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001-es BibID:	BIBFORM019692
Első szerző:	Bácsi Attila (immunológus)
Cím:	Placental macrophage contact potentiates the complete replicative cycle of human cytomegalovirus in syncytiotrophoblast cells : role of interleukin-8 and transforming growth factor-beta 1 / Bácsi A., Aranyosi J., Beck Z., Ebbesen P., Andirkó I., Szabó J., Lampé L., Kiss J., Gergely L., D. Tóth F.
Dátum:	1999
ISSN:	1079-9907
Megjegyzések:	Although syncytiotrophoblast (ST) cells can be infected by human cytomegalovirus (HCMV), in vitro studies have indicated that ST cells do not support the complete viral reproductive cycle, or HCMV replication may occur in less than 3% of ST cells. The present study tested the possibility that placental macrophages might enhance activation of HCMV carried in ST cells and, further, that infected ST cells would be capable of transmitting virus to neighboring macrophages. For this purpose, we studied HCMV replication in ST cells grown alone or cocultured with uninfected placental macrophages. Our results demonstrated that HCMV gene expression in ST cells was markedly upregulated by coculture with macrophages, resulting in release of substantial amounts of infectious virus from HCMV-infected ST cells. After having become permissive for viral replication, ST cells delivered HCMV to the cocultured macrophages, as evidenced by detection of virus-specific antigens in these cells. The stimulatory effect of coculture on HCMV gene expression in ST cells was mediated by marked interleukin-8 (IL-8) and transforming growth factor-beta1 (TGF-beta1) release from macrophages, an effect caused by contact between the different placental cells. Our findings indicate an interactive role for the ST layer and placental macrophages in the dissemination of HCMV among placental tissue. Eventually, these interactions may contribute to the transmission of HCMV from mother to the fetus.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban egyetemen (Magyarországon) készült közlemény
Megjelenés:	Journal Of Interferon And Cytokine Research. - 19 : 10 (1999), p. 1153-1160. -
További szerzők:	Aranyosi János (1963-) (szülész-nőgyógyász) ifj. Beck Zoltán (1970-) (molekuláris biológus, mikrobiológus) Ebbesen, Peter Andirkó István Szabó Judit (1963-) (szakorvos, klinikai mikrobiológus) Lampé László (1929-2021) (szülész-nőgyógyász) Kiss Jolán Gergely Lajos (1940-) (szakorvos, klinikai mikrobiológus) Tóth Ferenc, D. (1940-2004) (mikrobiológus, élettanász)
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001-es BibID:	BIBFORM019705
Első szerző:	Nagy Endre V. (belgyógyász, endokrinológus)
Cím:	Sera but not immunoglobulins of ophthalmic Graves' patients stimulate human embryonal fibroblasts' biosynthetic activity in culture / V. Nagy E., Kálmán K., Szabó J., Bakó Gy., Gergely L., Leövey A.
Dátum:	1991
ISSN:	0171-2985
Megjegyzések:	The retroocular connective tissue changes in the ophthalmopathy of Graves' disease are known, however, the mechanism which leads to the increase in fibroblast number and activity is poorly understood. Using human embryonal fibroblast monolayers, fibroblast biosynthetic activity in the presence of sera, immunoglobulin deprived sera or immunoglobulins of Graves' patients with and without ophthalmopathy has been measured. Both sera and immunoglobulin deprived sera of the ophthalmic Graves' patients caused a marked increase of protein synthesis and a moderate increase of the sulphated glycosaminoglycan synthesis of fibroblasts. The same stimulatory effect was not found when immunoglobulin in fetal calf serum was used instead of sera, though anti-fibroblast IgG-s were present both in the sera and separated immunoglobulin fractions, as it has been demonstrated in an ELISA system. We conclude that the sera of ophthalmic Graves' patients contains a factor which stimulates human embryonal fibroblasts' biosynthetic activity in culture; this factor is not an immunoglobulin. The system described here seems to be suitable for studying the accompanying connective tissue changes in Graves' disease.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban egyetemen (Magyarországon) készült közlemény
Megjelenés:	Immunobiology. - 182 : 5 (1991), p. 405-413. -
További szerzők:	Kálmán K. Szabó Judit (1963-) (szakorvos, klinikai mikrobiológus) Bakó Gyula (1951-) (belgyógyász) Gergely Lajos (1940-) (szakorvos, klinikai mikrobiológus) Leövey András (1926-) (belgyógyász)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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