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001-es BibID:	BIBFORM074550
035-os BibID:	(WoS)000427631700003 (Scopus)85040654509 (PubMed)29344775
Első szerző:	Almássy János (élettanász, biológus, angol-magyar szakfordító)
Cím:	New saliva secretion model based on the expression of Na+-K+ pump and K+ channels in the apical membrane of parotid acinar cells / Almássy János, Siguenza Elias, Skaliczki Marianna, Matesz Klara, Sneyd James, Yule David I., Nánási Péter P.
Dátum:	2018
ISSN:	0031-6768
Megjegyzések:	The plasma membrane of parotid acinar cells is functionally divided into apical and basolateral regions. According to the current model, fluid secretion is driven by transepithelial ion gradient, which facilitates water movement by osmosis into the acinar lumen from the interstitium. The osmotic gradient is created by the apical Cl? efflux and the subsequent paracellular Na+ transport. In this model, the Na+-K+ pump is located exclusively in the basolateral membrane and has essential role in salivary secretion, since the driving force for Cl? transport via basolateral Na+?K+?2Cl? cotransport is generated by the Na+-K+ pump. In addition, the continuous electrochemical gradient for Cl? flow during acinar cell stimulation is maintained by the basolateral K+ efflux. However, using a combination of single-cell electrophysiology and Ca2+-imaging, we demonstrate that photolysis of Ca2+ close to the apical membrane of parotid acinar cells triggered significant K+ current, indicating that a substantial amount of K+ is secreted into the lumen during stimulation. Nevertheless, the K+ content of the primary saliva is relatively low, suggesting that K+ might be reabsorbed through the apical membrane. Therefore, we investigated the localization of Na+-K+ pumps in acinar cells. We show that the pumps appear evenly distributed throughout the whole plasma membrane, including the apical pole of the cell. Based on these results, a new mathematical model of salivary fluid secretion is presented, where the pump reabsorbs K+ from and secretes Na+ to the lumen, which can partially supplement the paracellular Na+ pathway.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Parotid acinar cell Saliva production Fluid secretion model Na+-K+ pump BK channel maxiK Gardos channel
Megjelenés:	Pflugers Archiv-European Journal Of Physiology. - 470 : 4 (2018), p. 613-621. -
További szerzők:	Siguenza, Elias Skaliczki Marianna Matesz Klára (1949-) (anatómus, neurobiológus) Sneyd, James Yule, David I. Nánási Péter Pál (1956-) (élettanász)
Pályázati támogatás:	GINOP-2.3.2-15-2016-00040 GINOP EFOP-3.6.2-16-2017-00006 EFOP
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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