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1.

001-es BibID:BIBFORM055859
Első szerző:Beck Zoltán (molekuláris biológus, mikrobiológus)
Cím:Interactions between HTLV type I and HIV type 1 in monocyte-derived macrophages cultured in vitro / Beck Zoltán, Szabó Judit, Liu Xiangdong, Bácsi Attila, Ebbesen Peter, D. Tóth Ferenc
Dátum:2001
Tárgyszavak:Természettudományok Biológiai tudományok idézhető absztrakt
Megjelenés:AIDS Research And Human Retroviruses. - 17 : Suppl. 1 (2001), p. 51. -
További szerzők:Szabó Judit (1963-) (szakorvos, klinikai mikrobiológus) Liu, Xiangdong Bácsi Attila (1967-) (immunológus) Ebbesen, Peter Tóth Ferenc, D. (1940-2004) (mikrobiológus, élettanász)
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2.

001-es BibID:BIBFORM019703
Első szerző:Prohászka Zoltán
Cím:Two parallel routes of the complement-mediated antibody-dependent enhancement of HIV-1 infection / Prohászka Z., Nemes J., Hidvégi T., D. Tóth F., Kerekes K., Erdei A., Szabó J., Ujhelyi E., Thielens N., Dierich M. P., Spath P., Ghebrehiwet B., Hampl H., Kiss J., Arlaud G., Füst G.
Dátum:1997
ISSN:0269-9370
Megjegyzések:To study the mechanism of the complement-mediated antibody-dependent enhancement (C'-ADE) of HIV infection which may play a significant role in the progression of HIV-disease. METHODS: In vitro complement activating and complement-mediated HIV-infection enhancing abilities of three human anti-gp41 monoclonal antibodies (MAb) were tested. C'-ADE was estimated using HIV-1IIIB and CR2 (CD21)-carrying MT-4 target cells. Normal human serum (NHS), purified C1q, C1q-deficient (C1qD) and C2-deficient (C2D) human sera were applied as complement sources. RESULTS: All MAb mediated increased C1q binding to solid-phase gp41. All MAb had a marked dose-dependent and strictly complement-mediated HIV-infection enhancing effect. Mixtures of the MAb with purified C1q also significantly increased HIV-1 infection. C1qD serum had a markedly lower enhancing effect than NHS, which could be raised to normal level by addition of purified C1q. Pretreatment of the target cells with anti-CR2 antibodies only partially inhibited the enhancing effect of the MAb plus normal human serum. CONCLUSION: These novel findings indicate that besides the well-known facilitation of entry of HIV-1 by the interaction between virus-bound C3 fragments and CR2 present on the target cells, fixation of C1q to intact virions also results in an enhanced productive HIV-1 infection in the MT-4 cell cultures.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Aids. - 11 : 8 (1997), p. 949-958. -
További szerzők:Nemes József Hidvégi Tünde Tóth Ferenc, D. (1940-2004) (mikrobiológus, élettanász) Kerekes Krisztina Erdei Anna Szabó Judit (1963-) (szakorvos, klinikai mikrobiológus) Ujhelyi Eszter Thielens, Nicole Dierich, Manfred P. Spath Peter Ghebrehiwet, Berhane Hampl, Hartmut Kiss Jolán Arlaud, Gerard Füst György (Budapest)
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3.

001-es BibID:BIBFORM045393
Első szerző:Szabó Judit (szakorvos, klinikai mikrobiológus)
Cím:Strong correlation between the complemet-mediated antibody-dependent enhancement of HIV-1 infection and plasma viral load / Szabó J., Prohászka Z., D. Tóth F., Gyuris Á., Segesdi J., Bánhegyi D., Ujhelyi E., Minárovits J., Füst G.
Dátum:1999
ISSN:0269-9370
Megjegyzések:We have previously demonstrated that complement-mediated antibody-dependent enhancement (C-ADE) of HIV-1 infection correlates with accelerated immunosuppression and disease progression in HIV-1-infected individuals. In the present work the relationship between C-ADE and plasma HIV-1 RNA concentrations was studied to determine the effect of C-ADE on viral replication. METHODS: Three studies were performed: (a) C-ADE and HIV-1 RNA concentrations were determined in the serum and plasma aliquots taken at the same time from 98 HIV patients, mostly in the advanced stage of the disease; (b) the above two parameters as well as HIV enzyme-linked immunosorbent assay (ELISA)-reactive antibodies (Abbott HIV 1/2 test), and p24 antigen levels (Abbott antigen test; Abbott, Delkenheim, Germany) were determined in four seroconversion panels purchased from the Boston Biomedica firm; (c) changes of HIV-1 RNA concentration and C-ADE during a 17 month follow-up period were determined in 18 HIV-infected patients. C-ADE was measured by the method previously established in our laboratories. The results were expressed by an enhancement/neutralization index (E/NI). HIV-1 RNA levels were determined with the Amplicor monitor kit (Roche, Basel, Switzerland), and in some experiments with the nucleic acid sequence based amplification (Organon Teknika, Turnhout, Belgium) kits. RESULTS: (a) We found a highly significant (P<0.0001) positive correlation between E/NI values reflecting the extent of HIV-1 infection enhancement and plasma HIV-1 RNA levels. Both E/NI and HIV-1 RNA levels negatively correlated to the CD4 cell counts. (b) C-ADE was first detected just before, or concomitantly with, seroconversion in 4/4 seroconversion panels. (c) Both E/NI values and HIV-1 RNA levels significantly (P<0.001) increased during a 17 month observation period in 18 HIV-infected patients. CONCLUSION: We found strong association between the extent of the complement-mediated antibody-dependent enhancement of HIV-1 infection and the plasma viral load in HIV patients. On the basis of these findings, C-ADE correlates with HIV replication in vivo, and potentially contributes to the progression of HIV disease.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Aids. - 13 : 4 (1999), p. 1841-1849. -
További szerzők:Prohászka Zoltán Tóth Ferenc, D. (1940-2004) (mikrobiológus, élettanász) Gyuris Á. Segesdi J. Bánhegyi Dénes Ujhelyi Eszter Minárovits János Füst György (Budapest)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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4.

001-es BibID:BIBFORM019698
Első szerző:Szabó Judit (szakorvos, klinikai mikrobiológus)
Cím:Reciprocal interactions between human cytomegalovirus and human T cell leukemia-lymphoma virus type I in monocyte-derived macrophages cultured in vitro / Szabó J., Bácsi A., Andirkó I., Kiss J., Nemes J., D. Tóth F.
Dátum:1998
ISSN:0889-2229
Megjegyzések:Infection of macrophages with human cytomegalovirus (HCMV) has been shown to be nonlytic and exclusively cell associated. Human T cell leukemia-lymphoma virus type I (HTLV-I) is capable of establishing productive infection in macrophages. We studied the interactions between HCMV and HTLV-I in monocyte-derived macrophages cultured in vitro. We found that coinfection of macrophages with HCMV and HTLV-I significantly enhanced HCMV replication, resulting in release of infectious HCMV from dually infected cells. On the other hand, HCMV inhibited HTLV-I replication in macrophages coinfected with both viruses. Reciprocal interactions between HCMV and HTLV-I were mediated by their trans-acting proteins. Results of transfection studies demonstrated that the tax gene product of HTLV-I alone was capable of upregulating HCMV production. In a transient gene expression assay the immediate-early 2 (IE2) protein of HCMV alone could inhibit HTLV-I replication, whereas the IE1 protein, which had no effect by itself, produced a synergistic inhibitory effect together with the IE2 protein. Results from this study suggest that in vivo double infection of macrophages with HCMV and HTLV-I may contribute to the dissemination of HCMV infection in patients suffering from HTLV-I-associated T cell leukemia-lymphoma.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Aids Research and Human Retroviruses. - 14 : 8 (1998), p. 699-709. -
További szerzők:Bácsi Attila (1967-) (immunológus) Andirkó István Kiss J. Nemes J. Tóth Ferenc, D. (1940-2004) (mikrobiológus, élettanász)
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5.

001-es BibID:BIBFORM019688
Első szerző:Szabó Judit (szakorvos, klinikai mikrobiológus)
Cím:Differential patterns of interaction between HIV type 1 and HTLV type I in monocyte-derived macrophages cultured in vitro : implications for in vivo coinfection with HIV type 1 and HTLV type I / Szabó J., Beck Z., Csomán É., Liu X., Andirkó I., Kiss J., Bácsi A., Ebbesen P., D. Tóth F.
Dátum:1999
ISSN:0889-2229
Megjegyzések:The interaction between human immunodeficiency virus type 1 (HIV-1) and human T cell leukemia-lymphoma virus type I (HTLV-I) has generated substantial interest. However, there is disagreement on the in vivo consequences of the double infection. We investigated the interactions between HIV-1 and HTLV-I in monocyte-derived macrophages cultured in vitro . For study, the T cell-tropic strain IIIB and the macrophagetropic strain Ada-M of HIV-1 were used. The HTLV-I was prepared from the supernatants of the virus-producing MT-2 cell line. We found that coinfection of macrophages with T cell-tropic HIV-1 and HTLV-I significantly enhanced HIV-1 replication, whereas double infection of the cells with macrophage-tropic HIV-1 and HTLV-I resulted in marked upregulation of HTLV-I production. Stimulatory interactions between HIV1 and HTLV-I were mediated by their trans -acting proteins. Results of study on nuclear translocation of proviral DNA showed that the tax gene product of HTLV-I was able to facilitate the nuclear import of the reversetranscribed HIV-1IIIB DNA. In contrast, the HIV-1 Tat protein did not increase the intranuclear trafficking of HTLV-I DNA, which suggests another mechanism for HTLV-I enhancement by the tat gene product. In conclusion, this study provides possible mechanisms whereby coinfection of an individual with HIV-1 and HTLV-I may influence the clinical outcome of double infection.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Aids Research And Human Retroviruses. - 15 : 18 (1999), p. 1653-1666. -
További szerzők:Beck Zoltán (1970-) (molekuláris biológus, mikrobiológus) Csomán Éva Liu, Xiangdong Andirkó István Kiss Jolán Bácsi Attila (1967-) (immunológus) Ebbesen, Peter Tóth Ferenc, D. (1940-2004) (mikrobiológus, élettanász)
Borító:

6.

001-es BibID:BIBFORM019702
Első szerző:Tóth Ferenc, D. (mikrobiológus, élettanász)
Cím:Bidirectional enhancing activities between human cell leukemia-lymphoma virus type I and human cytomegalovirus in human term syncytiotrophoblast cells cultured in vitro / D. Tóth F., Aboagye-Mathiesen G., Szabó J., Liu X., Mosborg-Petersen P., Kiss J., Hager H., Zdravkovic M., Andirkó I., Aranyosi J., Ebbesen P.
Dátum:1995
ISSN:0889-2229
Megjegyzések:The syncytiotrophoblast layer of the human placenta has an important role in limiting transplacental viral spread from mother to fetus. Human cytomegalovirus (HCMV) is capable of establishing a latent infection in syncytiotrophoblast cells, with restriction of gene expression to immediate-early and early proteins. We analyzed the extent of replication of human T cell leukemia-lymphoma virus type I (HTLV-I) in human term syncytiotrophoblasts infected with HTLV-I alone or coinfected with HTLV-I and HCMV. Although syncytiotrophoblasts could be infected with cell-free HTLV-I, no viral protein expression was found in the singly infected cells. On the contrary, coinfection of the cells with HTLV-I and HCMV resulted in simultaneous replication of both viruses. Bidirectional enhancing activities between HTLV-I and HCMV were mediated primarily by the Tax and immediate-early proteins, respectively. The stimulatory effect of HTLV-I Tax on HCMV replication appeared to be mediated partly by tumor necrosis factor beta and transforming growth factor beta-1. We observed formation of pseudotypes with HTLV-I nucleocapsids within HCMV envelopes, whereas HCMV was not pseudotyped by HTLV-I envelopes in dually infected syncytiotrophoblast cells. Our data suggest that in vivo dual infection of syncytiotrophoblast cells with HTLV-I and HCMV may facilitate the transplacental transmission of both viruses.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
külföldön készült közlemény
Megjelenés:Aids Research And Human Retroviruses. - 11 : 12 (1995), p. 1495-1507. -
További szerzők:Aboagye-Mathiesen, George Szabó Judit (1963-) (szakorvos, klinikai mikrobiológus) Liu, Xiangdong Mosborg-Petersen, P. Kiss Jolán Hager Henrik Zdravkovic, Milan Andirkó István Aranyosi János (1963-) (szülész-nőgyógyász) ifj. Ebbesen, Peter
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