, András Varró, Norbert Szentandrássy, Péter P. Nánási, Kevin Burrage, Blanca Rodríguez
Megjegyzések:Enhanced temporal and spatial variability in cardiac repolarization has been related to increased arrhythmic risk both clinically and experimentally. Causes and modulators of variability in repolarization and their implications in arrhythmogenesis are however not well understood. At the ionic level, the slow component of the delayed rectifier potassium current (I(Ks)) is an important determinant of ventricular repolarization. In this study, a combination of experimental and computational multiscale studies is used to investigate the role of intrinsic and extrinsic noise in I(Ks) in modulating temporal and spatial variability in ventricular repolarization in human and guinea pig. Results show that under physiological conditions: i), stochastic fluctuations in I(Ks) gating properties (i.e., intrinsic noise) cause significant beat-to-beat variability in action potential duration (APD) in isolated cells, whereas cell-to-cell differences in channel numbers (i.e., extrinsic noise) also contribute to cell-to-cell APD differences; ii), in tissue, electrotonic interactions mask the effect of I(Ks) noise, resulting in a significant decrease in APD temporal and spatial variability compared to isolated cells. Pathological conditions resulting in gap junctional uncoupling or a decrease in repolarization reserve uncover the manifestation of I(Ks) noise at cellular and tissue level, resulting in enhanced ventricular variability and abnormalities in repolarization such as afterdepolarizations and alternans.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
action-potential duration
short-term variability
guinea-pig ventricle
early afterdepolarizations
current fluctuations
egyetemen (Magyarországon) készült közlemény
Megjelenés:Biophysical Journal. - 101 : 12 (2011), p. 2892-2902. -
További szerzők:Corrias, Alberto Virág László (élettanász Szeged) Jost Norbert Szél Tamás Varró András (1954-) (farmakológus, klinikai farmakológus) Szentandrássy Norbert (1976-) (élettanász) Nánási Péter Pál (1956-) (élettanász) Burrage, Kevin Rodríguez, Blanca
Internet cím:DOI
Intézményi repozitóriumban (DEA) tárolt változat


001-es BibID:BIBFORM083000
035-os BibID:(cikkazonosító)1547 (WoS)000508451400002 (Scopus)85078809657
Első szerző:Sampedro-Puente, David Adolfo
Cím:Time Course of Low-Frequency Oscillatory Behavior in Human Ventricular Repolarization Following Enhanced Sympathetic Activity and Relation to Arrhythmogenesis / David Adolfo Sampedro-Puente, Jesus Fernandez-Bes, Norbert Szentandrássy, Péter Nánási, Peter Taggart, Esther Pueyo
Megjegyzések:Background and Objectives: Recent studies in humans and dogs have shown that ventricular repolarization exhibits a low-frequency (LF) oscillatory pattern following enhanced sympathetic activity, which has been related to arrhythmic risk. The appearance of LF oscillations in ventricular repolarization is, however, not immediate, but it may take up to some minutes. This study seeks to characterize the time course of the action potential (AP) duration (APD) oscillatory behavior in response to sympathetic provocations, unveil its underlying mechanisms and establish a potential link to arrhythmogenesis under disease conditions. Materials and Methods: A representative set of human ventricular computational models coupling cellular electrophysiology, calcium dynamics, ?-adrenergic signaling, and mechanics was built. Sympathetic provocation was modeled via phasic changes in ?-adrenergic stimulation (?-AS) and mechanical stretch at Mayer wave frequencies within the 0.03?0.15 Hz band. Results: Our results show that there are large inter-individual differences in the time lapse for the development of LF oscillations in APD following sympathetic provocation, with some cells requiring just a few seconds and other cells needing more than 3 min. Whereas, the oscillatory response to phasic mechanical stretch is almost immediate, the response to ?-AS is much more prolonged, in line with experimentally reported evidences, thus being this component the one driving the slow development of APD oscillations following enhanced sympathetic activity. If ?-adrenoceptors are priorly stimulated, the time for APD oscillations to become apparent is remarkably reduced, with the oscillation time lapse being an exponential function of the pre-stimulation level. The major mechanism underlying the delay in APD oscillations appearance is related to the slow IKs phosphorylation kinetics, with its relevance being modulated by the IKs conductance of each individual cell. Cells presenting short oscillation time lapses are commonly associated with large APD oscillation magnitudes, which facilitate the occurrence of pro-arrhythmic events under disease conditions involving calcium overload and reduced repolarization reserve. Conclusions: The time course of LF oscillatory behavior of APD in response to increased sympathetic activity presents high inter-individual variability, which is associated with different expression and PKA phosphorylation kinetics of the IKs current. Short time lapses in the development of APD oscillations are associated with large oscillatory magnitudes and pro-arrhythmic risk under disease conditions.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
low-frequency oscillations
beta-adrenergic stimulation
cardiac cell models
ventricular repolarization
sympathetic activity
Megjelenés:Frontiers in Physiology. - 10 (2020), p. 1547. -
További szerzők:Fernandez-Bes, Jesus Szentandrássy Norbert (1976-) (élettanász) Nánási Péter Pál (1956-) (élettanász) Taggart, Peter Pueyo, Esther
Pályázati támogatás:GINOP-2.3.2.-15-2016-00040
Internet cím:Szerző által megadott URL
Intézményi repozitóriumban (DEA) tárolt változat
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